Development Level

Tbio 122 | 11,445
Tclin 39 | 613
Tchem 28 | 1,598
Tdark 9 | 6,588

Collection

Ion Channel: IDG Consortium (T... 27 | 99
RFA-RM-18-021 27 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
increased startle reflex 6 | 112
abnormal behavior 5 | 298
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
decreased total body fat amoun... 4 | 207
hyperactivity 4 | 148
impaired glucose tolerance 4 | 75
decreased body weight 3 | 161
increased circulating sodium l... 3 | 71
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal vibrissa morphology 2 | 25
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
abnormal cornea morphology 1 | 31
abnormal eye size 1 | 7
abnormal facial morphology 1 | 17
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
increased anxiety-related resp... 1 | 2
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased vertical activity 1 | 24
long tibia 1 | 25
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3

Disease

Carcinoma 134 | 11,493
medulloblastoma, large-cell 98 | 6,241
glioblastoma 97 | 5,792
atypical teratoid / rhabdoid tumor 92 | 5,112
psoriasis 91 | 6,694
ovarian cancer 85 | 8,520
osteosarcoma 81 | 7,950
ependymoma 78 | 4,679
adult high grade glioma 72 | 3,801
group 3 medulloblastoma 68 | 4,104
Astrocytoma, Pilocytic 66 | 3,081
lung cancer 62 | 4,740
primitive neuroectodermal tumor 61 | 3,035
Breast cancer 55 | 3,578
oligodendroglioma 54 | 2,850
lung carcinoma 52 | 2,843
Kidney cancer 51 | 2,613
subependymal giant cell astrocytoma 49 | 2,287
astrocytic glioma 46 | 2,597
lung adenocarcinoma 46 | 2,716
malignant mesothelioma 46 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
invasive ductal carcinoma 45 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
Pick disease 41 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
pituitary cancer 40 | 1,972
colon cancer 39 | 1,478
pancreatic cancer 35 | 2,398
Atrial Fibrillation 33 | 124
acute quadriplegic myopathy 32 | 1,158
cystic fibrosis 31 | 1,696
Autosomal recessive predisposition 30 | 1,442
Epilepsy 29 | 792
non-small cell lung cancer 29 | 2,890
Cardiomyopathy 26 | 116
ductal carcinoma in situ 26 | 1,745
group 4 medulloblastoma 25 | 1,855
Heart disease 24 | 306
breast carcinoma 24 | 1,638
diabetes mellitus 24 | 1,728
Hypertension 23 | 396
Myopathy 23 | 185
adrenocortical carcinoma 23 | 1,428
Cancer 22 | 2,499
Duchenne muscular dystrophy 21 | 601
Skin cancer 21 | 469
ulcerative colitis 21 | 1,819
Hypertrophic Cardiomyopathy 20 | 117
interstitial cystitis 20 | 2,312
Cardiomyopathy, Dilated 19 | 83
Melanoma 19 | 711
Seizures 19 | 596
tuberculosis 19 | 2,010
Dilated cardiomyopathy 18 | 56
Hypertensive disease 18 | 292
Liver cancer 18 | 604
Brugada syndrome 17 | 29
Congestive heart failure 17 | 113
juvenile dermatomyositis 17 | 1,187
Amyotrophic lateral sclerosis 16 | 451
Cardiomegaly 16 | 116
Long QT syndrome 16 | 39
Muscle hypotonia 16 | 571
astrocytoma 16 | 1,146
primary pancreatic ductal adenocarcinoma 16 | 1,109
Endometrial cancer 15 | 311
Cardiac Arrhythmia 14 | 103
Familial atrial fibrillation 14 | 23
Familial isolated dilated cardiomyopathy 14 | 41
LEFT VENTRICULAR NONCOMPACTION 10 14 | 40
LEFT VENTRICULAR NONCOMPACTION 8 14 | 40
Liver Cirrhosis, Experimental 14 | 769
Schizophrenia 14 | 1,160
Status Epilepticus 14 | 98
Ventricular arrhythmia 14 | 27
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 13 | 21
Atopic dermatitis 13 | 952
Bipolar Disorder 13 | 666
Cerebellar Ataxia 13 | 304
Rheumatoid arthritis 13 | 1,191
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
dermatomyositis 13 | 966
fibroadenoma 13 | 559
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Cognitive delay 12 | 608
Distal arthrogryposis 12 | 42
Global developmental delay 12 | 608
Heart failure 12 | 162
Mental and motor retardation 12 | 608
non primary Sjogren syndrome sicca 12 | 891
pediatric high grade glioma 12 | 1,064
Acquired scoliosis 11 | 281
Becker muscular dystrophy 11 | 191
Curvature of spine 11 | 282
Heart conduction disease 11 | 83
Intellectual disability 11 | 1,016
Life-Threatening Ventricular Tachycardia 11 | 15
Parkinson's disease 11 | 392
Primary cutaneous amyloidosis 11 | 29

Tissue

Endocrine System 197 | 18,159
Digestive Tract 191 | 17,369
Female tissues 188 | 17,400
Male tissues 188 | 17,142
Nervous System 186 | 16,725
Skin and soft tissues 186 | 17,230
Blood and immune system 182 | 16,909
Urinary Tract 182 | 16,678
Liver and Pancreas 179 | 16,750
Respiratory system 174 | 16,393
Cardiovascular System 169 | 15,192

Target Family

Ion Channel 81 | 344
Non-IDG 75 | 12,091
Transporter 17 | 473
Kinase 14 | 634
Enzyme 7 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Muscle contraction 198 | 198
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Potassium voltage-gated channel subfamily E member 4 KCNE4 Tbio Ion Channel -1.17671 15.9 99
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Potassium voltage-gated channel subfamily E member 3 KCNE3 Tbio Ion Channel -1.63683 41.4 75
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162