Development Level

Tbio 22 | 10,625
Tchem 5 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

increased leukocyte cell numbe... 2 | 37
preweaning lethality, complete... 2 | 633
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal incisor morphology 1 | 3
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
hydrops fetalis 1 | 22
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 18 | 8,484
lung carcinoma 17 | 2,844
osteosarcoma 16 | 7,933
psoriasis 16 | 6,685
atypical teratoid / rhabdoid tumor 14 | 4,369
glioblastoma 14 | 5,572
pancreatic cancer 14 | 2,300
lung cancer 13 | 4,466
malignant mesothelioma 13 | 3,162
medulloblastoma, large-cell 13 | 6,234
primary pancreatic ductal adenocarcinoma 13 | 1,271
Cancer 12 | 2,346
lung adenocarcinoma 12 | 2,713
non-small cell lung cancer 12 | 2,798
pilocytic astrocytoma 12 | 3,086
Breast cancer 11 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
invasive ductal carcinoma 11 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
pediatric high grade glioma 10 | 2,712
colon cancer 9 | 1,475
ductal carcinoma in situ 9 | 1,745
Atopic dermatitis 8 | 944
ependymoma 8 | 2,514
Endometriosis 7 | 535
adrenocortical carcinoma 7 | 1,427
breast carcinoma 7 | 1,614
cutaneous lupus erythematosus 7 | 1,056
cystic fibrosis 7 | 1,665
pituitary cancer 7 | 1,972
sonic hedgehog group medulloblastoma 7 | 1,482
Prostatic Neoplasms 6 | 471
diabetes mellitus 6 | 1,663
interstitial cystitis 6 | 2,299
posterior fossa group A ependymoma 6 | 1,511
Cleft palate 5 | 125
Duchenne muscular dystrophy 5 | 602
Osteoporosis 5 | 257
group 3 medulloblastoma 5 | 2,254
oligodendroglioma 5 | 2,849
tuberculosis 5 | 1,557
Acquired metabolic disease 4 | 267
Aortic aneurysm 4 | 34
Colorectal Neoplasms 4 | 217
Osteoarthritis 4 | 96
Pulmonary emphysema 4 | 34
adult high grade glioma 4 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
group 4 medulloblastoma 4 | 1,875
limb girdle muscular dystrophy 2A 4 | 156
Age related macular degeneration 3 | 84
Ankylosis 3 | 25
Arthritis 3 | 248
Cerebrovascular accident 3 | 44
Cleft Lip 3 | 91
Cutis laxa 3 | 28
Degenerative disc disease 3 | 28
Degenerative polyarthritis 3 | 93
Down syndrome 3 | 548
Glanzmann's thrombasthenia 3 | 21
Glaucoma 3 | 134
Liver Cirrhosis, Experimental 3 | 108
Mammary Neoplasms 3 | 410
Neuropathy 3 | 210
Proliferative vitreoretinopathy 3 | 17
Pulmonary Fibrosis 3 | 66
Rheumatoid Arthritis 3 | 1,160
Stomach Neoplasms 3 | 282
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
astrocytoma 3 | 1,493
dermatomyositis 3 | 933
fascioscapulohumeral muscular dystrophy 3 | 100
gastric carcinoma 3 | 832
nasopharyngeal carcinoma 3 | 1,056
pancreatic carcinoma 3 | 567
posterior fossa group B ependymoma 3 | 1,530
primitive neuroectodermal tumor 3 | 3,031
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Atherosclerosis 2 | 275
Cerebrovascular disease 2 | 231
Coronary artery disease 2 | 240
Craniosynostosis 2 | 47
Hypertension 2 | 287
Kidney disease 2 | 396
Lung Neoplasms 2 | 171
Multiple Sclerosis 2 | 498
Neoplasm Metastasis 2 | 138
Pancreatic Neoplasm 2 | 79
Spontaneous abortion 2 | 108
atypical teratoid/rhabdoid tumor 2 | 1,095
fibroadenoma 2 | 557
head and neck cancer 2 | 270
hereditary spastic paraplegia 2 | 313
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480
non-small cell lung carcinoma 2 | 413
pterygium 2 | 74

Tissue

Cardiovascular System 30 | 17,958
Digestive Tract 30 | 18,473
Endocrine System 30 | 18,512
Female tissues 30 | 18,647
Liver and Pancreas 30 | 18,136
Male tissues 30 | 17,969
Nervous System 30 | 18,561
Respiratory system 30 | 17,484
Skin and soft tissues 30 | 18,115
Urinary Tract 30 | 18,444
Blood and immune system 29 | 17,995

Target Family

Non-IDG 29 | 11,971
Transcription Factor 1 | 1,400

Reactome Pathway

Molecules associated with elas... 30 | 30
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.59556 4267.5 575
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.16723 1539.5 438
Integrin beta-8 ITGB8 Tbio Non-IDG -1.29874 21.7 68
EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2 Tbio Non-IDG -1.58529 46.2 203
EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 Tbio Non-IDG -2.11121 148.3 205
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -4.32707 20956.6 961
Fibulin-2 FBLN2 Tbio Non-IDG -1.68871 51.2 168
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.80325 67.0 98
Latent-transforming growth factor beta-binding protein 2 LTBP2 Tbio Non-IDG -1.13380 15.6 86
Integrin alpha-8 ITGA8 Tbio Non-IDG -1.29251 19.3 110