Development Level

Tbio 30 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
vertebral fusion 2 | 23
abnormal esophagus morphology 1 | 5
abnormal pancreas morphology 1 | 13
abnormal skin coloration 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
absent startle reflex 1 | 24
anophthalmia 1 | 33
decreased bone mineral density 1 | 126
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
increased bone mineral density 1 | 72
increased circulating total pr... 1 | 28

Disease

ovarian cancer 25 | 8,520
Carcinoma 22 | 11,493
osteosarcoma 20 | 7,950
glioblastoma 15 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
psoriasis 11 | 6,694
medulloblastoma, large-cell 10 | 6,241
Multiple myeloma 9 | 1,332
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
lung adenocarcinoma 9 | 2,716
lung cancer 9 | 4,740
Kidney cancer 8 | 2,613
Rheumatoid arthritis 8 | 1,191
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
astrocytoma 6 | 1,146
oligodendroglioma 6 | 2,850
Cancer 5 | 2,499
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
progressive supranuclear palsy 5 | 676
subependymal giant cell astrocytoma 5 | 2,287
Duchenne muscular dystrophy 4 | 601
Pick disease 4 | 1,894
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Acquired metabolic disease 3 | 336
Epilepsy 3 | 792
Prostatic Neoplasms 3 | 495
Seizures 3 | 596
acute myeloid leukemia 3 | 783
cystic fibrosis 3 | 1,696
hepatocellular carcinoma 3 | 547
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Alzheimer's disease 2 | 658
Anemia 2 | 365
Autosomal recessive predisposition 2 | 1,442
Back Pain 2 | 7
Becker muscular dystrophy 2 | 191
Cognitive delay 2 | 608
Congenital disorder of glycosylation 2 | 54
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Mental and motor retardation 2 | 608
Myocardial Ischemia 2 | 169
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
NGLY1-deficiency 2 | 4
Physical aggression 2 | 76
Pick's disease 2 | 15
Polycystic Kidney Diseases 2 | 20
Polycystic liver disease 2 | 16
Stevens-Johnson syndrome 2 | 92
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 4,104
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
non-small cell lung cancer 2 | 2,890
pancreatic carcinoma 2 | 562
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Acute coronary syndrome 1 | 39
Amyotrophic lateral sclerosis type 8 1 | 10
Apraxias 1 | 27
Cardiovascular Abnormalities 1 | 31
Cleft uvula 1 | 27
Cryptosporidiosis 1 | 13
Echolalia 1 | 12
Epidermolysis bullosa acquisita 1 | 10
Excess nuchal skin 1 | 30
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia 1 | 13
Irritation - emotion 1 | 68
Leprosy 1 | 73
Microsporidiosis 1 | 13
Neoplasms 1 | 63
Restlessness 1 | 14
Rimmed vacuoles on biopsy 1 | 15
Scapular weakness 1 | 23
Shoulder girdle muscle atrophy 1 | 6
Submucous cleft of hard palate 1 | 11
Winged scapula 1 | 23

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678

Target Family

Enzyme 21 | 4,145
Non-IDG 13 | 12,091

Reactome Pathway

N-glycan trimming in the ER an... 34 | 34
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
UDP-glucose:glycoprotein glucosyltransferase 1 UGGT1 Tbio Enzyme -1.60583 43.0 80
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase NGLY1 Tbio Enzyme -1.92615 77.4 32
E3 ubiquitin-protein ligase RNF103 RNF103 Tbio Enzyme -1.95102 35.6 76
Cytosolic endo-beta-N-acetylglucosaminidase ENGASE Tchem Enzyme -1.91874 76.6 60
Malectin MLEC Tbio Non-IDG -1.72023 48.9 81