Development Level

Tclin 4 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

abnormal behavior 1 | 298
hyperactivity 1 | 148

Disease

Biliary dyskinesia 4 | 7
Carcinoma 4 | 11,493
Chronic gastritis 4 | 5
Chronic obstructive lung disease 4 | 6
Excessive salivation 4 | 5
Gastric ulcer 4 | 33
General anesthesia 4 | 53
Peptic Ulcer 4 | 27
Urinary Incontinence 4 | 50
Vagal Reflex Bradycardia 4 | 5
Schizophrenia 3 | 1,160
psoriasis 3 | 6,694
Acute cystitis 2 | 35
Bipolar Disorder 2 | 666
Bladder muscle dysfunction - overactive 2 | 4
Cholinesterase Inhibitors Toxicity 2 | 4
Dysuria 2 | 26
Epilepsy 2 | 792
Gastrointestinal Radiography Adjunct 2 | 11
Increased Urinary Frequency 2 | 11
Major Depressive Disorder 2 | 301
Mood Disorders 2 | 184
Muscarine Toxicity 2 | 3
Perioperative Mydriasis 2 | 3
Retention of urine 2 | 3
Sinus bradycardia 2 | 7
Urge incontinence of urine 2 | 3
Urgent desire to urinate 2 | 11
Urinary Tract Irritation 2 | 24
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
Abnormality of the ribs 1 | 32
Alcohol dependence 1 | 107
Alcoholic Intoxication, Chronic 1 | 289
Aplasia/Hypoplasia of the lungs 1 | 13
Ascending cholangitis 1 | 3
Ascites 1 | 22
Bradycardia 1 | 36
Brain Injuries 1 | 65
Bronchitis 1 | 43
Bronchospasm 1 | 9
Chemical and Drug Induced Liver Injury 1 | 195
Cholinergic urticaria 1 | 5
Chronic Obstructive Pulmonary Disease with Bronchospasms 1 | 8
Chronic bronchitis 1 | 4
Cocaine-Related Disorders 1 | 92
Congenital Heart Defects 1 | 58
Congenital clubfoot 1 | 109
Congenital heart disease 1 | 93
Congenital pectus carinatum 1 | 52
Congenital posterior urethral valves 1 | 2
Constipation 1 | 181
Cycloplegia 1 | 12
Decreased fertility 1 | 33
Dermatologic disorders 1 | 93
Diabetes Mellitus, Experimental 1 | 108
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Type 1 1 | 43
Diabetic Neuropathies 1 | 14
Dilatation of ureter 1 | 15
Dilated pupil 1 | 6
Dyschezia 1 | 135
Enterocolitis 1 | 8
Hip Dislocation, Congenital 1 | 48
Hydronephrosis 1 | 89
Irritable bowel syndrome 1 | 60
Kidney Failure 1 | 111
Liver Cirrhosis 1 | 181
Marijuana Abuse 1 | 31
Melanoma 1 | 711
Myopia 1 | 176
Nasal discharge 1 | 24
Neurogenic Urinary Bladder 1 | 6
Neurogenic bladder 1 | 16
Neuroleptic-induced Parkinsonism 1 | 1
Ocular hypertension 1 | 42
Open-angle glaucoma 1 | 27
Pain agnosia 1 | 104
Pulmonary emphysema 1 | 48
Pyelonephritis 1 | 13
Recurrent respiratory infections 1 | 141
Recurrent urinary tract infection 1 | 24
Renal Insufficiency 1 | 90
Renal failure in adulthood 1 | 76
Schistosomiasis 1 | 35
Skin Abnormalities 1 | 37
Skin cancer 1 | 469
Small testicle 1 | 75
Substance Withdrawal Syndrome 1 | 55
Substance-Related Disorders 1 | 115
Tremor 1 | 113
Urinary Bladder Diseases 1 | 5
Urinary Bladder, Neurogenic 1 | 1
Urinary tract obstruction 1 | 11
Urofacial syndrome 1 | 7
Uroureter 1 | 15
Vesico-Ureteral Reflux 1 | 33
Xerostomia 1 | 42
Xerostomia Secondary to Sjogren's Syndrome 1 | 2

Tissue

Blood and immune system 4 | 16,909
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Male tissues 3 | 17,142
Urinary Tract 3 | 16,678
Cardiovascular System 2 | 15,192

Target Family

GPCR 4 | 408

Reactome Pathway

Muscarinic acetylcholine recep... 4 | 4
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Muscarinic acetylcholine receptor M5 CHRM5 Tclin GPCR -1.35374 22.9 141
Muscarinic acetylcholine receptor M2 CHRM2 Tclin GPCR -2.70017 498.2 391
Muscarinic acetylcholine receptor M4 CHRM4 Tclin GPCR -1.90995 79.8 130
Muscarinic acetylcholine receptor M3 CHRM3 Tclin GPCR -2.65353 447.9 234