Development Level

Tbio 34 | 10,625
Tchem 18 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 3 | 633
decreased lean body mass 2 | 195
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased bone mineral content 1 | 157
embryonic lethality prior to o... 1 | 148
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 40 | 8,484
Multiple myeloma 30 | 1,327
lung cancer 25 | 4,466
psoriasis 24 | 6,685
osteosarcoma 21 | 7,933
glioblastoma 19 | 5,572
HIV Infections 15 | 100
Cancer 13 | 2,346
dermatomyositis 13 | 933
Waldenstrons macroglobulinemia 10 | 765
Breast cancer 9 | 3,094
malignant mesothelioma 9 | 3,162
medulloblastoma, large-cell 9 | 6,234
atypical teratoid / rhabdoid tumor 8 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
astrocytoma 7 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
Mantle cell lymphoma 6 | 18
non-small cell lung cancer 6 | 2,798
oligodendroglioma 6 | 2,849
Pick disease 5 | 1,893
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
non primary Sjogren syndrome sicca 5 | 840
pediatric high grade glioma 5 | 2,712
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 1,557
astrocytic glioma 4 | 2,241
ependymoma 4 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
pancreatic cancer 4 | 2,300
pilocytic astrocytoma 4 | 3,086
primary Sjogren syndrome 4 | 789
primary pancreatic ductal adenocarcinoma 4 | 1,271
IGA Glomerulonephritis 3 | 454
acute myeloid leukemia 3 | 780
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
interstitial cystitis 3 | 2,299
lung adenocarcinoma 3 | 2,713
medulloblastoma 3 | 1,524
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674
ulcerative colitis 3 | 2,087
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
Atopic dermatitis 2 | 944
Heat Stroke 2 | 12
Mammary Neoplasms, Experimental 2 | 150
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Osteoporosis 2 | 257
Parkinson's disease 2 | 364
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Rheumatoid Arthritis 2 | 1,160
Squamous cell carcinoma of esophagus 2 | 82
Stevens-Johnson syndrome 2 | 78
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
chronic kidney disease 2 | 90
cutaneous lupus erythematosus 2 | 1,056
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 532
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Amyotrophic Lateral Sclerosis 1 | 431
Anemia 1 | 252
Ankylosing spondylitis 1 | 138
Barrett's esophagus 1 | 183
Bladder Neoplasm 1 | 109
COPD 1 | 113
Carpal tunnel syndrome 1 | 19
Cleft palate 1 | 125
Cockayne syndrome 1 | 54
Contact Dermatitis 1 | 80
Crohn Disease 1 | 97
Degenerative polyarthritis 1 | 93
Diabetes Mellitus, Non-Insulin-Dependent 1 | 157
Hypertensive retinopathy 1 | 9
Kidney Diseases 1 | 86
Limb Deformities, Congenital 1 | 16
Liver neoplasms 1 | 109
Myocardial Ischemia 1 | 169
Narcolepsy 1 | 58
Patau syndrome 1 | 15
Polycystic Ovary Syndrome 1 | 332
Vascular disease 1 | 281
adult high grade glioma 1 | 2,148
breast carcinoma 1 | 1,614
colon cancer 1 | 1,475
cystic fibrosis 1 | 1,665
hand, foot and mouth disease 1 | 11
inflammatory breast cancer 1 | 404
pituitary cancer 1 | 1,972
sarcoidosis 1 | 358
substance-related disorder 1 | 105

Tissue

Blood and immune system 58 | 17,995
Digestive Tract 58 | 18,473
Endocrine System 58 | 18,512
Female tissues 58 | 18,647
Liver and Pancreas 58 | 18,136
Male tissues 58 | 17,969
Nervous System 58 | 18,561
Urinary Tract 58 | 18,444
Cardiovascular System 57 | 17,958
Respiratory system 57 | 17,484
Skin and soft tissues 57 | 18,115

Target Family

Enzyme 40 | 4,146
Non-IDG 14 | 11,971
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

NIK-->noncanonical NF-kB signa... 58 | 58
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
NEDD8-conjugating enzyme Ubc12 UBE2M Tbio Non-IDG -1.23759 14.6 104
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.83653 71.4 158
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.35199 201.1 1028
26S protease regulatory subunit 8 PSMC5 Tbio Enzyme -1.68576 49.6 167
26S protease regulatory subunit 10B PSMC6 Tchem Enzyme -2.64753 334.8 203
26S protease regulatory subunit 4 PSMC1 Tbio Enzyme -1.11952 12.7 118