Development Level

Tbio 104 | 11,651
Tchem 24 | 1,388
Tclin 17 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 9 | 278
abnormal embryo size 5 | 220
preweaning lethality, incomple... 5 | 499
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased lymphocyte cell numb... 3 | 83
increased neutrophil cell numb... 3 | 46
male infertility 3 | 123
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased vertical activity 2 | 208
edema 2 | 59
female infertility 2 | 60
increased circulating choleste... 2 | 66
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 109 | 8,520
lung cancer 78 | 4,740
Carcinoma 77 | 11,493
Cancer 73 | 2,499
glioblastoma 72 | 5,792
psoriasis 72 | 6,694
osteosarcoma 70 | 7,950
medulloblastoma, large-cell 66 | 6,241
group 3 medulloblastoma 61 | 4,104
Breast cancer 58 | 3,578
atypical teratoid / rhabdoid tumor 53 | 5,112
malignant mesothelioma 53 | 3,232
non-small cell lung cancer 50 | 2,890
primitive neuroectodermal tumor 43 | 3,035
Multiple myeloma 42 | 1,332
adult high grade glioma 40 | 3,801
adrenocortical carcinoma 39 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
lung adenocarcinoma 39 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
invasive ductal carcinoma 36 | 2,951
ependymoma 34 | 4,679
nasopharyngeal carcinoma 30 | 1,058
ductal carcinoma in situ 29 | 1,745
oligodendroglioma 28 | 2,850
colon cancer 26 | 1,478
Astrocytoma, Pilocytic 25 | 3,081
Waldenstrons macroglobulinemia 25 | 765
astrocytoma 25 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
pancreatic cancer 22 | 2,398
subependymal giant cell astrocytoma 21 | 2,287
Atopic dermatitis 20 | 952
Endometriosis 20 | 540
breast carcinoma 20 | 1,638
primary Sjogren syndrome 20 | 735
tuberculosis 20 | 2,010
dermatomyositis 19 | 966
HIV Infections 16 | 102
astrocytic glioma 15 | 2,597
diabetes mellitus 14 | 1,728
interstitial cystitis 14 | 2,312
ulcerative colitis 14 | 1,819
Autosomal recessive predisposition 13 | 1,442
Kidney cancer 13 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
pituitary cancer 13 | 1,972
Breast Neoplasms 12 | 445
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
Mammary Neoplasms 12 | 425
lung carcinoma 12 | 2,843
pediatric high grade glioma 12 | 1,064
Lung Neoplasms 11 | 232
Stomach Neoplasms 11 | 300
cystic fibrosis 11 | 1,696
esophageal adenocarcinoma 11 | 737
non primary Sjogren syndrome sicca 11 | 891
Intellectual disability 10 | 1,016
Liver Cirrhosis, Experimental 10 | 769
Pick disease 10 | 1,894
acute myeloid leukemia 10 | 783
juvenile dermatomyositis 10 | 1,187
Anemia 9 | 365
Prostatic Neoplasms 9 | 495
Rheumatoid arthritis 9 | 1,191
cutaneous lupus erythematosus 9 | 1,057
group 4 medulloblastoma 9 | 1,855
Cognitive delay 8 | 608
Colonic Neoplasms 8 | 142
Colorectal Neoplasms 8 | 243
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Low intelligence 8 | 645
Meier-Gorlin syndrome 8 | 10
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Ovarian Neoplasms 8 | 102
Polycystic ovary syndrome 8 | 360
Poor school performance 8 | 645
Small head 8 | 374
active Crohn's disease 8 | 922
ovarian neoplasm 8 | 99
Adenoma 7 | 167
Bladder Neoplasm 7 | 112
Carcinoma, Squamous Cell 7 | 110
Diarrhea 7 | 253
Epilepsy 7 | 792
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Mammary Neoplasms, Experimental 7 | 154
Seizures 7 | 596
Urinary Bladder Neoplasms 7 | 114
Vascular disease 7 | 319
acute quadriplegic myopathy 7 | 1,158
medulloblastoma 7 | 720
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Blood and immune system 147 | 16,909
Digestive Tract 147 | 17,369
Endocrine System 147 | 18,159
Female tissues 147 | 17,400
Liver and Pancreas 147 | 16,750
Male tissues 147 | 17,142
Nervous System 147 | 16,725
Respiratory system 147 | 16,393
Skin and soft tissues 147 | 17,230
Urinary Tract 147 | 16,678
Cardiovascular System 144 | 15,192

Target Family

Enzyme 68 | 4,145
Non-IDG 53 | 12,091
Kinase 16 | 634
Transcription Factor 11 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Mitotic G1-G1/S phases 149 | 149
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
F-box only protein 5 FBXO5 Tbio Non-IDG -1.71993 56.0 137
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110