Development Level

Tbio 19 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

decreased mean corpuscular vol... 2 | 79
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal vertebrae morphology 1 | 18
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46

Disease

Carcinoma 18 | 11,493
ovarian cancer 17 | 8,520
Breast cancer 16 | 3,578
Cancer 14 | 2,499
glioblastoma 14 | 5,792
psoriasis 14 | 6,694
adult high grade glioma 12 | 3,801
lung cancer 12 | 4,740
medulloblastoma, large-cell 12 | 6,241
interstitial cystitis 11 | 2,312
Astrocytoma, Pilocytic 10 | 3,081
atypical teratoid / rhabdoid tumor 10 | 5,112
group 3 medulloblastoma 9 | 4,104
osteosarcoma 9 | 7,950
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
lung adenocarcinoma 8 | 2,716
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
Alzheimer's disease 6 | 658
Kidney cancer 6 | 2,613
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
group 4 medulloblastoma 6 | 1,855
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
Carcinoma, Pancreatic Ductal 5 | 20
Rheumatoid arthritis 5 | 1,191
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primitive neuroectodermal tumor 5 | 3,035
Strabismus 4 | 270
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Adenoid Cystic Carcinoma 3 | 99
Atopic dermatitis 3 | 952
Blepharoptosis 3 | 231
Brachydactyly 3 | 156
Carcinoma, Adenoid Cystic 3 | 99
Carcinoma, Squamous Cell 3 | 110
Cataract 3 | 297
Cerebrovascular disease 3 | 238
Crohn's disease 3 | 321
Esophageal Squamous Cell Carcinoma 3 | 77
Failure to gain weight 3 | 365
Glaucoma 3 | 239
Heart disease 3 | 306
Lens Opacities 3 | 231
Liver cancer 3 | 604
Lung Neoplasms 3 | 232
Lymphoid leukemia 3 | 160
Muscle hypotonia 3 | 571
Pediatric failure to thrive 3 | 365
Short stature 3 | 531
Squamous cell carcinoma of esophagus 3 | 77
adrenocortical carcinoma 3 | 1,428
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
spina bifida 3 | 1,074
Acquired scoliosis 2 | 281
Byzanthine arch palate 2 | 194
Colonic Neoplasms 2 | 142
Curvature of spine 2 | 282
Delayed bone age 2 | 136
Dementia 2 | 175
Diarrhea 2 | 253
Down syndrome 2 | 499
Electroencephalogram abnormal 2 | 101
Epilepsy 2 | 792
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hypertension 2 | 396
Liver Cirrhosis 2 | 181
Motor delay 2 | 147
Multiple Sclerosis 2 | 540
Neurodegenerative disease 2 | 414
No development of motor milestones 2 | 147
Pectus excavatum 2 | 100
Peripheral vascular disease 2 | 87
Phenotypic variability 2 | 150
Seizures 2 | 596
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
nasopharyngeal carcinoma 2 | 1,058
posterior fossa group A ependymoma 2 | 468
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 24 | 16,909
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 12 | 12,091
Transcription Factor 9 | 1,400
Epigenetic 3 | 242

Reactome Pathway

NOTCH3 Intracellular Domain Re... 24 | 24
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Mastermind-like domain-containing protein 1 MAMLD1 Tbio Non-IDG -1.97732 91.2 52
Plexin-D1 PLXND1 Tbio Non-IDG -1.64721 46.3 171
Protein KIBRA WWC1 Tbio Non-IDG -1.96854 92.8 130
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Fatty acid-binding protein, brain FABP7 Tbio Non-IDG -2.16587 158.5 416
Disks large-associated protein 5 DLGAP5 Tbio Non-IDG -1.61614 44.1 180
Histone acetyltransferase KAT2A KAT2A Tbio Epigenetic -2.46487 271.9 262
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
DNA-binding protein Ikaros IKZF1 Tbio Transcription Factor -2.66732 483.6 400