Development Level

Tbio 49 | 10,625
Tdark 11 | 7,003
Tchem 2 | 1,890

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
decreased body weight 3 | 174
decreased bone mineral content 2 | 157
increased blood urea nitrogen ... 2 | 44
increased circulating phosphat... 2 | 24
increased heart weight 2 | 37
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal retinal outer nuclear... 1 | 5
decreased IgM level 1 | 1
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased exploration in new e... 1 | 56
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 35 | 8,484
lung cancer 24 | 4,466
osteosarcoma 19 | 7,933
Multiple myeloma 13 | 1,327
medulloblastoma, large-cell 13 | 6,234
psoriasis 13 | 6,685
astrocytic glioma 11 | 2,241
atypical teratoid / rhabdoid tumor 11 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
glioblastoma 10 | 5,572
Breast cancer 9 | 3,094
ependymoma 9 | 2,514
Deafness dystonia syndrome 7 | 20
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
malignant mesothelioma 7 | 3,162
Barth syndrome 6 | 23
Neurodegenerative disease 6 | 383
adult high grade glioma 6 | 2,148
lung adenocarcinoma 6 | 2,713
non-small cell lung cancer 6 | 2,798
Cardiomyopathy 5 | 110
Dystonia 5 | 77
invasive ductal carcinoma 5 | 2,950
non primary Sjogren syndrome sicca 5 | 840
oligodendroglioma 5 | 2,849
primitive neuroectodermal tumor 5 | 3,031
3-methylglutaconic aciduria 4 | 29
Cancer 4 | 2,346
Parkinson's disease 4 | 364
Rheumatoid Arthritis 4 | 1,160
Waldenstrons macroglobulinemia 4 | 765
diabetes mellitus 4 | 1,663
group 4 medulloblastoma 4 | 1,875
medulloblastoma 4 | 1,524
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 644
Endotoxemia 3 | 8
HIV Infections 3 | 100
Leigh disease 3 | 81
Liver disease 3 | 219
Neuropathy 3 | 210
Spotted fever 3 | 7
acute myeloid leukemia 3 | 780
breast carcinoma 3 | 1,614
group 3 medulloblastoma 3 | 2,254
pediatric high grade glioma 3 | 2,712
Acute kidney injury 2 | 65
Amyotrophic Lateral Sclerosis 2 | 431
Anoxia 2 | 33
Cardiomyopathies 2 | 90
Cerebellar Ataxia 2 | 72
Cholestasis 2 | 93
Cortical blindness 2 | 15
Dilated cardiomyopathy 2 | 50
Friedreich ataxia 2 | 23
Lactic acidosis 2 | 42
Liver carcinoma 2 | 217
Melioidosis 2 | 11
Menkes disease 2 | 20
Myopathy 2 | 128
Non-alcoholic Fatty Liver Disease 2 | 40
Pick disease 2 | 1,893
Renal Cell Carcinoma 2 | 199
Sengers syndrome 2 | 17
Sideroblastic anemia 2 | 18
Sleeping sickness 2 | 37
acute quadriplegic myopathy 2 | 1,157
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,665
dermatomyositis 2 | 933
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 832
hereditary spastic paraplegia 2 | 313
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung carcinoma 2 | 2,844
pilocytic astrocytoma 2 | 3,086
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,557
ulcerative colitis 2 | 2,087
Acute coronary syndrome 1 | 37
Allergic conjunctivitis 1 | 25
Angioedema 1 | 36
Appendiceal neoplasm 1 | 3
Ataxia telangiectasia 1 | 31
Babesiosis 1 | 13
Chlamydia 1 | 18
Congenital bile acid synthesis defect 1 | 13
Cryptogenic organizing pneumonia 1 | 3
Ehrlichiosis 1 | 9
Kufor-Rakeb syndrome 1 | 6
Optic atrophy 1 | 43
Pasteurellosis 1 | 12
Respiratory failure 1 | 30
Sedation 1 | 11
Spindle cell hemangioma 1 | 16
Spinocerebellar ataxia type 12 1 | 4
Uveitis 1 | 103

Tissue

Blood and immune system 62 | 17,995
Cardiovascular System 62 | 17,958
Digestive Tract 62 | 18,473
Endocrine System 62 | 18,512
Female tissues 62 | 18,647
Liver and Pancreas 62 | 18,136
Male tissues 62 | 17,969
Nervous System 62 | 18,561
Respiratory system 62 | 17,484
Urinary Tract 62 | 18,444
Skin and soft tissues 61 | 18,115

Target Family

Enzyme 31 | 4,146
Non-IDG 27 | 11,971
Transporter 4 | 473

Reactome Pathway

Mitochondrial protein import 62 | 62
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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