Development Level

Tbio 108 | 10,625
Tchem 46 | 1,890
Tdark 16 | 7,003
Tclin 8 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 6 | 187
decreased body weight 4 | 174
embryonic lethality prior to o... 4 | 148
abnormal head morphology 3 | 10
decreased bone mineral content 3 | 157
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
increased mean corpuscular vol... 3 | 91
abnormal cranium morphology 2 | 32
abnormal spleen morphology 2 | 36
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating total pr... 2 | 41
increased circulating alkaline... 2 | 119
increased mean corpuscular hem... 2 | 93
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal snout morphology 1 | 18
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
decreased basophil cell number 1 | 11
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
small testis 1 | 37
urinary bladder obstruction 1 | 2
vertebral fusion 1 | 23

Disease

ovarian cancer 125 | 8,484
osteosarcoma 88 | 7,933
psoriasis 82 | 6,685
lung cancer 69 | 4,466
medulloblastoma, large-cell 67 | 6,234
glioblastoma 66 | 5,572
malignant mesothelioma 53 | 3,162
Breast cancer 50 | 3,094
atypical teratoid / rhabdoid tumor 50 | 4,369
Cancer 48 | 2,346
Multiple myeloma 44 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
primitive neuroectodermal tumor 42 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
pediatric high grade glioma 38 | 2,712
non-small cell lung cancer 37 | 2,798
group 3 medulloblastoma 35 | 2,254
colon cancer 32 | 1,475
oligodendroglioma 32 | 2,849
lung adenocarcinoma 30 | 2,713
ependymoma 27 | 2,514
invasive ductal carcinoma 27 | 2,950
Pick disease 26 | 1,893
pancreatic cancer 25 | 2,300
sonic hedgehog group medulloblastoma 25 | 1,482
adrenocortical carcinoma 24 | 1,427
Waldenstrons macroglobulinemia 22 | 765
astrocytic glioma 22 | 2,241
ductal carcinoma in situ 22 | 1,745
pilocytic astrocytoma 22 | 3,086
Carcinoma 21 | 2,147
breast carcinoma 21 | 1,614
nasopharyngeal carcinoma 21 | 1,056
posterior fossa group A ependymoma 21 | 1,511
subependymal giant cell astrocytoma 21 | 2,287
dermatomyositis 20 | 933
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
HIV Infections 18 | 100
astrocytoma 17 | 1,493
ulcerative colitis 17 | 2,087
tuberculosis 16 | 1,557
Intellectual disability 15 | 573
diabetes mellitus 15 | 1,663
interstitial cystitis 15 | 2,299
Atopic dermatitis 14 | 944
Endometriosis 14 | 535
Microcephaly 14 | 149
posterior fossa group B ependymoma 14 | 1,530
adult high grade glioma 13 | 2,148
atypical teratoid/rhabdoid tumor 13 | 1,095
juvenile dermatomyositis 13 | 1,189
non primary Sjogren syndrome sicca 13 | 840
IGA Glomerulonephritis 11 | 454
Rheumatoid Arthritis 11 | 1,160
acute myeloid leukemia 11 | 780
esophageal adenocarcinoma 11 | 737
medulloblastoma 11 | 1,524
tuberculosis and treatment for 6 months 11 | 686
Obesity 10 | 616
acute quadriplegic myopathy 10 | 1,157
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 789
progressive supranuclear palsy 10 | 674
Mammary Neoplasms 9 | 410
group 4 medulloblastoma 9 | 1,875
Peripheral Neuropathy 8 | 303
cutaneous lupus erythematosus 8 | 1,056
primary pancreatic ductal adenocarcinoma 8 | 1,271
Neurodegenerative disease 7 | 383
Schizophrenia 7 | 501
lung carcinoma 7 | 2,844
pancreatic carcinoma 7 | 567
Amyotrophic Lateral Sclerosis 6 | 431
Duchenne muscular dystrophy 6 | 602
Joubert syndrome 6 | 61
Melanoma 6 | 261
Seckel syndrome 6 | 34
Squamous cell carcinoma of esophagus 6 | 82
spina bifida 6 | 1,064
Bardet-Biedl Syndrome 5 | 40
Lissencephaly 5 | 61
Mantle cell lymphoma 5 | 18
Nephronophthisis 5 | 74
Neuroblastoma 5 | 78
Polycystic Ovary Syndrome 5 | 332
active Crohn's disease 5 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
chronic rhinosinusitis 5 | 512
gastric cancer 5 | 430
gastric carcinoma 5 | 832
hepatocellular carcinoma 5 | 532
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
Crohn's disease 4 | 304
Miller-Dieker lissencephaly syndrome 4 | 20
Myocardial Ischemia 4 | 169
Prostatic Neoplasms 4 | 471
Senior-Loken syndrome 4 | 21
aldosterone-producing adenoma 4 | 664

Tissue

Blood and immune system 178 | 17,995
Endocrine System 178 | 18,512
Female tissues 178 | 18,647
Male tissues 178 | 17,969
Nervous System 178 | 18,561
Cardiovascular System 177 | 17,958
Digestive Tract 177 | 18,473
Liver and Pancreas 177 | 18,136
Urinary Tract 177 | 18,444
Respiratory system 175 | 17,484
Skin and soft tissues 175 | 18,115

Target Family

Non-IDG 99 | 11,971
Enzyme 59 | 4,146
Kinase 14 | 634
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Mitotic G2-G2/M phases 178 | 178
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -1.97186 101.3 125
Centrosomal protein of 152 kDa CEP152 Tbio Non-IDG -1.23739 18.0 90
Alpha-centractin ACTR1A Tbio Non-IDG -0.72323 6.08 149
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.29353 14.5 115
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150