Development Level

Tbio 108 | 10,625
Tchem 45 | 1,890
Tdark 16 | 7,003
Tclin 8 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 6 | 187
decreased body weight 4 | 174
embryonic lethality prior to o... 4 | 148
abnormal head morphology 3 | 10
decreased bone mineral content 3 | 157
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
increased mean corpuscular vol... 3 | 91
abnormal cranium morphology 2 | 32
abnormal spleen morphology 2 | 36
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating total pr... 2 | 41
increased circulating alkaline... 2 | 119
increased mean corpuscular hem... 2 | 93
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal snout morphology 1 | 18
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
decreased basophil cell number 1 | 11
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
small testis 1 | 37
urinary bladder obstruction 1 | 2
vertebral fusion 1 | 23

Disease

ovarian cancer 124 | 8,491
osteosarcoma 88 | 7,933
psoriasis 82 | 6,685
lung cancer 69 | 4,473
medulloblastoma, large-cell 67 | 6,234
glioblastoma 66 | 5,572
malignant mesothelioma 53 | 3,163
atypical teratoid / rhabdoid tumor 50 | 4,369
Breast cancer 49 | 3,098
Cancer 48 | 2,346
Multiple myeloma 43 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
primitive neuroectodermal tumor 42 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
pediatric high grade glioma 38 | 2,712
non-small cell lung cancer 37 | 2,798
group 3 medulloblastoma 35 | 2,254
colon cancer 32 | 1,475
oligodendroglioma 32 | 2,849
lung adenocarcinoma 30 | 2,714
ependymoma 27 | 2,514
invasive ductal carcinoma 27 | 2,950
Pick disease 26 | 1,893
pancreatic cancer 25 | 2,300
sonic hedgehog group medulloblastoma 25 | 1,482
adrenocortical carcinoma 24 | 1,427
astrocytic glioma 22 | 2,241
ductal carcinoma in situ 22 | 1,745
pilocytic astrocytoma 22 | 3,086
Carcinoma 21 | 2,147
Waldenstrons macroglobulinemia 21 | 764
breast carcinoma 21 | 1,614
nasopharyngeal carcinoma 21 | 1,056
posterior fossa group A ependymoma 21 | 1,511
subependymal giant cell astrocytoma 21 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
dermatomyositis 19 | 966
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
HIV Infections 17 | 99
astrocytoma 17 | 1,493
ulcerative colitis 17 | 2,087
tuberculosis 16 | 1,563
Intellectual disability 15 | 573
diabetes mellitus 15 | 1,663
interstitial cystitis 15 | 2,299
Atopic dermatitis 14 | 944
Endometriosis 14 | 535
Microcephaly 14 | 149
posterior fossa group B ependymoma 14 | 1,530
adult high grade glioma 13 | 2,148
atypical teratoid/rhabdoid tumor 13 | 1,095
juvenile dermatomyositis 13 | 1,189
non primary Sjogren syndrome sicca 13 | 840
IGA Glomerulonephritis 11 | 454
acute myeloid leukemia 11 | 785
esophageal adenocarcinoma 11 | 737
medulloblastoma 11 | 1,524
tuberculosis and treatment for 6 months 11 | 686
Obesity 10 | 616
Rheumatoid Arthritis 10 | 1,170
acute quadriplegic myopathy 10 | 1,157
pituitary cancer 10 | 1,972
progressive supranuclear palsy 10 | 674
Mammary Neoplasms 9 | 410
group 4 medulloblastoma 9 | 1,875
primary Sjogren syndrome 9 | 788
Peripheral Neuropathy 8 | 303
cutaneous lupus erythematosus 8 | 1,056
primary pancreatic ductal adenocarcinoma 8 | 1,271
Neurodegenerative disease 7 | 383
Schizophrenia 7 | 503
lung carcinoma 7 | 2,844
pancreatic carcinoma 7 | 567
Amyotrophic Lateral Sclerosis 6 | 432
Duchenne muscular dystrophy 6 | 602
Joubert syndrome 6 | 62
Melanoma 6 | 261
Seckel syndrome 6 | 35
Squamous cell carcinoma of esophagus 6 | 82
hepatocellular carcinoma 6 | 550
spina bifida 6 | 1,064
Bardet-Biedl Syndrome 5 | 40
Lissencephaly 5 | 61
Mantle cell lymphoma 5 | 20
Nephronophthisis 5 | 74
Neuroblastoma 5 | 78
active Crohn's disease 5 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
chronic rhinosinusitis 5 | 512
gastric cancer 5 | 436
gastric carcinoma 5 | 832
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
Crohn's disease 4 | 304
Miller-Dieker lissencephaly syndrome 4 | 20
Myocardial Ischemia 4 | 169
Prostatic Neoplasms 4 | 471
Senior-Loken syndrome 4 | 22
aldosterone-producing adenoma 4 | 664
cystic fibrosis 4 | 1,670

Tissue

Blood and immune system 177 | 17,994
Endocrine System 177 | 18,511
Female tissues 177 | 18,646
Male tissues 177 | 17,968
Nervous System 177 | 18,560
Cardiovascular System 176 | 17,957
Digestive Tract 176 | 18,472
Liver and Pancreas 176 | 18,135
Urinary Tract 176 | 18,443
Respiratory system 174 | 17,483
Skin and soft tissues 174 | 18,114

Target Family

Non-IDG 99 | 11,969
Enzyme 58 | 4,146
Kinase 14 | 634
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Mitotic G2-G2/M phases 177 | 177
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HAUS augmin-like complex subunit 8 HAUS8 Tbio Non-IDG 1.00 0.07 117
HAUS augmin-like complex subunit 7 HAUS7 Tbio Non-IDG -0.21560 1.53 128
HAUS augmin-like complex subunit 2 HAUS2 Tdark Non-IDG 1.15 0.07 35
Centrosomal protein of 41 kDa CEP41 Tdark Non-IDG -0.38839 3.35 44
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.75708 61.0 81
Gamma-tubulin complex component 5 TUBGCP5 Tbio Non-IDG -0.80629 5.44 87
Centrosome-associated protein CEP250 CEP250 Tbio Non-IDG -0.66723 5.22 14
Gamma-tubulin complex component 6 TUBGCP6 Tbio Non-IDG -0.69093 4.86 78
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.73539 525.6 142
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.27308 14.5 115