Development Level

Tbio 11 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased mean corpuscular hem... 1 | 96

Disease

Friedreich ataxia 8 | 24
ovarian cancer 7 | 8,520
osteosarcoma 6 | 7,950
medulloblastoma, large-cell 5 | 6,241
Breast cancer 4 | 3,578
Sideroblastic anemia 4 | 20
lung cancer 4 | 4,740
Autosomal recessive predisposition 3 | 1,442
atypical teratoid / rhabdoid tumor 3 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Anemia 2 | 365
Carcinoma 2 | 11,493
Muscle Weakness 2 | 170
Myoglobinuria 2 | 15
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
malignant mesothelioma 2 | 3,232
Abnormal iron deposition in mitochondria 1 | 1
Abnormal visual evoked potential 1 | 26
Acidosis, Lactic 1 | 97
Action Tremor 1 | 22
Ampulla of Vater carcinoma 1 | 2
Anemia, Sideroblastic 1 | 7
Areflexia of lower limbs 1 | 9
Ataxia, Appendicular 1 | 25
Babinski Reflex 1 | 100
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19 1 | 1
Cardiomyopathies 1 | 110
Cardiomyopathy 1 | 116
Cerebellar Dysmetria 1 | 56
Combined oxidative phosphorylation deficiency 1 | 14
Congenital adrenal hyperplasia 1 | 73
Congenital adrenal insufficiency 1 | 7
Congenital bile acid synthesis defect 1 | 15
Congenital pes cavus 1 | 88
Congestive heart failure 1 | 113
Creatine phosphokinase serum increased 1 | 110
Decreased activity of mitochondrial complex II 1 | 3
Decreased amplitude of sensory action potentials 1 | 2
Decreased mitochondrial complex I activity 1 | 2
Decreased mitochondrial complex III activity 1 | 2
Decreased sensory nerve conduction velocities (NCV) 1 | 8
Decreased vibratory sense 1 | 7
Dysarthria 1 | 192
Dyspnea 1 | 76
Electrocardiogram abnormal 1 | 81
Elevated creatine kinase 1 | 110
Erythropoietic protoporphyria 1 | 15
Gait Ataxia 1 | 51
Gait imbalance 1 | 17
Glycine encephalopathy 1 | 29
Heart failure 1 | 162
Hemoglobin low 1 | 124
Hyperferritinaemia 1 | 14
Hypertrophic Cardiomyopathy 1 | 117
Hypochromic anemia 1 | 9
Impaired exercise tolerance 1 | 42
Increased ferritin 1 | 14
Increased intramyocellular lipid droplets 1 | 13
Increased serum lactate 1 | 60
Infantile onset 1 | 238
Intrahepatic cholestasis 1 | 20
Iron metabolism disease 1 | 20
Lactic acidemia 1 | 95
Lactic acidosis 1 | 51
Leukodystrophy 1 | 55
MYOPATHY WITH EXERCISE INTOLERANCE, SWEDISH TYPE 1 | 1
Mitochondrial Myopathies 1 | 21
Mitochondrial complex I deficiency 1 | 46
Mitochondrial myopathy 1 | 26
Multiple Mitochondrial Dysfunctions Syndrome 1 | 3
Muscle Cramp 1 | 55
Myopathy 1 | 185
Myopathy with lactic acidosis, hereditary 1 | 1
Neuropathy 1 | 261
Palpitations 1 | 18
Pearson syndrome 1 | 19
Peripheral sensory axonal neuropathy 1 | 7
Proliferative diabetic retinopathy 1 | 4
Respiratory complex I deficiency 1 | 2
Respiratory complex II deficiency 1 | 3
Respiratory complex III deficiency 1 | 2
Scoliosis 1 | 44
Sensory axonal neuropathy 1 | 7
Sensory neuropathy 1 | 20
Serum ferritin increased 1 | 14
Spastic Ataxia 1 | 18
Sphincter disturbances 1 | 16
Spotted fever 1 | 8
Subsarcolemmal accumulations of abnormally shaped mitochondria 1 | 4
Terminal tremor 1 | 20
Visual field defects 1 | 19
alcohol-related neurodevelopmental disorder 1 | 13
dentatorubral-pallidoluysian atrophy 1 | 21
infantile cerebellar-retinal degeneration 1 | 3
inflammatory breast cancer 1 | 286
locked-in syndrome 1 | 14
posterior fossa group B ependymoma 1 | 416

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 2 | 4,145
Transporter 2 | 473

Reactome Pathway

Mitochondrial iron-sulfur clus... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
LYR motif-containing protein 4 LYRM4 Tbio Non-IDG -1.25062 16.6 69
Iron-sulfur cluster assembly 1 homolog, mitochondrial ISCA1 Tbio Non-IDG -1.68100 45.7 44
Cysteine desulfurase, mitochondrial NFS1 Tbio Enzyme -1.70267 46.3 131
Mitoferrin-1 SLC25A37 Tbio Transporter -1.58954 37.6 97
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial HSCB Tbio Non-IDG -1.63830 47.3 42
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.85150 6.83 4
Mitoferrin-2 SLC25A28 Tbio Transporter -1.06193 10.8 111
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial ISCU Tbio Non-IDG -2.25839 167.3 167
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
Glutaredoxin-related protein 5, mitochondrial GLRX5 Tbio Non-IDG -1.86742 74.9 111