Development Level

Tbio 9 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
decreased circulating glucose ... 1 | 126
embryonic lethality prior to t... 1 | 278
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
small testis 1 | 58

Disease

Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
group 3 medulloblastoma 7 | 4,104
Cancer 6 | 2,499
malignant mesothelioma 6 | 3,232
Lynch syndrome 5 | 35
ependymoma 5 | 4,679
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
Colorectal Neoplasms 4 | 243
Familial adenomatous polyposis 4 | 32
Kidney cancer 4 | 2,613
Xeroderma pigmentosum 4 | 43
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
psoriasis 4 | 6,694
Abdominal Pain 3 | 98
Abnormality of the abdomen 3 | 14
Adenoma 3 | 167
Anxiety 3 | 136
Anxiety disease 3 | 113
Attention deficit hyperactivity disorder 3 | 278
Axillary freckling 3 | 5
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Birthmark 3 | 35
Cafe-au-Lait Spots 3 | 37
Colorectal Neoplasms, Hereditary Nonpolyposis 3 | 9
Constipation 3 | 181
Death in early adulthood 3 | 24
Death in early childhood 3 | 82
Death in infancy 3 | 82
Depressive disorder 3 | 409
Dyschezia 3 | 135
Epilepsy 3 | 792
Fatigue 3 | 182
Gastrointestinal Hemorrhage 3 | 52
Hematologic Neoplasms 3 | 22
Hereditary Nonpolyposis Colorectal Cancer 3 | 11
Hereditary Nonpolyposis Colorectal Neoplasms 3 | 8
Hyperpigmented macules 3 | 42
Intermittent migraine headaches 3 | 68
Intracranial hypertension 3 | 32
Irritation - emotion 3 | 68
Leukemia 3 | 104
Lymphoma 3 | 81
Malabsorption 3 | 82
Malignant tumor of colon 3 | 19
Migraine Disorders 3 | 76
Muscle Hypertonia 3 | 88
Muscle hypotonia 3 | 571
Nausea and vomiting 3 | 97
Neuroblastoma 3 | 80
Rectal Neoplasms 3 | 18
Rhabdomyosarcoma 3 | 39
Sebaceous adenoma 3 | 26
Seizures 3 | 596
Turcot syndrome 3 | 5
Turcot syndrome (disorder) 3 | 5
Waldenstrons macroglobulinemia 3 | 765
Weight decreased 3 | 103
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
medulloblastoma, large-cell 3 | 6,241
non-small cell lung cancer 3 | 2,890
ovarian neoplasm 3 | 99
primitive neuroectodermal tumor 3 | 3,035
Adenocarcinoma of duodenum 2 | 2
Ataxia telangiectasia 2 | 34
Benign digestive system neoplasms 2 | 2
Benign genitourinary tract neoplasm 2 | 2
Cafe au lait spots, multiple 2 | 17
Carcinoma of larynx 2 | 2
Colon diverticulum anatomic structure 2 | 15
Colonic Neoplasms 2 | 142
Colorectal cancer 2 | 25
Diverticular disease of colon 2 | 15
Duodenal Cancer 2 | 2
Endometrial Neoplasms 2 | 55
Endometrial carcinoma 2 | 15
Fibrous skin tumor of tuberous sclerosis 2 | 18
Increased gastric cancer 2 | 21
Lynch Syndrome 1 2 | 4
Malignant genitourinary tract tumors 2 | 2
Muir-Torre syndrome 2 | 4
Neoplasm Metastasis 2 | 168
Ovarian Neoplasms 2 | 102
Prostatic Neoplasms 2 | 495
Sebaceous Adenocarcinoma 2 | 2
Stomach Neoplasms 2 | 300
Torre-Muir syndrome 2 | 3
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 6 | 4,145

Reactome Pathway

Mismatch repair (MMR) directed... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
DNA mismatch repair protein Mlh1 MLH1 Tbio Non-IDG -3.34283 2352.6 495
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.13711 11.3 1721
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
DNA ligase 1 LIG1 Tchem Enzyme -2.37512 233.9 358
DNA polymerase delta subunit 3 POLD3 Tbio Enzyme -1.31704 20.0 144