Development Level

Tbio 6 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602

IMPC Term

decreased body weight 1 | 174
decreased mean corpuscular vol... 1 | 50
increased CD4-positive, alpha ... 1 | 15
increased body weight 1 | 42

Disease

tuberculosis 10 | 1,557
lung carcinoma 9 | 2,844
ovarian cancer 8 | 8,484
cutaneous lupus erythematosus 7 | 1,056
glioblastoma 7 | 5,572
lung cancer 7 | 4,466
psoriasis 7 | 6,685
IGA Glomerulonephritis 6 | 454
malignant mesothelioma 6 | 3,162
Asthma 5 | 349
Cancer 5 | 2,346
Malaria 5 | 140
diabetes mellitus 5 | 1,663
medulloblastoma, large-cell 5 | 6,234
osteosarcoma 5 | 7,933
pilocytic astrocytoma 5 | 3,086
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 2,087
Breast cancer 4 | 3,094
Meningitis 4 | 46
Pneumonia 4 | 133
Prostatic Neoplasms 4 | 471
Reperfusion Injury 4 | 84
Rheumatoid Arthritis 4 | 1,160
cystic fibrosis 4 | 1,665
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
pediatric high grade glioma 4 | 2,712
Arthritis 3 | 248
Colorectal Neoplasms 3 | 217
Hypersensitivity reaction type II disease 3 | 235
Inflammation 3 | 109
Inflammatory bowel disease 3 | 142
Influenza 3 | 142
Keratitis 3 | 42
Obesity 3 | 616
Perinatal necrotizing enterocolitis 3 | 18
Peritonitis 3 | 37
adrenocortical carcinoma 3 | 1,427
gastric carcinoma 3 | 832
group 4 medulloblastoma 3 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
invasive ductal carcinoma 3 | 2,950
non-small cell lung cancer 3 | 2,798
periodontitis 3 | 269
Allergic hypersensitivity disease 2 | 123
Aspergillosis 2 | 23
Atherosclerosis 2 | 275
Chorioamnionitis 2 | 15
Chronic obstructive pulmonary disease 2 | 146
Coronary artery disease 2 | 240
Dermatitis 2 | 107
Duchenne muscular dystrophy 2 | 602
Heart disease 2 | 279
Human immunodeficiency virus infectious disease 2 | 92
Invasive Pneumococcal Disease, Recurrent Isolated, 1 2 | 2
Kidney disease 2 | 396
Leishmaniasis 2 | 49
Leprosy 2 | 77
Leptospirosis 2 | 17
Liver disease 2 | 219
Lyme disease 2 | 23
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) 2 | 12
Macroglobulinemia 2 | 17
Mastitis 2 | 48
Melioidosis 2 | 11
Multiple Sclerosis 2 | 498
Neoplasm Invasiveness 2 | 127
Neoplasm Metastasis 2 | 138
Otitis media 2 | 32
Pelvic inflammatory disease 2 | 21
Staphylococcal Infections 2 | 4
Tularemia 2 | 22
aldosterone-producing adenoma 2 | 664
astrocytoma 2 | 1,493
chronic lymphosyte leukemia 2 | 232
dermatomyositis 2 | 933
fibroadenoma 2 | 557
hepatocellular carcinoma 2 | 532
lung adenocarcinoma 2 | 2,713
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
posterior fossa group B ependymoma 2 | 1,530
Adenosine deaminase deficiency 1 | 3
Brain disease 1 | 83
Common cold 1 | 63
Fatty Liver 1 | 48
Fatty liver disease 1 | 84
Hypoxia-Ischemia, Brain 1 | 5
IRAK4 Deficiency 1 | 1
Job's syndrome 1 | 4
Liver Cirrhosis 1 | 101
Neonatal abstinence syndrome 1 | 9
Non-alcoholic Fatty Liver Disease 1 | 40
ovarian neoplasm 1 | 97
uncontrolled asthma 1 | 67

Tissue

Blood and immune system 11 | 17,995
Cardiovascular System 11 | 17,958
Digestive Tract 11 | 18,473
Endocrine System 11 | 18,512
Female tissues 11 | 18,647
Liver and Pancreas 11 | 18,136
Male tissues 11 | 17,969
Nervous System 11 | 18,561
Respiratory system 11 | 17,484
Skin and soft tissues 11 | 18,115
Urinary Tract 11 | 18,444

Target Family

Non-IDG 9 | 11,971
Kinase 2 | 634

Reactome Pathway

MyD88 deficiency (TLR2/4) 11 | 11
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase BTK BTK Tclin Kinase -2.98909 1061.8 721
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.69962 490.7 314
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.17898 1606.1 561
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.21875 182.4 530
Platelet glycoprotein 4 CD36 Tchem Non-IDG -2.60542 361.5 892
Toll/interleukin-1 receptor domain-containing adapter protein TIRAP Tbio Non-IDG -1.92066 85.7 369
Monocyte differentiation antigen CD14 CD14 Tbio Non-IDG -1.95366 102.0 1838
Toll-like receptor 4 TLR4 Tchem Non-IDG -3.73821 6171.6 1142
Toll-like receptor 1 TLR1 Tbio Non-IDG -2.56083 353.3 448
Toll-like receptor 6 TLR6 Tbio Non-IDG -2.13093 120.5 653