Development Level

Tdark 62 | 7,003
Tbio 26 | 10,625
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
decreased circulating glucose ... 2 | 121
embryonic growth retardation 2 | 28
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
decreased CD11b-low dendritic ... 1 | 3
decreased grip strength 1 | 123
increased CD11b-high dendritic... 1 | 5
increased circulating creatini... 1 | 29
increased grip strength 1 | 83
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 60 | 8,492
osteosarcoma 30 | 7,933
lung cancer 27 | 4,473
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
psoriasis 17 | 6,685
Multiple myeloma 16 | 1,328
non primary Sjogren syndrome sicca 16 | 840
Breast cancer 15 | 3,099
acute myeloid leukemia 12 | 785
glioblastoma 12 | 5,572
medulloblastoma, large-cell 12 | 6,234
non-small cell lung cancer 11 | 2,798
astrocytic glioma 9 | 2,241
atypical teratoid / rhabdoid tumor 9 | 4,369
group 3 medulloblastoma 9 | 2,254
Mammary Neoplasms 8 | 410
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
malignant mesothelioma 6 | 3,163
pediatric high grade glioma 6 | 2,712
adult high grade glioma 5 | 2,148
breast carcinoma 5 | 1,614
colon cancer 5 | 1,475
invasive ductal carcinoma 5 | 2,950
lung adenocarcinoma 5 | 2,714
Brain glioma 4 | 10
diabetes mellitus 4 | 1,663
Disease Progression 3 | 125
Pick disease 3 | 1,893
Stomach Neoplasms 3 | 282
Waldenstrons macroglobulinemia 3 | 765
cystic fibrosis 3 | 1,670
dermatomyositis 3 | 967
ependymoma 3 | 2,514
lung carcinoma 3 | 2,844
nasopharyngeal carcinoma 3 | 1,056
oligodendroglioma 3 | 2,849
sonic hedgehog group medulloblastoma 3 | 1,482
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 267
Combined oxidative phosphorylation deficiency 2 | 8
Down syndrome 2 | 548
Muscle Weakness 2 | 92
Nonsyndromic deafness 2 | 121
Pseudoxanthoma elasticum 2 | 19
active Crohn's disease 2 | 918
gastric cancer 2 | 436
hepatocellular carcinoma 2 | 550
medulloblastoma 2 | 1,524
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
primitive neuroectodermal tumor 2 | 3,031
Alcohol dependence 1 | 107
Allergic rhinitis 1 | 92
Angiolipoma 1 | 3
Ankylosing spondylitis 1 | 138
Campylobacteriosis 1 | 12
Cancer 1 | 2,346
Cardiovascular system disease 1 | 194
Coronary artery disease 1 | 240
Deafness 1 | 18
DiGeorge syndrome 1 | 46
Diarrhea 1 | 155
Dyslexia 1 | 36
Enamel caries 1 | 8
Epilepsy 1 | 346
Focal epithelial hyperplasia 1 | 4
Gastroenteritis 1 | 46
Gastroparesis 1 | 20
Gaucher disease type 1 1 | 171
Gilles de la Tourette syndrome 1 | 47
Hodgkin's lymphoma, nodular sclerosis 1 | 24
Kearns-Sayre syndrome 1 | 6
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 1 | 14
Leigh disease 1 | 81
Melanoma 1 | 261
Migraine Disorders 1 | 26
Mitochondrial complex I deficiency 1 | 37
Myopathy 1 | 128
Osteoarthritis 1 | 96
Osteoporosis 1 | 259
Parkinson's disease 1 | 364
Sensorineural hearing loss 1 | 107
Specific language impairment 1 | 31
Squamous cell carcinoma 1 | 96
Thrombophilia 1 | 37
Velocardiofacial syndrome 1 | 45
active ulcerative colitis 1 | 477
acute quadriplegic myopathy 1 | 1,157
adrenocortical carcinoma 1 | 1,427
aldosterone-producing adenoma 1 | 664
atypical teratoid/rhabdoid tumor 1 | 1,095
esophageal adenocarcinoma 1 | 737
hereditary spastic paraplegia 1 | 313
inflammatory breast cancer 1 | 404
interstitial lung disease 1 | 292
progressive supranuclear palsy 1 | 674
tuberculosis 1 | 1,563
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 87 | 17,995
Cardiovascular System 87 | 17,958
Digestive Tract 87 | 18,473
Endocrine System 87 | 18,512
Female tissues 87 | 18,647
Liver and Pancreas 87 | 18,136
Male tissues 87 | 17,969
Nervous System 87 | 18,561
Respiratory system 87 | 17,484
Urinary Tract 87 | 18,444
Skin and soft tissues 85 | 18,115

Target Family

Non-IDG 84 | 11,969
Enzyme 5 | 4,146

Reactome Pathway

Mitochondrial translation init... 89 | 89
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
39S ribosomal protein L43, mitochondrial MRPL43 Tdark Non-IDG -0.23709 1.39 24
28S ribosomal protein S7, mitochondrial MRPS7 Tdark Non-IDG -2.74950 523.2 47
28S ribosomal protein S17, mitochondrial MRPS17 Tbio Non-IDG 0.44 0.00000 22
39S ribosomal protein L52, mitochondrial MRPL52 Tdark Non-IDG 1.14 0.07 38
28S ribosomal protein S28, mitochondrial MRPS28 Tdark Non-IDG 0.00000 1.00 43
39S ribosomal protein L49, mitochondrial MRPL49 Tbio Non-IDG -2.70795 488.4 64
28S ribosomal protein S23, mitochondrial MRPS23 Tdark Non-IDG -0.00769 0.46 90
28S ribosomal protein S18c, mitochondrial MRPS18C Tdark Non-IDG 0.18 0.25 55
28S ribosomal protein S16, mitochondrial MRPS16 Tbio Non-IDG -0.16137 1.49 53
39S ribosomal protein L11, mitochondrial MRPL11 Tdark Non-IDG -0.63555 3.41 156