Development Level

Tbio 114 | 10,625
Tchem 43 | 1,890
Tdark 8 | 7,003
Tclin 7 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to t... 6 | 187
decreased circulating glucose ... 4 | 121
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
decreased threshold for audito... 3 | 32
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
enlarged heart 3 | 111
small kidney 3 | 10
abnormal bone structure 2 | 131
abnormal rib morphology 2 | 28
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
absent vibrissae 2 | 14
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating lipase l... 2 | 2
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased leukocyte cell numbe... 2 | 54
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
small adrenal glands 2 | 15
abnormal behavioral response t... 1 | 52
abnormal brain morphology 1 | 6
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal jejunum morphology 1 | 1
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal pelvic girdle bone mo... 1 | 11
abnormal pericardium morpholog... 1 | 11
abnormal radius morphology 1 | 8
abnormal response to new envir... 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal sensory capabilities/... 1 | 3
abnormal skin appearance 1 | 8
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
craniofacial phenotype 1 | 9
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased vertical activity 1 | 22
female infertility 1 | 34
hydroencephaly 1 | 6
hydrops fetalis 1 | 22
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased respiratory quotient 1 | 12
microphthalmia 1 | 15
mydriasis 1 | 9
pale yolk sac 1 | 12
pallor 1 | 13
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small heart 1 | 8
small spleen 1 | 11

Disease

ovarian cancer 93 | 8,484
osteosarcoma 88 | 7,933
psoriasis 85 | 6,685
medulloblastoma, large-cell 60 | 6,234
lung cancer 58 | 4,466
glioblastoma 53 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,956
invasive ductal carcinoma 46 | 2,950
non-small cell lung cancer 45 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
lung carcinoma 40 | 2,844
malignant mesothelioma 40 | 3,162
Cancer 39 | 2,346
lung adenocarcinoma 39 | 2,713
atypical teratoid / rhabdoid tumor 38 | 4,369
Breast cancer 37 | 3,094
ductal carcinoma in situ 35 | 1,745
interstitial cystitis 35 | 2,299
diabetes mellitus 34 | 1,663
pancreatic cancer 34 | 2,300
cystic fibrosis 28 | 1,665
ulcerative colitis 28 | 2,087
Obesity 27 | 616
pilocytic astrocytoma 27 | 3,086
pediatric high grade glioma 26 | 2,712
primitive neuroectodermal tumor 26 | 3,031
breast carcinoma 25 | 1,614
subependymal giant cell astrocytoma 25 | 2,287
pituitary cancer 24 | 1,972
adrenocortical carcinoma 23 | 1,427
oligodendroglioma 23 | 2,849
adult high grade glioma 21 | 2,148
astrocytic glioma 20 | 2,241
group 3 medulloblastoma 20 | 2,254
group 4 medulloblastoma 19 | 1,875
tuberculosis 19 | 1,557
Atopic dermatitis 18 | 944
Carcinoma 18 | 2,147
active Crohn's disease 18 | 918
colon cancer 18 | 1,475
primary pancreatic ductal adenocarcinoma 18 | 1,271
Multiple myeloma 17 | 1,327
active ulcerative colitis 16 | 477
astrocytoma 15 | 1,493
ependymoma 15 | 2,514
Atherosclerosis 14 | 275
Vitamin B12 deficiency 14 | 20
dermatomyositis 14 | 933
posterior fossa group B ependymoma 14 | 1,530
primary Sjogren syndrome 14 | 789
sonic hedgehog group medulloblastoma 14 | 1,482
Methylmalonic acidemia 13 | 39
Pick disease 13 | 1,893
Rheumatoid Arthritis 13 | 1,160
medulloblastoma 13 | 1,524
Alzheimer's disease 12 | 644
Coronary artery disease 12 | 240
Kidney disease 12 | 396
cutaneous lupus erythematosus 12 | 1,056
spina bifida 12 | 1,064
Colorectal Neoplasms 11 | 217
atypical teratoid/rhabdoid tumor 11 | 1,095
fibroadenoma 11 | 557
nasopharyngeal carcinoma 11 | 1,056
nephrosclerosis 11 | 329
non primary Sjogren syndrome sicca 11 | 840
posterior fossa group A ependymoma 11 | 1,511
Anemia 10 | 252
Down syndrome 10 | 548
Drug-Induced Liver Injury 10 | 118
Metabolic syndrome X 10 | 155
Polycystic Ovary Syndrome 10 | 332
acute myeloid leukemia 10 | 780
acute quadriplegic myopathy 10 | 1,157
gastric carcinoma 10 | 832
juvenile dermatomyositis 10 | 1,189
Adverse reaction to drug 9 | 54
Cerebrovascular disease 9 | 231
Duchenne muscular dystrophy 9 | 602
Homocystinuria 9 | 23
Hypertension 9 | 287
Lipid metabolism disorder 9 | 102
Lung Neoplasms 9 | 171
Pancreatitis 9 | 97
Prostatic Neoplasms 9 | 471
aldosterone-producing adenoma 9 | 664
esophageal adenocarcinoma 9 | 737
Coronary heart disease 8 | 59
Endometriosis 8 | 535
Hyperhomocysteinemia 8 | 34
Mammary Neoplasms 8 | 410
Schizophrenia 8 | 501
Stomach Neoplasms 8 | 282
chronic rhinosinusitis 8 | 512
Vascular disease 7 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
inflammatory breast cancer 7 | 404
mucosa-associated lymphoid tissue lymphoma 7 | 480

Tissue

Blood and immune system 171 | 17,995
Cardiovascular System 171 | 17,958
Digestive Tract 171 | 18,473
Endocrine System 171 | 18,512
Female tissues 171 | 18,647
Liver and Pancreas 171 | 18,136
Male tissues 171 | 17,969
Nervous System 171 | 18,561
Urinary Tract 171 | 18,444
Respiratory system 170 | 17,484
Skin and soft tissues 169 | 18,115

Target Family

Enzyme 97 | 4,146
Non-IDG 47 | 11,971
Transporter 19 | 473
Kinase 9 | 634

Reactome Pathway

Metabolism of vitamins and cof... 172 | 172
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788