Development Level

Tbio 34 | 10,625
Tchem 17 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 633
decreased lean body mass 2 | 195
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased bone mineral content 1 | 157
embryonic lethality prior to o... 1 | 148
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 39 | 8,491
Multiple myeloma 29 | 1,327
lung cancer 25 | 4,473
psoriasis 24 | 6,685
osteosarcoma 21 | 7,933
glioblastoma 19 | 5,572
HIV Infections 14 | 99
Cancer 13 | 2,346
dermatomyositis 12 | 966
Waldenstrons macroglobulinemia 9 | 764
malignant mesothelioma 9 | 3,163
medulloblastoma, large-cell 9 | 6,234
Breast cancer 8 | 3,098
atypical teratoid / rhabdoid tumor 8 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
astrocytoma 7 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
Mantle cell lymphoma 6 | 20
non-small cell lung cancer 6 | 2,798
oligodendroglioma 6 | 2,849
Pick disease 5 | 1,893
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
non primary Sjogren syndrome sicca 5 | 840
pediatric high grade glioma 5 | 2,712
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 1,563
astrocytic glioma 4 | 2,241
ependymoma 4 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
pancreatic cancer 4 | 2,300
pilocytic astrocytoma 4 | 3,086
primary pancreatic ductal adenocarcinoma 4 | 1,271
IGA Glomerulonephritis 3 | 454
acute myeloid leukemia 3 | 785
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
interstitial cystitis 3 | 2,299
lung adenocarcinoma 3 | 2,714
medulloblastoma 3 | 1,524
posterior fossa group A ependymoma 3 | 1,511
primary Sjogren syndrome 3 | 788
progressive supranuclear palsy 3 | 674
ulcerative colitis 3 | 2,087
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Heat Stroke 2 | 12
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Osteoporosis 2 | 259
Parkinson's disease 2 | 364
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Squamous cell carcinoma of esophagus 2 | 82
Stevens-Johnson syndrome 2 | 91
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
chronic kidney disease 2 | 90
cutaneous lupus erythematosus 2 | 1,056
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Amyotrophic Lateral Sclerosis 1 | 432
Anemia 1 | 252
Animal Mammary Neoplasms 1 | 135
Ankylosing spondylitis 1 | 138
Barrett's esophagus 1 | 185
Bladder Neoplasm 1 | 109
COPD 1 | 116
Carpal tunnel syndrome 1 | 19
Cleft palate 1 | 125
Cockayne syndrome 1 | 54
Common variable immunodeficiency 1 | 98
Contact Dermatitis 1 | 80
Crohn Disease 1 | 97
Degenerative polyarthritis 1 | 93
Diabetes Mellitus, Non-Insulin-Dependent 1 | 161
Hereditary renal cell carcinoma 1 | 3
Hypertensive retinopathy 1 | 9
Kidney Diseases 1 | 86
Limb Deformities, Congenital 1 | 16
Lymphoma, T-Cell, Cutaneous 1 | 21
Mammary Neoplasms, Experimental 1 | 149
Myocardial Ischemia 1 | 169
Narcolepsy 1 | 69
Patau syndrome 1 | 15
Trachoma 1 | 5
Vascular disease 1 | 281
adult high grade glioma 1 | 2,148
breast carcinoma 1 | 1,614
colon cancer 1 | 1,475
cystic fibrosis 1 | 1,670
hand, foot and mouth disease 1 | 11
inflammatory breast cancer 1 | 404
pituitary cancer 1 | 1,972
sarcoidosis 1 | 368

Tissue

Blood and immune system 57 | 17,994
Digestive Tract 57 | 18,472
Endocrine System 57 | 18,511
Female tissues 57 | 18,646
Liver and Pancreas 57 | 18,135
Male tissues 57 | 17,968
Nervous System 57 | 18,560
Urinary Tract 57 | 18,443
Cardiovascular System 56 | 17,957
Respiratory system 56 | 17,483
Skin and soft tissues 56 | 18,114

Target Family

Enzyme 39 | 4,146
Non-IDG 14 | 11,969
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

NIK-->noncanonical NF-kB signa... 57 | 57
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.25781 180.0 594
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
Proteasome activator complex subunit 1 PSME1 Tbio Non-IDG -1.72065 54.6 204
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.10500 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.62947 56.7 150
Proteasome subunit beta type-2 PSMB2 Tclin Enzyme -0.68579 4.42 180
Proteasome subunit beta type-3 PSMB3 Tchem Enzyme -0.56458 2.93 73
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.36539 20.6 94