Development Level

Tchem 17 | 1,598
Tbio 12 | 11,445
Tclin 1 | 613

IMPC Phenotype

abnormal behavior 2 | 298
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal lens morphology 1 | 81
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 23 | 11,493
Cancer 17 | 2,499
glioblastoma 17 | 5,792
osteosarcoma 17 | 7,950
psoriasis 17 | 6,694
ovarian cancer 16 | 8,520
lung cancer 13 | 4,740
atypical teratoid / rhabdoid tumor 11 | 5,112
medulloblastoma, large-cell 11 | 6,241
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
malignant mesothelioma 9 | 3,232
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Crohn's disease 6 | 321
juvenile dermatomyositis 6 | 1,187
Arthritis 5 | 290
Kidney cancer 5 | 2,613
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
posterior fossa group A ependymoma 5 | 468
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Bipolar Disorder 4 | 666
Breast cancer 4 | 3,578
Rheumatoid arthritis 4 | 1,191
Vascular disease 4 | 319
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
esophageal adenocarcinoma 4 | 737
group 3 medulloblastoma 4 | 4,104
hepatocellular carcinoma 4 | 547
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
medulloblastoma 4 | 720
pancreatic cancer 4 | 2,398
primary Sjogren syndrome 4 | 735
spina bifida 4 | 1,074
Alzheimer's disease 3 | 658
Arthritis, Rheumatoid 3 | 174
Autosomal recessive predisposition 3 | 1,442
Blau syndrome 3 | 9
Colitis, Ulcerative 3 | 59
Edema 3 | 81
Hypohidrotic ectodermal dysplasia 3 | 15
Inflammatory bowel disease 3 | 151
Leprosy 3 | 73
Liver Cirrhosis, Experimental 3 | 769
Lung Neoplasms 3 | 232
Multiple Sclerosis 3 | 540
Myocardial Reperfusion Injury 3 | 37
Pick disease 3 | 1,894
Short stature 3 | 531
Waldenstrons macroglobulinemia 3 | 765
X-linked lymphoproliferative syndrome 2 3 | 4
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
dermatomyositis 3 | 966
gastric cancer 3 | 459
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
pituitary cancer 3 | 1,972
sarcoidosis 3 | 370
Acquired scoliosis 2 | 281
Atopic dermatitis 2 | 952
Attention deficit hyperactivity disorder 2 | 278
Carcinoma, Hepatocellular 2 | 228
Cholestasis 2 | 155
Coronary artery disease 2 | 268
Curvature of spine 2 | 282
Dermatitis 2 | 157
Failure to gain weight 2 | 365
Flexion contracture of proximal interphalangeal joint 2 | 75
Hypersensitivity reaction type II disease 2 | 253
Inflammatory bowel disease 1 2 | 5
Liver carcinoma 2 | 240
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Retinal Detachment 2 | 51
Status Epilepticus 2 | 98
Toxic encephalopathy 2 | 141
Type 2 diabetes mellitus 2 | 272
active Crohn's disease 2 | 922
astrocytoma 2 | 1,146
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
pancreatic carcinoma 2 | 562
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Kinase 13 | 634
Enzyme 10 | 4,145
Non-IDG 7 | 12,091

Reactome Pathway

NOD1/2 Signaling Pathway 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Caspase-4 CASP4 Tchem Enzyme -2.19377 147.3 520
Nucleotide-binding oligomerization domain-containing protein 1 NOD1 Tchem Non-IDG -2.47114 318.1 318
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.94112 884.9 183
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.90517 75.2 151
Ubiquitin-conjugating enzyme E2 N UBE2N Tbio Non-IDG -2.08846 107.8 268
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378