Development Level

Tbio 131 | 11,445
Tchem 30 | 1,598
Tdark 15 | 6,588
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
decreased circulating choleste... 4 | 93
decreased total body fat amoun... 4 | 207
male infertility 4 | 123
abnormal head morphology 3 | 10
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating total pr... 3 | 49
decreased lean body mass 3 | 135
increased mean corpuscular vol... 3 | 92
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal spleen morphology 2 | 55
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
decreased circulating serum al... 2 | 82
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased cardiac muscle contr... 1 | 8
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
sclerocornea 1 | 2
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

ovarian cancer 127 | 8,520
Carcinoma 110 | 11,493
osteosarcoma 89 | 7,950
psoriasis 82 | 6,694
lung cancer 73 | 4,740
glioblastoma 70 | 5,792
medulloblastoma, large-cell 66 | 6,241
atypical teratoid / rhabdoid tumor 63 | 5,112
group 3 medulloblastoma 62 | 4,104
Breast cancer 57 | 3,578
malignant mesothelioma 55 | 3,232
ependymoma 51 | 4,679
Cancer 48 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
adult high grade glioma 46 | 3,801
Multiple myeloma 45 | 1,332
primitive neuroectodermal tumor 43 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
non-small cell lung cancer 38 | 2,890
oligodendroglioma 33 | 2,850
colon cancer 32 | 1,478
lung adenocarcinoma 30 | 2,716
Kidney cancer 29 | 2,613
invasive ductal carcinoma 27 | 2,951
Pick disease 26 | 1,894
Astrocytoma, Pilocytic 24 | 3,081
adrenocortical carcinoma 24 | 1,428
astrocytic glioma 24 | 2,597
pancreatic cancer 24 | 2,398
Waldenstrons macroglobulinemia 23 | 765
subependymal giant cell astrocytoma 23 | 2,287
breast carcinoma 22 | 1,638
ductal carcinoma in situ 22 | 1,745
Intellectual disability 21 | 1,016
dermatomyositis 21 | 966
nasopharyngeal carcinoma 21 | 1,058
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
tuberculosis 19 | 2,010
HIV Infections 18 | 102
astrocytoma 18 | 1,146
diabetes mellitus 17 | 1,728
Microcephaly 16 | 166
ulcerative colitis 16 | 1,819
Atopic dermatitis 15 | 952
Autosomal recessive predisposition 15 | 1,442
Cognitive delay 15 | 608
Endometriosis 15 | 540
Global developmental delay 15 | 608
Mental and motor retardation 15 | 608
interstitial cystitis 15 | 2,312
Schizophrenia 13 | 1,160
Short stature 13 | 531
Small head 13 | 374
juvenile dermatomyositis 13 | 1,187
non primary Sjogren syndrome sicca 13 | 891
Dull intelligence 12 | 645
Epilepsy 12 | 792
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Seizures 12 | 596
acute myeloid leukemia 11 | 783
esophageal adenocarcinoma 11 | 737
Breast Neoplasms 10 | 445
Rheumatoid arthritis 10 | 1,191
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 735
progressive supranuclear palsy 10 | 676
Downward slant of palpebral fissure 9 | 158
Glaucoma 9 | 239
Liver Cirrhosis, Experimental 9 | 769
Mammary Neoplasms 9 | 425
acute quadriplegic myopathy 9 | 1,158
group 4 medulloblastoma 9 | 1,855
tuberculosis and treatment for 6 months 9 | 409
Joubert syndrome 8 | 66
Obesity 8 | 678
cutaneous lupus erythematosus 8 | 1,057
lung carcinoma 8 | 2,843
Agenesis of corpus callosum 7 | 83
Cataract 7 | 297
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Muscle hypotonia 7 | 571
Neurodegenerative disease 7 | 414
medulloblastoma 7 | 720
pediatric high grade glioma 7 | 1,064
primary pancreatic ductal adenocarcinoma 7 | 1,109
Anteverted nostril 6 | 191
Bipolar Disorder 6 | 666
Broad flat nasal bridge 6 | 236
Duchenne muscular dystrophy 6 | 601
Lens Opacities 6 | 231
Low set ears 6 | 181
Sloping forehead 6 | 46
hepatocellular carcinoma 6 | 547
spina bifida 6 | 1,074

Tissue

Endocrine System 182 | 18,159
Blood and immune system 181 | 16,909
Digestive Tract 181 | 17,369
Female tissues 181 | 17,400
Male tissues 181 | 17,142
Nervous System 181 | 16,725
Respiratory system 181 | 16,393
Urinary Tract 181 | 16,678
Cardiovascular System 180 | 15,192
Liver and Pancreas 180 | 16,750
Skin and soft tissues 180 | 17,230

Target Family

Non-IDG 102 | 12,091
Enzyme 62 | 4,145
Kinase 14 | 634
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Mitotic G2-G2/M phases 184 | 184
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Mitotic-spindle organizing protein 2A MZT2A Tdark Non-IDG 0.60 0.13 2
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -2.03755 107.9 152