Development Level

Tbio 75 | 10,625
Tdark 17 | 7,003
Tchem 15 | 1,890

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 9 | 633
decreased body weight 2 | 174
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
abnormal cornea morphology 1 | 24
abnormal eye pigmentation 1 | 2
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
corneal opacity 1 | 25
corneal vascularization 1 | 5
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased eosinophil cell numb... 1 | 41
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
increased B cell number 1 | 23
increased circulating amylase ... 1 | 13
increased circulating iron lev... 1 | 25
increased heart weight 1 | 37
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
narrow eye opening 1 | 15
thrombocytosis 1 | 23
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 56 | 8,484
lung cancer 54 | 4,466
medulloblastoma, large-cell 49 | 6,234
osteosarcoma 49 | 7,933
glioblastoma 40 | 5,572
psoriasis 40 | 6,685
Breast cancer 35 | 3,094
atypical teratoid / rhabdoid tumor 33 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
primitive neuroectodermal tumor 28 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
invasive ductal carcinoma 26 | 2,950
lung adenocarcinoma 26 | 2,713
group 3 medulloblastoma 24 | 2,254
non-small cell lung cancer 24 | 2,798
malignant mesothelioma 21 | 3,162
pediatric high grade glioma 21 | 2,712
Cancer 20 | 2,346
Multiple myeloma 20 | 1,327
breast carcinoma 20 | 1,614
ductal carcinoma in situ 18 | 1,745
oligodendroglioma 18 | 2,849
Waldenstrons macroglobulinemia 16 | 765
adrenocortical carcinoma 16 | 1,427
astrocytic glioma 15 | 2,241
dermatomyositis 15 | 933
Carcinoma 14 | 2,147
astrocytoma 14 | 1,493
colon cancer 13 | 1,475
group 4 medulloblastoma 13 | 1,875
nasopharyngeal carcinoma 13 | 1,056
ependymoma 12 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
pancreatic cancer 12 | 2,300
pilocytic astrocytoma 12 | 3,086
Atopic dermatitis 11 | 944
Rheumatoid Arthritis 11 | 1,160
posterior fossa group A ependymoma 11 | 1,511
sonic hedgehog group medulloblastoma 11 | 1,482
subependymal giant cell astrocytoma 11 | 2,287
IGA Glomerulonephritis 10 | 454
Pick disease 10 | 1,893
acute quadriplegic myopathy 9 | 1,157
atypical teratoid/rhabdoid tumor 9 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Endometriosis 8 | 535
adult high grade glioma 8 | 2,148
lung carcinoma 8 | 2,844
medulloblastoma 8 | 1,524
cystic fibrosis 7 | 1,665
primary Sjogren syndrome 7 | 789
spina bifida 7 | 1,064
ulcerative colitis 7 | 2,087
Emery-Dreifuss muscular dystrophy 6 | 24
Lipodystrophy 6 | 32
cutaneous lupus erythematosus 6 | 1,056
diabetes mellitus 6 | 1,663
interstitial cystitis 6 | 2,299
non-small cell lung carcinoma 6 | 413
pituitary cancer 6 | 1,972
tuberculosis 6 | 1,557
tuberculosis and treatment for 6 months 6 | 686
Amyotrophic Lateral Sclerosis 5 | 431
Intellectual disability 5 | 573
progressive supranuclear palsy 5 | 674
Cardiomyopathies 4 | 90
Cardiomyopathy 4 | 110
Cleft palate 4 | 125
Mammary Neoplasms 4 | 410
Myocardial Ischemia 4 | 169
Progeria 4 | 22
Stomach Neoplasms 4 | 282
Vaccinia 4 | 37
acute myeloid leukemia 4 | 780
esophageal adenocarcinoma 4 | 737
hereditary spastic paraplegia 4 | 313
juvenile dermatomyositis 4 | 1,189
non primary Sjogren syndrome sicca 4 | 840
posterior fossa group B ependymoma 4 | 1,530
Brain Ischemia 3 | 87
Connective tissue disease 3 | 59
Dilated cardiomyopathy 3 | 50
Down syndrome 3 | 548
Gaucher disease type 1 3 | 171
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lupus erythematosus 3 | 80
Microcephaly 3 | 149
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 332
Prostatic Neoplasms 3 | 471
Werner syndrome 3 | 29
aldosterone-producing adenoma 3 | 664
gastric cancer 3 | 430
gastric carcinoma 3 | 832
pancreatic carcinoma 3 | 567
sarcoidosis 3 | 358
tuberculosis and treatment for 3 months 3 | 327
hepatocellular carcinoma 2 | 532
mucosa-associated lymphoid tissue lymphoma 2 | 480

Tissue

Female tissues 107 | 18,647
Male tissues 107 | 17,969
Blood and immune system 106 | 17,995
Cardiovascular System 106 | 17,958
Endocrine System 106 | 18,512
Nervous System 106 | 18,561
Digestive Tract 105 | 18,473
Liver and Pancreas 105 | 18,136
Urinary Tract 105 | 18,444
Respiratory system 104 | 17,484
Skin and soft tissues 97 | 18,115

Target Family

Non-IDG 78 | 11,971
Enzyme 15 | 4,146
Kinase 12 | 634
Epigenetic 2 | 242

Reactome Pathway

Mitotic Prophase 107 | 107
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Emerin EMD Tbio Non-IDG -2.77469 617.6 238
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94177 80.5 168
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -0.99049 10.1 66
Ras-related protein Rab-1B RAB1B Tbio Enzyme 36.3 104
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Ras-related protein Rab-1A RAB1A Tbio Enzyme -2.35747 242.5 102