Development Level

Tbio 105 | 10,625
Tchem 43 | 1,890
Tclin 40 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 31 | 117

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal behavior 4 | 226
decreased body weight 3 | 174
embryonic lethality prior to t... 3 | 187
hyperactivity 3 | 108
increased circulating sodium l... 3 | 71
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
abnormal retina morphology 2 | 100
abnormal vibrissa morphology 2 | 17
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased startle reflex 2 | 38
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
cyanosis 1 | 6
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
edema 1 | 11
hemorrhage 1 | 12
increased blood uric acid leve... 1 | 5
increased body weight 1 | 42
increased caudal vertebrae num... 1 | 8
increased circulating alkaline... 1 | 119
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased effector memory CD4-... 1 | 15
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased kidney weight 1 | 4
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
short tibia 1 | 82
small epididymis 1 | 3

Disease

medulloblastoma, large-cell 96 | 6,234
glioblastoma 91 | 5,572
psoriasis 90 | 6,685
ovarian cancer 82 | 8,484
osteosarcoma 79 | 7,933
atypical teratoid / rhabdoid tumor 74 | 4,369
pilocytic astrocytoma 64 | 3,086
lung cancer 59 | 4,466
primitive neuroectodermal tumor 59 | 3,031
oligodendroglioma 53 | 2,849
lung carcinoma 52 | 2,844
Carcinoma 51 | 2,147
subependymal giant cell astrocytoma 48 | 2,287
lung adenocarcinoma 47 | 2,713
pediatric high grade glioma 47 | 2,712
invasive ductal carcinoma 45 | 2,950
ependymoma 44 | 2,514
Breast cancer 43 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
malignant mesothelioma 42 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,956
Pick disease 40 | 1,893
colon cancer 40 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
pituitary cancer 40 | 1,972
astrocytic glioma 38 | 2,241
adult high grade glioma 35 | 2,148
posterior fossa group A ependymoma 33 | 1,511
Atrial Fibrillation 31 | 110
acute quadriplegic myopathy 31 | 1,157
cystic fibrosis 29 | 1,665
medulloblastoma 29 | 1,524
pancreatic cancer 29 | 2,300
ductal carcinoma in situ 27 | 1,745
non-small cell lung cancer 27 | 2,798
group 3 medulloblastoma 26 | 2,254
group 4 medulloblastoma 25 | 1,875
ulcerative colitis 25 | 2,087
Cardiomyopathy 23 | 110
adrenocortical carcinoma 23 | 1,427
astrocytoma 23 | 1,493
breast carcinoma 23 | 1,614
diabetes mellitus 23 | 1,663
sonic hedgehog group medulloblastoma 23 | 1,482
Epilepsy 22 | 346
Heart disease 22 | 279
Cancer 21 | 2,346
Duchenne muscular dystrophy 21 | 602
atypical teratoid/rhabdoid tumor 20 | 1,095
interstitial cystitis 20 | 2,299
primary pancreatic ductal adenocarcinoma 20 | 1,271
Hypertrophic Cardiomyopathy 19 | 56
Long QT syndrome 19 | 52
Dilated cardiomyopathy 18 | 50
Myopathy 18 | 128
juvenile dermatomyositis 16 | 1,189
Amyotrophic Lateral Sclerosis 15 | 431
Brugada syndrome 15 | 26
Hypertension 14 | 287
Hypertensive disease 14 | 193
Atopic dermatitis 13 | 944
Distal arthrogryposis 13 | 45
Rheumatoid Arthritis 13 | 1,160
Status Epilepticus 13 | 85
dermatomyositis 13 | 933
fibroadenoma 13 | 557
non primary Sjogren syndrome sicca 13 | 840
tuberculosis 13 | 1,557
Cardiomyopathy, Hypertrophic, Familial 12 | 21
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
posterior fossa group B ependymoma 12 | 1,530
Becker muscular dystrophy 11 | 187
Cardiomyopathy, Dilated 11 | 47
Familial atrial fibrillation 11 | 16
Life-Threatening Ventricular Tachycardia 11 | 15
Primary cutaneous amyloidosis 11 | 26
Short QT syndrome 11 | 12
Cough 10 | 21
Dysuria 10 | 24
Epilepsy characterized by intractable complex partial seizures 10 | 28
Heart conduction disease 10 | 65
Itching of skin 10 | 19
Lennox-Gastaut syndrome 10 | 34
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea pedis 10 | 30
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 14
aldosterone-producing adenoma 10 | 664
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
spina bifida 10 | 1,064

Tissue

Nervous System 197 | 18,561
Female tissues 196 | 18,647
Cardiovascular System 195 | 17,958
Digestive Tract 195 | 18,473
Endocrine System 195 | 18,512
Liver and Pancreas 195 | 18,136
Urinary Tract 195 | 18,444
Blood and immune system 193 | 17,995
Male tissues 193 | 17,969
Skin and soft tissues 192 | 18,115
Respiratory system 191 | 17,484

Target Family

Ion Channel 81 | 341
Non-IDG 75 | 11,971
Transporter 18 | 473
Kinase 12 | 634
Enzyme 7 | 4,146
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Muscle contraction 197 | 197
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Myosin light chain 6B MYL6B Tdark Non-IDG -0.43175 2.57 113
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.62325 4.93 166
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2 Tclin Transporter -2.04732 117.9 108
Voltage-dependent calcium channel gamma-7 subunit CACNG7 Tchem Ion Channel -0.48027 2.02 53
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 Tchem Ion Channel -1.00872 12.4 65