Development Level

Tbio 85 | 10,625
Tchem 39 | 1,890
Tclin 14 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
embryonic lethality prior to o... 7 | 148
embryonic lethality prior to t... 5 | 187
abnormal lens morphology 2 | 73
cataract 2 | 26
decreased body length 2 | 108
male infertility 2 | 62
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
thrombocytosis 1 | 23
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 105 | 8,484
lung cancer 73 | 4,466
psoriasis 70 | 6,685
glioblastoma 68 | 5,572
osteosarcoma 67 | 7,933
Cancer 66 | 2,346
medulloblastoma, large-cell 64 | 6,234
Breast cancer 50 | 3,094
malignant mesothelioma 50 | 3,162
non-small cell lung cancer 47 | 2,798
primitive neuroectodermal tumor 44 | 3,031
Multiple myeloma 41 | 1,327
pediatric high grade glioma 40 | 2,712
atypical teratoid / rhabdoid tumor 39 | 4,369
group 3 medulloblastoma 39 | 2,254
adrenocortical carcinoma 37 | 1,427
lung adenocarcinoma 37 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
invasive ductal carcinoma 36 | 2,950
nasopharyngeal carcinoma 29 | 1,056
ductal carcinoma in situ 28 | 1,745
oligodendroglioma 27 | 2,849
colon cancer 25 | 1,475
pilocytic astrocytoma 25 | 3,086
astrocytoma 24 | 1,493
Waldenstrons macroglobulinemia 23 | 765
posterior fossa group A ependymoma 22 | 1,511
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
pancreatic cancer 21 | 2,300
subependymal giant cell astrocytoma 20 | 2,287
Atopic dermatitis 19 | 944
Endometriosis 18 | 535
breast carcinoma 18 | 1,614
dermatomyositis 18 | 933
primary Sjogren syndrome 17 | 789
atypical teratoid/rhabdoid tumor 16 | 1,095
ependymoma 16 | 2,514
HIV Infections 15 | 100
medulloblastoma 14 | 1,524
sonic hedgehog group medulloblastoma 14 | 1,482
ulcerative colitis 14 | 2,087
astrocytic glioma 13 | 2,241
pituitary cancer 13 | 1,972
diabetes mellitus 12 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
tuberculosis 12 | 1,557
Liver carcinoma 11 | 217
Mammary Neoplasms 11 | 410
adult high grade glioma 11 | 2,148
interstitial cystitis 11 | 2,299
lung carcinoma 11 | 2,844
non primary Sjogren syndrome sicca 11 | 840
IGA Glomerulonephritis 10 | 454
Lung Neoplasms 10 | 171
esophageal adenocarcinoma 10 | 737
Carcinoma 9 | 2,147
Pick disease 9 | 1,893
Stomach Neoplasms 9 | 282
acute myeloid leukemia 9 | 780
cystic fibrosis 9 | 1,665
juvenile dermatomyositis 9 | 1,189
tuberculosis and treatment for 6 months 9 | 686
Adenoma 8 | 165
Prostatic Neoplasms 8 | 471
Rheumatoid Arthritis 8 | 1,160
cutaneous lupus erythematosus 8 | 1,056
group 4 medulloblastoma 8 | 1,875
ovarian neoplasm 8 | 97
Colonic Neoplasms 7 | 126
Mammary Neoplasms, Experimental 7 | 150
Meier-Gorlin syndrome 7 | 12
active Crohn's disease 7 | 918
acute quadriplegic myopathy 7 | 1,157
primary pancreatic ductal adenocarcinoma 7 | 1,271
Animal Mammary Neoplasms 6 | 136
Bladder Neoplasm 6 | 109
Colorectal Neoplasms 6 | 217
Microcephaly 6 | 149
Peripheral Neuropathy 6 | 303
Polycystic Ovary Syndrome 6 | 332
Seckel syndrome 6 | 34
Squamous cell carcinoma of esophagus 6 | 82
gastric cancer 6 | 430
inflammatory breast cancer 6 | 404
Acute lymphoid leukemia 5 | 25
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Mantle cell lymphoma 5 | 18
Melanoma 5 | 261
Metastatic Breast Carcinoma 5 | 21
Vascular disease 5 | 281
chronic rhinosinusitis 5 | 512
pancreatic carcinoma 5 | 567
Alzheimer's disease 4 | 644
Myocardial Ischemia 4 | 169
fibroadenoma 4 | 557
hepatocellular carcinoma 4 | 532
non-small cell lung carcinoma 4 | 413
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 3 months 4 | 327

Tissue

Endocrine System 142 | 18,512
Blood and immune system 141 | 17,995
Cardiovascular System 141 | 17,958
Digestive Tract 141 | 18,473
Female tissues 141 | 18,647
Liver and Pancreas 141 | 18,136
Male tissues 141 | 17,969
Nervous System 141 | 18,561
Respiratory system 141 | 17,484
Urinary Tract 141 | 18,444
Skin and soft tissues 140 | 18,115

Target Family

Enzyme 68 | 4,146
Non-IDG 50 | 11,971
Kinase 13 | 634
Transcription Factor 10 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Mitotic G1-G1/S phases 142 | 142
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.29353 14.5 115
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.81595 662.3 551
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.88736 79.3 89
Cyclin-dependent kinase inhibitor 1C CDKN1C Tbio Enzyme -2.77104 600.5 488