Development Level

Tbio 30 | 11,445
Tdark 6 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavioral response t... 1 | 66
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased grip strength 1 | 116
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased mean corpuscular hem... 1 | 96
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 21 | 11,493
ovarian cancer 19 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
psoriasis 15 | 6,694
Autosomal recessive predisposition 10 | 1,442
lung cancer 10 | 4,740
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Multiple myeloma 8 | 1,332
Muscle hypotonia 8 | 571
interstitial cystitis 8 | 2,312
Hepatomegaly 7 | 285
Hypoglycemia 7 | 152
astrocytoma 7 | 1,146
Failure to gain weight 6 | 365
Lethargy 6 | 77
Pediatric failure to thrive 6 | 365
ulcerative colitis 6 | 1,819
Cardiomyopathies 5 | 110
Hyperammonemia 5 | 30
Intellectual disability 5 | 1,016
Methylmalonic acidemia 5 | 37
Obesity 5 | 678
Propionic acidemia 5 | 16
Very long chain acyl-CoA dehydrogenase deficiency 5 | 10
Vomiting 5 | 116
glioblastoma 5 | 5,792
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
Acidosis, Lactic 4 | 97
Comatose 4 | 56
Dull intelligence 4 | 645
Dystonia 4 | 164
Epilepsy 4 | 792
Feeding difficulties in infancy 4 | 175
Lactic acidemia 4 | 95
Low intelligence 4 | 645
Medium chain acyl-CoA dehydrogenase deficiency 4 | 13
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Metabolic acidosis 4 | 90
Poor school performance 4 | 645
Seizures 4 | 596
adrenocortical carcinoma 4 | 1,428
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
subependymal giant cell astrocytoma 4 | 2,287
Anemia 3 | 365
Apnea 3 | 45
Cardiomyopathy 3 | 116
Cardiomyopathy, Dilated 3 | 83
Decreased platelet count 3 | 111
Dehydration 3 | 40
Dystonic disease 3 | 106
Elevated hepatic transaminases 3 | 81
Glycinuria 3 | 10
HYPERGLYCINURIA (disorder) 3 | 12
Hepatic enzyme increased 3 | 81
Hyperglycinemia 3 | 6
Hypoketotic hypoglycemia 3 | 11
Kidney cancer 3 | 2,613
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Myoglobinuria 3 | 15
Pancreatitis 3 | 123
Short chain acyl-CoA dehydrogenase deficiency 3 | 9
Steatohepatitis 3 | 44
Subclinical abnormal liver function tests 3 | 81
Tachypnea 3 | 20
Thrombocytopenia 3 | 197
Transaminases increased 3 | 81
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 807
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
tuberculosis 3 | 2,010
Carnitine deficiency 2 | 6
Cerebral atrophy 2 | 178
Hemoglobin low 2 | 124
Multiple acyl-CoA dehydrogenase deficiency 2 | 25
Myopathy 2 | 185
Neurodegenerative disease 2 | 414
Rhabdomyolysis 2 | 15
posterior fossa group B ependymoma 2 | 416

Tissue

Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Respiratory system 34 | 16,393

Target Family

Enzyme 30 | 4,145
Non-IDG 7 | 12,091

Reactome Pathway

Mitochondrial Fatty Acid Beta-... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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