Development Level

Tdark 59 | 6,593
Tbio 30 | 11,651

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
embryonic growth retardation 4 | 106
abnormal bone structure 2 | 187
decreased circulating glucose ... 2 | 126
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
decreased circulating sodium l... 1 | 22
impaired pupillary reflex 1 | 26
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 58 | 8,520
osteosarcoma 32 | 7,950
lung cancer 28 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
Carcinoma 19 | 11,493
non primary Sjogren syndrome sicca 17 | 891
psoriasis 17 | 6,694
Breast cancer 15 | 3,578
Multiple myeloma 15 | 1,332
acute myeloid leukemia 12 | 783
glioblastoma 12 | 5,792
group 3 medulloblastoma 12 | 4,104
medulloblastoma, large-cell 12 | 6,241
non-small cell lung cancer 12 | 2,890
atypical teratoid / rhabdoid tumor 9 | 5,112
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
adult high grade glioma 7 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
ependymoma 6 | 4,679
malignant mesothelioma 6 | 3,232
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
pediatric high grade glioma 5 | 1,064
Autosomal recessive predisposition 4 | 1,442
Brain glioma 4 | 7
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
nasopharyngeal carcinoma 4 | 1,058
Acidosis, Lactic 3 | 97
Combined oxidative phosphorylation deficiency 3 | 14
Disease Progression 3 | 136
Hepatomegaly 3 | 285
Increased serum lactate 3 | 60
Lactic acidemia 3 | 95
Leigh disease 3 | 100
Pick disease 3 | 1,894
Stomach Neoplasms 3 | 300
Waldenstrons macroglobulinemia 3 | 765
cystic fibrosis 3 | 1,696
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287
Adenocarcinoma of lung 2 | 142
Cerebellar Ataxia 2 | 304
Cognitive delay 2 | 608
Dilated ventricles (finding) 2 | 121
Disease Models, Animal 2 | 155
Elevated hepatic transaminases 2 | 81
Epilepsy 2 | 792
Feeding difficulties in infancy 2 | 175
Global developmental delay 2 | 608
Hepatic enzyme increased 2 | 81
Impaired cognition 2 | 96
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Mental and motor retardation 2 | 608
Mental impairment 2 | 95
Neonatal Hypotonia 2 | 64
Nonsyndromic deafness 2 | 142
Optic Atrophy 2 | 242
Patent ductus arteriosus 2 | 90
Pseudoxanthoma elasticum 2 | 18
Retinitis pigmentosa 4 2 | 38
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
active Crohn's disease 2 | 922
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
primitive neuroectodermal tumor 2 | 3,035
tuberculosis and treatment for 6 months 2 | 409
Ankylosing spondylitis 1 | 140
Brachydactyly 1 | 156
Candidiasis 1 | 55
Epilepsies, Myoclonic 1 | 32
Esophageal Neoplasms 1 | 69
Gaucher disease type 1 1 | 180
Generalized myoclonic seizures 1 | 30
Hodgkin's lymphoma, nodular sclerosis 1 | 22
Lateral medullary syndrome 1 | 4
Lethargy 1 | 77
Lipoma 1 | 32
MYELODYSPLASTIC SYNDROME 1 | 53
Muscle Weakness 1 | 170
Myoclonic Epilepsies, Progressive 1 | 44
Squamous cell carcinoma 1 | 129
Thrombophilia 1 | 38
Tinnitus 1 | 19
Wilson-Turner syndrome 1 | 14
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298

Tissue

Blood and immune system 85 | 16,909
Cardiovascular System 85 | 15,192
Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Female tissues 85 | 17,400
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678

Target Family

Non-IDG 86 | 12,091
Enzyme 3 | 4,145

Reactome Pathway

Mitochondrial translation elon... 89 | 89
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
39S ribosomal protein L42, mitochondrial MRPL42 Tdark Non-IDG 0.02 0.40 139
28S ribosomal protein S18b, mitochondrial MRPS18B Tdark Non-IDG -0.67793 4.10 45
39S ribosomal protein S18a, mitochondrial MRPS18A Tdark Non-IDG 0.32 0.72 57
39S ribosomal protein L16, mitochondrial MRPL16 Tdark Non-IDG -0.22185 1.67 71
39S ribosomal protein L35, mitochondrial MRPL35 Tdark Non-IDG 0.85 0.29 21
28S ribosomal protein S29, mitochondrial DAP3 Tbio Non-IDG -1.22289 22.6 312
39S ribosomal protein L39, mitochondrial MRPL39 Tdark Non-IDG -0.45335 2.81 146
Humanin MT-RNR2 Tdark Non-IDG 0.00000 0