Development Level

Tbio 1,544 | 11,651
Tdark 292 | 6,593
Tchem 202 | 1,388
Tclin 53 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 211 | 979
preweaning lethality, incomple... 59 | 499
embryonic lethality prior to o... 58 | 239
embryonic lethality prior to t... 53 | 278
abnormal embryo size 36 | 220
abnormal behavior 29 | 298
decreased total body fat amoun... 29 | 207
enlarged heart 27 | 210
decreased body weight 23 | 161
decreased vertical activity 23 | 208
increased total body fat amoun... 23 | 134
decreased lean body mass 21 | 135
abnormal seminal vesicle morph... 20 | 114
decreased bone mineral content 20 | 151
decreased circulating choleste... 20 | 93
abnormal heart morphology 19 | 162
embryonic growth retardation 19 | 106
decreased circulating glucose ... 18 | 126
increased lean body mass 17 | 172
abnormal bone structure 16 | 187
hypoactivity 16 | 132
decreased hemoglobin content 15 | 68
increased circulating alkaline... 14 | 122
increased mean corpuscular hem... 14 | 96
increased mean corpuscular vol... 14 | 92
prenatal lethality prior to he... 14 | 87
short tibia 13 | 97
cataract 12 | 92
decreased circulating HDL chol... 12 | 68
decreased grip strength 12 | 116
decreased mean corpuscular hem... 12 | 50
hyperactivity 12 | 148
decreased body length 11 | 101
impaired glucose tolerance 11 | 75
abnormal lens morphology 10 | 81
decreased circulating alanine ... 10 | 47
decreased circulating serum al... 10 | 82
decreased circulating total pr... 10 | 49
decreased mean corpuscular vol... 10 | 79
increased blood urea nitrogen ... 10 | 48
increased circulating HDL chol... 10 | 80
increased circulating triglyce... 10 | 42
increased fasted circulating g... 10 | 76
increased heart weight 10 | 62
increased startle reflex 10 | 112
decreased caudal vertebrae num... 9 | 53
decreased circulating aspartat... 9 | 34
decreased startle reflex 9 | 75
increased circulating choleste... 9 | 66
increased or absent threshold ... 9 | 101
male infertility 9 | 123
abnormal coat-hair pigmentatio... 8 | 64
abnormal kidney morphology 8 | 65
abnormal neural tube closure 8 | 46
anophthalmia 8 | 33
decreased bone mineral density 8 | 126
decreased circulating LDL chol... 8 | 38
decreased circulating creatini... 8 | 39
decreased circulating fructosa... 8 | 30
decreased circulating insulin ... 8 | 76
decreased circulating triglyce... 8 | 79
decreased erythrocyte cell num... 8 | 62
decreased fasted circulating g... 8 | 65
decreased hematocrit 8 | 46
decreased red blood cell distr... 8 | 41
improved glucose tolerance 8 | 79
abnormal bone mineralization 7 | 38
abnormal craniofacial morpholo... 7 | 33
decreased blood urea nitrogen ... 7 | 51
edema 7 | 59
increased bone mineral content 7 | 108
increased circulating chloride... 7 | 41
increased circulating creatini... 7 | 38
increased hemoglobin content 7 | 45
increased mean platelet volume 7 | 45
increased red blood cell distr... 7 | 34
prolonged ST segment 7 | 36
syndactyly 7 | 23
abnormal cranium morphology 6 | 36
abnormal embryo turning 6 | 31
abnormal eye morphology 6 | 68
abnormal lung morphology 6 | 26
abnormal spleen morphology 6 | 55
brachydactyly 6 | 19
decreased circulating chloride... 6 | 30
decreased circulating iron lev... 6 | 32
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
hydrometra 6 | 53
increased bone mineral density 6 | 72
increased hematocrit 6 | 46
increased mean corpuscular hem... 6 | 36
prolonged QT interval 6 | 38
small superior vagus ganglion 6 | 74
thrombocytopenia 6 | 56
thrombocytosis 6 | 27
vertebral fusion 6 | 23
abnormal limb bud morphology 5 | 17
pale yolk sac 5 | 25
pallor 5 | 34

Disease

Carcinoma 1,187 | 11,493
ovarian cancer 1,168 | 8,520
osteosarcoma 878 | 7,950
psoriasis 761 | 6,694
glioblastoma 673 | 5,792
medulloblastoma, large-cell 661 | 6,241
lung cancer 648 | 4,740
atypical teratoid / rhabdoid tumor 564 | 5,112
ependymoma 469 | 4,679
Breast cancer 444 | 3,578
Cancer 400 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 392 | 3,291
group 3 medulloblastoma 387 | 4,104
malignant mesothelioma 386 | 3,232
adult high grade glioma 379 | 3,801
non-small cell lung cancer 351 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 349 | 2,955
diabetes mellitus 342 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 341 | 2,989
lung adenocarcinoma 330 | 2,716
Multiple myeloma 320 | 1,332
invasive ductal carcinoma 320 | 2,951
Astrocytoma, Pilocytic 301 | 3,081
primitive neuroectodermal tumor 294 | 3,035
oligodendroglioma 293 | 2,850
astrocytic glioma 291 | 2,597
pancreatic cancer 291 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 289 | 1,962
lung carcinoma 275 | 2,843
Kidney cancer 259 | 2,613
tuberculosis 253 | 2,010
Autosomal recessive predisposition 234 | 1,442
subependymal giant cell astrocytoma 220 | 2,287
group 4 medulloblastoma 200 | 1,855
cystic fibrosis 199 | 1,696
Pick disease 195 | 1,894
breast carcinoma 191 | 1,638
pituitary cancer 191 | 1,972
dermatomyositis 189 | 966
ulcerative colitis 187 | 1,819
interstitial cystitis 184 | 2,312
Rheumatoid arthritis 183 | 1,191
acute quadriplegic myopathy 173 | 1,158
colon cancer 159 | 1,478
ductal carcinoma in situ 159 | 1,745
juvenile dermatomyositis 159 | 1,187
astrocytoma 151 | 1,146
adrenocortical carcinoma 143 | 1,428
Waldenstrons macroglobulinemia 140 | 765
Intellectual disability 136 | 1,016
Epilepsy 134 | 792
primary pancreatic ductal adenocarcinoma 126 | 1,109
Schizophrenia 125 | 1,160
pediatric high grade glioma 125 | 1,064
non primary Sjogren syndrome sicca 122 | 891
Seizures 120 | 596
active Crohn's disease 120 | 922
Cognitive delay 113 | 608
Global developmental delay 113 | 608
Mental and motor retardation 113 | 608
Muscle hypotonia 111 | 571
acute myeloid leukemia 110 | 783
nasopharyngeal carcinoma 108 | 1,058
cutaneous lupus erythematosus 104 | 1,057
Arthritis 102 | 290
spina bifida 100 | 1,074
Kidney disease 99 | 430
Obesity 94 | 678
Anemia 93 | 365
Alzheimer's disease 91 | 658
Atopic dermatitis 91 | 952
Liver Cirrhosis, Experimental 90 | 769
Prostatic Neoplasms 90 | 495
Short stature 89 | 531
gastric carcinoma 89 | 807
esophageal adenocarcinoma 87 | 737
Duchenne muscular dystrophy 86 | 601
Hypersensitivity reaction type II disease 84 | 253
Small head 84 | 374
Breast Neoplasms 82 | 445
Dull intelligence 81 | 645
Low intelligence 81 | 645
Mammary Neoplasms 81 | 425
Mental Retardation 81 | 645
Mental deficiency 81 | 645
Poor school performance 81 | 645
active ulcerative colitis 80 | 764
hepatocellular carcinoma 79 | 547
Bipolar Disorder 77 | 666
Melanoma 76 | 711
sonic hedgehog group medulloblastoma 76 | 467
Liver disease 75 | 237
Neurodegenerative disease 74 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 74 | 510
Failure to gain weight 72 | 365
Hypertension 72 | 396
Pediatric failure to thrive 72 | 365
Acquired immunodeficiency syndrome 71 | 197
medulloblastoma 70 | 720
Ankylosing spondylitis 68 | 140

Tissue

Endocrine System 1,985 | 18,159
Digestive Tract 1,968 | 17,369
Female tissues 1,963 | 17,400
Skin and soft tissues 1,959 | 17,230
Liver and Pancreas 1,944 | 16,750
Male tissues 1,940 | 17,142
Blood and immune system 1,935 | 16,909
Urinary Tract 1,934 | 16,678
Nervous System 1,925 | 16,725
Respiratory system 1,914 | 16,393
Cardiovascular System 1,838 | 15,192

Target Family

Non-IDG 1,221 | 12,091
Enzyme 735 | 4,145
Transcription Factor 56 | 1,400
Epigenetic 24 | 242
Kinase 24 | 634
Transporter 15 | 473
GPCR 11 | 408
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism of proteins 2,091 | 2,091
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0