Development Level

Tbio 14 | 11,445
Tdark 9 | 6,588

IMPC Phenotype

abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
anophthalmia 1 | 33
decreased circulating HDL chol... 1 | 68
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
edema 1 | 59
enlarged lung 1 | 2
increased anti-nuclear antigen... 1 | 19
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 17 | 11,493
glioblastoma 13 | 5,792
osteosarcoma 13 | 7,950
ovarian cancer 13 | 8,520
atypical teratoid / rhabdoid tumor 12 | 5,112
medulloblastoma, large-cell 12 | 6,241
adult high grade glioma 10 | 3,801
astrocytic glioma 10 | 2,597
oligodendroglioma 10 | 2,850
ependymoma 9 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
psoriasis 9 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung cancer 8 | 4,740
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
primitive neuroectodermal tumor 7 | 3,035
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
subependymal giant cell astrocytoma 6 | 2,287
Pick disease 5 | 1,894
cystic fibrosis 4 | 1,696
lung adenocarcinoma 4 | 2,716
ulcerative colitis 4 | 1,819
Angelman syndrome 3 | 34
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Prader-Willi syndrome 3 | 48
Prostatic Neoplasms 3 | 495
breast carcinoma 3 | 1,638
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Agammaglobulinemia 2 | 34
Alzheimer's disease 2 | 658
Autosomal recessive predisposition 2 | 1,442
Cystinosis 2 | 14
Duchenne muscular dystrophy 2 | 601
Multiple myeloma 2 | 1,332
Rheumatoid arthritis 2 | 1,191
Sinusitis 2 | 65
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
chronic rhinosinusitis 2 | 512
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
fibroadenoma 2 | 559
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 468
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE 1 | 8
Abnormal urinary amino-acid findings 1 | 38
Agammaglobulinemia, non-Bruton type 1 | 8
Aminoaciduria 1 | 38
Ankylosis 1 | 28
Batten disease 1 | 13
Breast disease 1 | 7
CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT 1 | 1
Calcium pyrophosphate arthropathy 1 | 1
Chondrocalcinosis 1 | 9
Chondrocalcinosis 2 1 | 1
Chronic kidney disease stage 5 1 | 31
Congenital ichthyosiform erythroderma 1 | 28
Craniometaphyseal dysplasia 1 | 5
Dehydration 1 | 40
Delayed Puberty 1 | 97
Echolalia 1 | 12
Ectropion 1 | 38
Epidermodysplasia verruciformis 1 | 21
Exhibitionism 1 | 7
Exocrine pancreatic insufficiency 1 | 32
Facial paralysis 1 | 18
Familial chondrocalcinosis 1 | 1
Fanconi syndrome 1 | 14
Hyperchloremic metabolic acidosis 1 | 5
Hyperostosis 1 | 18
Hypokalemia 1 | 52
Hypophosphatasia 1 | 10
Lobular neoplasia 1 | 15
Microscopic hematuria 1 | 9
Nephritis, Tubulointerstitial 1 | 8
Osteosclerosis 1 | 31
Pancreatic Insufficiency 1 | 13
Periarthritis 1 | 6
Polydipsia 1 | 15
Polyuria 1 | 23
Reduced visual acuity 1 | 63
Schwartz-Lelek syndrome 1 | 2
Tooth Abnormalities 1 | 69

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 2 | 4,145

Reactome Pathway

Miscellaneous transport and bi... 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Magnesium transporter MRS2 homolog, mitochondrial MRS2 Tbio Non-IDG -2.52322 327.4 39
Volume-regulated anion channel subunit LRRC8A LRRC8A Tbio Non-IDG -1.55179 39.4 129
Magnesium transporter NIPA1 NIPA1 Tbio Non-IDG -1.41490 24.2 20
Magnesium transporter protein 1 MAGT1 Tbio Non-IDG -1.60224 37.5 86
Magnesium transporter NIPA4 NIPAL4 Tbio Non-IDG -1.20246 15.0 58
Lysosomal amino acid transporter 1 homolog PQLC2 Tdark Non-IDG -0.24304 2.13 66
Magnesium transporter NIPA3 NIPAL1 Tdark Non-IDG -0.17609 0.67 57
NIPA-like protein 2 NIPAL2 Tdark Non-IDG -0.30103 2.00 85
Cystinosin CTNS Tbio Non-IDG -2.31471 205.6 165
Magnesium transporter NIPA2 NIPA2 Tbio Non-IDG -0.92140 7.99 26