Development Level

Tbio 53 | 11,651
Tchem 37 | 1,388
Tclin 3 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 3 | 187
decreased circulating sodium l... 3 | 22
decreased mean corpuscular vol... 3 | 79
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased vertical activity 2 | 208
increased circulating free fat... 2 | 20
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
male infertility 2 | 123
abnormal cecum morphology 1 | 7
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart shape 1 | 5
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
premature death 1 | 5
small superior vagus ganglion 1 | 74

Disease

Carcinoma 62 | 11,493
glioblastoma 58 | 5,792
ovarian cancer 58 | 8,520
osteosarcoma 51 | 7,950
Cancer 47 | 2,499
medulloblastoma, large-cell 46 | 6,241
psoriasis 45 | 6,694
atypical teratoid / rhabdoid tumor 42 | 5,112
lung cancer 38 | 4,740
ependymoma 29 | 4,679
adult high grade glioma 28 | 3,801
Breast cancer 26 | 3,578
subependymal giant cell astrocytoma 26 | 2,287
lung carcinoma 25 | 2,843
malignant mesothelioma 24 | 3,232
tuberculosis 24 | 2,010
Astrocytoma, Pilocytic 22 | 3,081
Rheumatoid arthritis 20 | 1,191
group 4 medulloblastoma 20 | 1,855
primitive neuroectodermal tumor 20 | 3,035
diabetes mellitus 19 | 1,728
group 3 medulloblastoma 19 | 4,104
astrocytic glioma 18 | 2,597
ulcerative colitis 18 | 1,819
Schizophrenia 16 | 1,160
Arthritis 15 | 290
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
oligodendroglioma 15 | 2,850
pituitary cancer 15 | 1,972
invasive ductal carcinoma 14 | 2,951
pancreatic cancer 14 | 2,398
Kidney cancer 13 | 2,613
astrocytoma 13 | 1,146
cystic fibrosis 13 | 1,696
dermatomyositis 13 | 966
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
non-small cell lung cancer 13 | 2,890
Asthma 12 | 385
Multiple myeloma 12 | 1,332
Pick disease 12 | 1,894
Vascular disease 12 | 319
acute myeloid leukemia 12 | 783
colon cancer 12 | 1,478
juvenile dermatomyositis 12 | 1,187
Cholestasis, Extrahepatic 11 | 25
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
Reperfusion Injury 11 | 86
lung adenocarcinoma 11 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Alzheimer's disease 10 | 658
Brain Ischemia 10 | 110
Liver Cirrhosis, Experimental 10 | 769
Lung Neoplasms 10 | 232
Parkinson's disease 10 | 392
Waldenstrons macroglobulinemia 10 | 765
cutaneous lupus erythematosus 10 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Obesity 9 | 678
Poor school performance 9 | 645
Seizures 9 | 596
adrenocortical carcinoma 9 | 1,428
breast carcinoma 9 | 1,638
interstitial cystitis 9 | 2,312
pediatric high grade glioma 9 | 1,064
primary pancreatic ductal adenocarcinoma 9 | 1,109
Bipolar Disorder 8 | 666
Depressive disorder 8 | 409
Disease Models, Animal 8 | 155
Immunologic Deficiency Syndromes 8 | 113
Inflammatory bowel disease 8 | 151
Mental Depression 8 | 333
Pneumonia 8 | 174
Toxic encephalopathy 8 | 141
active ulcerative colitis 8 | 764
esophageal adenocarcinoma 8 | 737
Autosomal recessive predisposition 7 | 1,442
Brain Injuries 7 | 65
Brain disease 7 | 96
Cerebrovascular disease 7 | 238
Heart disease 7 | 306
Hyperalgesia 7 | 83
Hypertension 7 | 396
Kidney disease 7 | 430
Lung disease 7 | 142
Myocardial Ischemia 7 | 169
Osteoporosis 7 | 363
active Crohn's disease 7 | 922
acute quadriplegic myopathy 7 | 1,158
gastric cancer 7 | 459
hepatocellular carcinoma 7 | 547
medulloblastoma 7 | 720
Prostatic Neoplasms 6 | 495
aldosterone-producing adenoma 6 | 665
ductal carcinoma in situ 6 | 1,745
pancreatic carcinoma 6 | 562

Tissue

Blood and immune system 94 | 16,909
Cardiovascular System 94 | 15,192
Digestive Tract 94 | 17,369
Endocrine System 94 | 18,159
Female tissues 94 | 17,400
Liver and Pancreas 94 | 16,750
Male tissues 94 | 17,142
Nervous System 94 | 16,725
Respiratory system 94 | 16,393
Skin and soft tissues 94 | 17,230
Urinary Tract 94 | 16,678

Target Family

Kinase 33 | 634
Non-IDG 31 | 12,091
Enzyme 18 | 4,145
Transcription Factor 12 | 1,400

Reactome Pathway

MyD88:Mal cascade initiated on... 94 | 94
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Platelet glycoprotein 4 CD36 Tbio Non-IDG -2.63884 376.0 1155
Interleukin-1 receptor-associated kinase 3 IRAK3 Tchem Kinase -1.86631 84.0 427
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403