Development Level

Tbio 7 | 11,651
Tchem 4 | 1,388

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

glioblastoma 8 | 5,792
Astrocytoma, Pilocytic 7 | 3,081
Carcinoma 7 | 11,493
ependymoma 7 | 4,679
ovarian cancer 7 | 8,520
psoriasis 7 | 6,694
Cancer 6 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
adult high grade glioma 5 | 3,801
Autosomal recessive predisposition 4 | 1,442
Influenza 4 | 142
Melanoma 4 | 711
atypical teratoid / rhabdoid tumor 4 | 5,112
juvenile dermatomyositis 4 | 1,187
lung cancer 4 | 4,740
osteosarcoma 4 | 7,950
Kidney cancer 3 | 2,613
Systemic lupus erythematosus 3 | 194
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Agammaglobulinemia 2 | 34
Asthma 2 | 385
Autoimmune lymphoproliferative syndrome 2 | 11
Autoimmune lymphoproliferative syndrome type 2B 2 | 9
Chronic diarrhea 2 | 29
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Gaucher disease type 1 2 | 180
Hepatitis 2 | 67
Hyperkeratosis 2 | 50
Immunoglobulin A deficiency (disorder) 2 | 19
Immunologic Deficiency Syndromes 2 | 113
Influenza, Human 2 | 51
Lung Neoplasms 2 | 232
Microphthalmia with limb anomalies 2 | 40
Pediatric failure to thrive 2 | 365
Recurrent infections 2 | 48
SINGLETON-MERTEN SYNDROME 1 2 | 2
Seizures 2 | 596
Short stature 2 | 531
Singleton-Merten dysplasia 2 | 2
Small head 2 | 374
Type 2 diabetes mellitus 2 | 272
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
ulcerative colitis 2 | 1,819
ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) 1 | 1
Abnormal hand morphology 1 | 2
Abnormal pigmentation 1 | 25
Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 1 | 1
Asymmetric growth 1 | 5
Atrophic, patchy alopecia 1 | 1
Atypical Mycobacteriosis, Familial, X-Linked 1 1 | 1
Carcinoma, squamous cell of head and neck 1 | 31
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema 1 | 1
Ectodermal dysplasia, hypohidrotic, with immune deficiency 1 | 2
Edema 1 | 81
Hearing abnormality 1 | 12
Hyperglycemia 1 | 137
Hypohidrotic ectodermal dysplasia with immunodeficiency 1 | 2
Hypoplastic fingernails 1 | 11
INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) 1 | 1
Immunodeficiency without anhidrotic ectodermal dysplasia 1 | 1
Impaired memory B-cell generation 1 | 3
Incontinentia Pigmenti 1 | 1
Incontinentia pigmenti syndrome 1 | 1
Increased IgM levels 1 | 16
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Increased susceptibility to bacterial infections 1 | 42
Invasive pneumococcal disease, recurrent isolated, 2 1 | 1
Irregular hyperpigmentation 1 | 33
Micronodular cirrhosis 1 | 12
Onset of lymphedema around puberty 1 | 21
Oral cleft 1 | 18
Peg shaped front tooth 1 | 6
Peg-shaped incisors 1 | 6
Pointed front tooth 1 | 6
Pointed incisor 1 | 6
Prone to bacterial infection 1 | 42
Recurrent bacterial infection 1 | 42
Recurrent mycobacterium avium complex infections 1 | 2
Skin Abnormalities 1 | 37
Skin Neoplasms 1 | 69
Sotos syndrome 1 | 13
Squamous cell carcinoma of the head and neck 1 | 29
Stomach cancer 1 | 30
Subacute progressive viral hepatitis 1 | 9
Type 1 diabetes mellitus 1 | 109
Warts 1 | 10
X- linked recessive 1 | 110
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Enzyme 5 | 4,145
Kinase 4 | 634
Non-IDG 2 | 12,091

Reactome Pathway

NF-kB activation through FADD/... 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interferon-induced helicase C domain-containing protein 1 IFIH1 Tbio Enzyme -2.67869 455.3 335
Probable ATP-dependent RNA helicase DDX58 DDX58 Tbio Enzyme -2.96494 922.1 422
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
E3 ubiquitin-protein ligase RNF135 RNF135 Tbio Enzyme -1.25282 18.3 115
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Mitochondrial antiviral-signaling protein MAVS Tbio Non-IDG -2.60739 413.5 437
E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 Tbio Enzyme -2.36966 244.7 387