Development Level

Tbio 86 | 11,445
Tchem 49 | 1,598
Tclin 17 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased total body fat amoun... 7 | 207
abnormal behavior 6 | 298
abnormal embryo size 6 | 220
abnormal heart morphology 5 | 162
decreased circulating choleste... 5 | 93
decreased circulating glucose ... 5 | 126
increased circulating alkaline... 5 | 122
preweaning lethality, incomple... 5 | 499
abnormal retina morphology 4 | 71
decreased circulating HDL chol... 4 | 68
decreased vertical activity 4 | 208
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
abnormal lens morphology 3 | 81
abnormal neural tube closure 3 | 46
cataract 3 | 92
decreased circulating serum al... 3 | 82
enlarged heart 3 | 210
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased total body fat amoun... 3 | 134
microphthalmia 3 | 26
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
abnormal forebrain development 2 | 20
abnormal seminal vesicle morph... 2 | 114
anophthalmia 2 | 33
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating free fat... 2 | 31
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased mean corpuscular vol... 2 | 79
hydrometra 2 | 53
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating alanine ... 2 | 13
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased startle reflex 2 | 112
short tibia 2 | 97
small kidney 2 | 16
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
enlarged uterus 1 | 11
hemorrhage 1 | 23
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
small spleen 1 | 19
small superior vagus ganglion 1 | 74

Disease

Carcinoma 105 | 11,493
ovarian cancer 87 | 8,520
psoriasis 76 | 6,694
osteosarcoma 71 | 7,950
malignant mesothelioma 53 | 3,232
medulloblastoma, large-cell 53 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,962
glioblastoma 45 | 5,792
lung cancer 45 | 4,740
Cancer 41 | 2,499
atypical teratoid / rhabdoid tumor 40 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
Autosomal recessive predisposition 37 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
Breast cancer 33 | 3,578
adult high grade glioma 30 | 3,801
invasive ductal carcinoma 30 | 2,951
group 3 medulloblastoma 29 | 4,104
Pick disease 27 | 1,894
pancreatic cancer 26 | 2,398
pituitary cancer 26 | 1,972
ependymoma 25 | 4,679
non-small cell lung cancer 25 | 2,890
subependymal giant cell astrocytoma 25 | 2,287
ductal carcinoma in situ 24 | 1,745
interstitial cystitis 24 | 2,312
active Crohn's disease 23 | 922
Kidney cancer 22 | 2,613
lung carcinoma 22 | 2,843
Obesity 21 | 678
Prostatic Neoplasms 21 | 495
cystic fibrosis 21 | 1,696
lung adenocarcinoma 21 | 2,716
oligodendroglioma 21 | 2,850
tuberculosis 21 | 2,010
Astrocytoma, Pilocytic 20 | 3,081
Cholestasis 20 | 155
Failure to gain weight 19 | 365
Pediatric failure to thrive 19 | 365
adrenocortical carcinoma 19 | 1,428
astrocytoma 19 | 1,146
Liver Cirrhosis, Experimental 18 | 769
astrocytic glioma 18 | 2,597
diabetes mellitus 18 | 1,728
Carcinoma, Hepatocellular 17 | 228
Liver carcinoma 17 | 240
Osteoporosis 16 | 363
Polycystic ovary syndrome 16 | 360
acute quadriplegic myopathy 16 | 1,158
group 4 medulloblastoma 16 | 1,855
breast carcinoma 15 | 1,638
Atopic dermatitis 14 | 952
Intellectual disability 14 | 1,016
Schizophrenia 14 | 1,160
Short stature 14 | 531
active ulcerative colitis 14 | 764
aldosterone-producing adenoma 14 | 665
colon cancer 14 | 1,478
Congenital adrenal hyperplasia 13 | 73
Fatty liver disease 13 | 103
Rheumatoid arthritis 13 | 1,191
Waldenstrons macroglobulinemia 13 | 765
dermatomyositis 13 | 966
ulcerative colitis 13 | 1,819
Cryptorchidism 12 | 296
Endometriosis 12 | 540
Epilepsy 12 | 792
Hypertension 12 | 396
Liver disease 12 | 237
Multiple myeloma 12 | 1,332
Muscle hypotonia 12 | 571
chronic rhinosinusitis 12 | 512
primitive neuroectodermal tumor 12 | 3,035
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Hypertensive disease 11 | 292
Mental and motor retardation 11 | 608
Seizures 11 | 596
nephrosclerosis 11 | 333
Alzheimer's disease 10 | 658
Breast Neoplasms 10 | 445
Cataract 10 | 297
Dull intelligence 10 | 645
Hepatomegaly 10 | 285
Kidney disease 10 | 430
Lipid metabolism disorder 10 | 114
Low intelligence 10 | 645
Mammary Neoplasms 10 | 425
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Atherosclerosis 9 | 291
Bipolar Disorder 9 | 666
Low set ears 9 | 181
Multiple Sclerosis 9 | 540
nasopharyngeal carcinoma 9 | 1,058
pediatric high grade glioma 9 | 1,064
progressive supranuclear palsy 9 | 676
spina bifida 9 | 1,074

Tissue

Endocrine System 152 | 18,159
Digestive Tract 150 | 17,369
Liver and Pancreas 149 | 16,750
Male tissues 149 | 17,142
Female tissues 148 | 17,400
Skin and soft tissues 148 | 17,230
Urinary Tract 148 | 16,678
Blood and immune system 143 | 16,909
Nervous System 142 | 16,725
Respiratory system 142 | 16,393
Cardiovascular System 128 | 15,192

Target Family

Enzyme 77 | 4,145
Non-IDG 48 | 12,091
Transcription Factor 8 | 1,400
Transporter 8 | 473
Nuclear Receptor 7 | 48
Epigenetic 5 | 242
Kinase 1 | 634

Reactome Pathway

Metabolism of steroids 154 | 154
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Oxysterol-binding protein-related protein 1 OSBPL1A Tbio Non-IDG -0.69214 5.13 145
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
Putative peripheral benzodiazepine receptor-related protein TSPO Tchem Non-IDG -3.08695 2284.2 212
Sodium/bile acid cotransporter SLC10A1 Tchem Transporter -2.69150 476.1 163
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137