Development Level

Tbio 7 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

abnormal behavior 1 | 298
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 8 | 11,493
psoriasis 8 | 6,694
medulloblastoma, large-cell 7 | 6,241
ovarian cancer 7 | 8,520
lung cancer 6 | 4,740
osteosarcoma 6 | 7,950
Cancer 5 | 2,499
group 3 medulloblastoma 5 | 4,104
tuberculosis 5 | 2,010
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
Mammary Neoplasms 4 | 425
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
Failure to gain weight 3 | 365
Kidney cancer 3 | 2,613
Pediatric failure to thrive 3 | 365
Penile hypospadias 3 | 106
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
ependymoma 3 | 4,679
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
Acquired scoliosis 2 | 281
Adenoid Cystic Carcinoma 2 | 99
Alagille syndrome 2 | 15
Angle class 2 malocclusion 2 | 57
Angle class 3 malocclusion 2 | 57
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Atrial Septal Defects 2 | 85
Autistic Disorder 2 | 364
Brachydactyly 2 | 156
Bushy eyebrows 2 | 49
Byzanthine arch palate 2 | 194
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Squamous Cell 2 | 110
Cataract 2 | 297
Congenital Epicanthus 2 | 177
Congenital deafness 2 | 185
Congenital dislocation of radial head 2 | 14
Crohn's disease 2 | 321
Cryptorchidism 2 | 296
Curvature of spine 2 | 282
Deafness 2 | 198
Down syndrome 2 | 499
Downward slant of palpebral fissure 2 | 158
Encephalitis 2 | 64
Esophageal Squamous Cell Carcinoma 2 | 77
Hearing Loss, Partial 2 | 185
Hirsutism 2 | 47
Hydrocephalus 2 | 152
Hypoplastic mandible condyle 2 | 275
Immune system cancer 2 | 140
Joint laxity 2 | 54
Lens Opacities 2 | 231
Liver cancer 2 | 604
Long eyelashes 2 | 37
Low set ears 2 | 181
Lung Neoplasms 2 | 232
Lymphoid leukemia 2 | 160
Malocclusion 2 | 57
Mandibular hypoplasia 2 | 275
Melanoma 2 | 711
Micrognathism 2 | 275
Microstomia 2 | 78
Neuroectodermal Tumor, Primitive 2 | 8
Neuroectodermal Tumors, Primitive 2 | 8
Patent ductus arteriosus 2 | 90
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Short distal phalanges 2 | 50
Short stature 2 | 531
Small head 2 | 374
Squamous cell carcinoma of esophagus 2 | 77
Strabismus 2 | 270
Uterine Cervical Neoplasm 2 | 25
Uterine Cervical Neoplasms 2 | 26
aldosterone-producing adenoma 2 | 665
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
hearing impairment 2 | 199
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
ulcerative colitis 2 | 1,819
urothelial carcinoma 2 | 318
Bowed and upward slanting eyebrows 1 | 41
Extra cusp on inside of front tooth 1 | 3
Short metatarsal 1 | 21
Thick, flared eyebrows 1 | 41

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Non-IDG 6 | 12,091
Transcription Factor 3 | 1,400
Enzyme 1 | 4,145
Epigenetic 1 | 242

Reactome Pathway

NOTCH2 intracellular domain re... 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mastermind-like domain-containing protein 1 MAMLD1 Tbio Non-IDG -1.97732 91.2 52
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Granzyme B GZMB Tchem Enzyme -3.33029 2026.7 762
Low affinity immunoglobulin epsilon Fc receptor FCER2 Tchem Non-IDG -2.51671 325.7 1205
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.82854 72.4 136
Mastermind-like protein 1 MAML1 Tbio Non-IDG -1.65962 41.3 189
Recombining binding protein suppressor of hairless RBPJ Tbio Transcription Factor -2.67790 444.5 266
Neurogenic locus notch homolog protein 2 NOTCH2 Tchem Non-IDG -2.52434 287.2 451