Development Level

Tbio 17 | 11,445
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal sleep behavior 2 | 70
impaired righting response 2 | 26
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal coat appearance 1 | 31
abnormal sensory capabilities-... 1 | 8
absent vibrissae 1 | 12
decreased cardiac stroke volum... 1 | 6
decreased circulating glucose ... 1 | 126
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
enlarged testis 1 | 6
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10

Disease

ovarian cancer 15 | 8,520
Carcinoma 13 | 11,493
osteosarcoma 9 | 7,950
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
psoriasis 6 | 6,694
Multiple myeloma 5 | 1,332
glioblastoma 5 | 5,792
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
Acquired scoliosis 3 | 281
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Cerebellar Ataxia 3 | 304
Curvature of spine 3 | 282
Epilepsy 3 | 792
Nystagmus 3 | 317
Optic Atrophy 3 | 242
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Carcinoma, Hepatocellular 2 | 228
Cognitive delay 2 | 608
Diabetic Nephropathies 2 | 37
Diabetic Nephropathy 2 | 34
Dysarthria 2 | 192
Global developmental delay 2 | 608
Hyperreflexia 2 | 209
Intellectual disability 2 | 1,016
Liver carcinoma 2 | 240
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Osteoarthritis 2 | 184
Paraplegia 2 | 74
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Seizures 2 | 596
acute myeloid leukemia 2 | 783
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
group 3 medulloblastoma 2 | 4,104
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
malignant mesothelioma 2 | 3,232
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Acromesomelic dysplasia 1 | 10
Acute cystitis 1 | 35
Arthropathy 1 | 43
Bladder Diverticulum 1 | 15
Bowed and upward slanting eyebrows 1 | 41
Cerebellar Dysmetria 1 | 56
Chlamydia 1 | 21
Congenital diaphragmatic hernia 1 | 67
Conjunctivitis 1 | 53
Dysentery 1 | 10
Familial cancer of breast 1 | 12
Fused vertebrae 1 | 25
Gait, Unsteady 1 | 29
Gastroenteritis 1 | 41
Glomerulonephritis 1 | 46
Gonorrhea 1 | 13
Hyperkyphosis 1 | 111
Kyphosis deformity of spine 1 | 114
Lateral sclerosis 1 | 15
Myocardial Reperfusion Injury 1 | 37
Polydactyly preaxial type 1 1 | 9
Precancerous Conditions 1 | 80
Psoriatic arthritis 1 | 86
Psychomotor Disorders 1 | 7
Psychoses, Substance-Induced 1 | 17
Reactive arthritis 1 | 7
Retinitis pigmentosa Y-linked 1 | 9
Spinal fusion 1 | 25
Spotted fever 1 | 8
Synovitis 1 | 78
Thick, flared eyebrows 1 | 41
Ventricular Dysfunction, Left 1 | 22
Vertebral body fusion 1 | 25
Vesicoureteral reflux 1 | 32
Wolf-Hirschhorn syndrome 1 | 32

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Non-IDG 12 | 12,091
Enzyme 5 | 4,145
Transporter 2 | 473
Epigenetic 1 | 242
Ion Channel 1 | 344

Reactome Pathway

Mitochondrial calcium ion tran... 21 | 21
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uniporter protein, mitochondrial MCU Tbio Ion Channel -2.67075 458.1 25
Calcium uniporter regulatory subunit MCUb, mitochondrial MCUB Tdark Non-IDG -0.76467 3.88 57
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
ATP-dependent zinc metalloprotease YME1L1 YME1L1 Tbio Enzyme -2.42377 268.0 75
Mitochondrial sodium/calcium exchanger protein SLC8B1 Tbio Transporter -1.53269 33.9 58
Voltage-dependent anion-selective channel protein 2 VDAC2 Tchem Non-IDG -1.89704 78.1 209
Mitochondrial proton/calcium exchanger protein LETM1 Tbio Non-IDG -1.54149 41.5 189
Prohibitin-2 PHB2 Tbio Non-IDG -2.95347 911.7 370
Stomatin-like protein 2, mitochondrial STOML2 Tbio Non-IDG -0.84987 9.04 154
Calcium uptake protein 2, mitochondrial MICU2 Tbio Non-IDG -0.94183 7.15 63