Development Level

Tbio 78 | 11,178
Tchem 15 | 1,885
Tdark 14 | 6,569

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eye pigmentation 1 | 3
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased basophil cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9
increased urine microalbumin l... 1 | 2
urinary bladder obstruction 1 | 4

Disease

Carcinoma 67 | 11,192
ovarian cancer 57 | 8,297
lung cancer 54 | 4,607
medulloblastoma, large-cell 49 | 6,086
osteosarcoma 48 | 7,766
glioblastoma 41 | 5,635
psoriasis 41 | 6,514
atypical teratoid / rhabdoid tumor 40 | 4,971
group 3 medulloblastoma 38 | 4,002
Breast cancer 36 | 3,469
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,204
primitive neuroectodermal tumor 28 | 2,957
invasive ductal carcinoma 26 | 2,867
lung adenocarcinoma 26 | 2,627
non-small cell lung cancer 25 | 2,799
adult high grade glioma 22 | 3,701
ependymoma 22 | 4,559
Cancer 21 | 2,388
malignant mesothelioma 21 | 3,135
Multiple myeloma 20 | 1,296
astrocytic glioma 20 | 2,530
breast carcinoma 20 | 1,589
oligodendroglioma 19 | 2,768
Kidney cancer 18 | 2,548
ductal carcinoma in situ 18 | 1,686
Waldenstrons macroglobulinemia 16 | 742
adrenocortical carcinoma 16 | 1,385
dermatomyositis 15 | 941
colon cancer 13 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,872
nasopharyngeal carcinoma 13 | 1,024
pancreatic cancer 13 | 2,322
Astrocytoma, Pilocytic 12 | 3,006
group 4 medulloblastoma 12 | 1,806
tuberculosis 12 | 1,963
Atopic dermatitis 11 | 915
subependymal giant cell astrocytoma 11 | 2,230
Pick disease 10 | 1,856
Rheumatoid arthritis 10 | 1,156
acute quadriplegic myopathy 10 | 1,133
astrocytoma 10 | 1,113
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
Endometriosis 9 | 521
Intellectual disability 9 | 998
lung carcinoma 8 | 2,755
Autosomal recessive predisposition 7 | 1,407
Lipodystrophy 7 | 37
cystic fibrosis 7 | 1,629
pediatric high grade glioma 7 | 1,035
spina bifida 7 | 1,053
Amyotrophic lateral sclerosis 6 | 437
Dull intelligence 6 | 634
Emery-Dreifuss muscular dystrophy 6 | 22
Low intelligence 6 | 634
Lung Neoplasms 6 | 217
Mental Retardation 6 | 634
Mental deficiency 6 | 634
Poor school performance 6 | 634
Schizophrenia 6 | 1,136
cutaneous lupus erythematosus 6 | 1,016
diabetes mellitus 6 | 1,683
interstitial cystitis 6 | 2,237
pituitary cancer 6 | 1,915
primary Sjogren syndrome 6 | 710
Cleft Palate 5 | 265
Cognitive delay 5 | 596
Failure to gain weight 5 | 359
Global developmental delay 5 | 596
Liver Cirrhosis, Experimental 5 | 733
Mammary Neoplasms 5 | 403
Mental and motor retardation 5 | 596
Pediatric failure to thrive 5 | 359
Short stature 5 | 514
non primary Sjogren syndrome sicca 5 | 861
non-small cell lung carcinoma 5 | 302
posterior fossa group A ependymoma 5 | 456
progressive supranuclear palsy 5 | 656
Cardiomyopathy 4 | 116
Disease Models, Animal 4 | 148
Fetal Growth Retardation 4 | 186
Infant, Small for Gestational Age 4 | 174
Intrauterine retardation 4 | 174
Leukemia 4 | 103
Muscle hypotonia 4 | 562
Myocardial Ischemia 4 | 162
Orbital separation excessive 4 | 240
Parkinson's disease 4 | 378
Progressive disorder 4 | 139
Stomach Neoplasms 4 | 287
active ulcerative colitis 4 | 736
acute myeloid leukemia 4 | 760
esophageal adenocarcinoma 4 | 696
gastric cancer 4 | 445
hereditary spastic paraplegia 4 | 313
juvenile dermatomyositis 4 | 1,147
pancreatic carcinoma 4 | 555
sonic hedgehog group medulloblastoma 4 | 459
tuberculosis and treatment for 6 months 4 | 399
ulcerative colitis 4 | 1,765

Tissue

Endocrine System 105 | 18,159
Blood and immune system 104 | 16,909
Digestive Tract 104 | 17,369
Female tissues 104 | 17,400
Skin and soft tissues 104 | 17,230
Cardiovascular System 103 | 15,192
Liver and Pancreas 103 | 16,750
Male tissues 103 | 17,142
Nervous System 103 | 16,725
Respiratory system 103 | 16,393
Urinary Tract 103 | 16,678

Target Family

Non-IDG 78 | 12,091
Enzyme 15 | 4,145
Kinase 12 | 634
Epigenetic 2 | 242

Reactome Pathway

Mitotic Prophase 107 | 107
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Serine/threonine-protein kinase greatwall MASTL Tbio Kinase -2.17166 152.5 259
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Nuclear pore complex protein Nup93 NUP93 Tbio Non-IDG -1.35565 22.2 62
Serine/threonine-protein kinase Nek7 NEK7 Tchem Kinase -1.31475 20.8 261
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11
Nuclear envelope pore membrane protein POM 121 POM121 Tbio Non-IDG -1.63036 38.7 49