Development Level

Tbio 23 | 11,445

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal retina morphology 1 | 71
absent spleen 1 | 3
decreased circulating sodium l... 1 | 22
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
increased circulating free fat... 1 | 20
increased grip strength 1 | 41

Disease

ovarian cancer 15 | 8,520
Carcinoma 13 | 11,493
osteosarcoma 9 | 7,950
psoriasis 8 | 6,694
Multiple myeloma 7 | 1,332
atypical teratoid / rhabdoid tumor 6 | 5,112
lung cancer 6 | 4,740
medulloblastoma, large-cell 6 | 6,241
Cancer 5 | 2,499
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
Breast cancer 4 | 3,578
Hereditary spherocytosis type 5 4 | 12
Kidney cancer 4 | 2,613
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
Wilms Tumor 4 | 28
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
malignant mesothelioma 4 | 3,232
primitive neuroectodermal tumor 4 | 3,035
Schizophrenia 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
Amyotrophic lateral sclerosis 2 | 451
Chikungunya 2 | 16
Cockayne syndrome 2 | 60
Congenital myasthenic syndrome 5 2 | 11
DiGeorge syndrome 2 | 47
Intellectual disability 2 | 1,016
Microsatellite Instability 2 | 12
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
non primary Sjogren syndrome sicca 2 | 891
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
Abnormality of metabolism/homeostasis 1 | 134
Abnormality of the endocrine system 1 | 9
Animal Mammary Neoplasms 1 | 136
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Ciliary Dyskinesia, Primary, 1 1 | 27
Craniofacial Abnormalities 1 | 151
Deglutition Disorders 1 | 132
Dystonia Disorders 1 | 6
Dystonia, Limb 1 | 9
Dystonic Disorders 1 | 7
Embryotoxon 1 | 28
Endocrine System Diseases 1 | 11
Endometriosis of ovary 1 | 5
Gaucher disease type 1 1 | 180
Goiter 1 | 38
Goodpasture syndrome 1 | 6
Granulosa cell tumor 1 | 6
HIV Infections 1 | 102
Hypocalcemia 1 | 32
Hypomyelinating leukodystrophy 6 1 | 26
Keloid 1 | 37
La Crosse encephalitis 1 | 5
Laryngeal dystonia 1 | 5
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Mood swings 1 | 77
Nonorganic psychosis 1 | 84
Oligospermia 1 | 36
Open mouth 1 | 45
Panic disorder 1 | 61
Papillary thyroid carcinoma 1 | 43
Parkinsonian Disorders 1 | 56
Posterior embryotoxon 1 | 28
Recurrent infections 1 | 48
Renal Cell Carcinoma 1 | 214
Retrognathia 1 | 54
Rhabdomyosarcoma 1 | 39
Seminoma 1 | 15
Static Tremor 1 | 21
Tetralogy of Fallot 1 | 63
Velocardiofacial syndrome 1 | 46
Waterhouse-Friderichsen syndrome 1 | 11
Xeroderma pigmentosum group B 1 | 20
ovarian neoplasm 1 | 99
permanent atrial fibrillation 1 | 45
sarcoidosis 1 | 370

Tissue

Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678

Target Family

Enzyme 16 | 4,145
Non-IDG 6 | 12,091
Kinase 1 | 634

Reactome Pathway

MicroRNA (miRNA) biogenesis 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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