Development Level

Tbio 1,095 | 10,625
Tchem 220 | 1,890
Tdark 185 | 7,003
Tclin 45 | 602

Collection

Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 115 | 633
embryonic lethality prior to t... 33 | 187
embryonic lethality prior to o... 28 | 148
preweaning lethality, incomple... 25 | 260
decreased body weight 20 | 174
decreased lean body mass 20 | 195
decreased total body fat amoun... 18 | 186
abnormal behavior 17 | 226
enlarged heart 15 | 111
increased circulating alkaline... 15 | 119
decreased circulating choleste... 14 | 85
decreased bone mineral content 13 | 157
increased or absent threshold ... 12 | 128
decreased grip strength 11 | 123
increased sacral vertebrae num... 11 | 62
prenatal lethality prior to he... 11 | 64
abnormal embryo size 10 | 112
decreased body length 10 | 108
decreased circulating glucose ... 10 | 121
decreased hemoglobin content 10 | 53
increased mean corpuscular hem... 10 | 93
increased mean corpuscular vol... 10 | 91
decreased circulating HDL chol... 9 | 77
decreased circulating triglyce... 9 | 83
decreased lumbar vertebrae num... 9 | 62
increased blood urea nitrogen ... 9 | 44
increased exploration in new e... 9 | 56
increased grip strength 9 | 83
short tibia 9 | 82
decreased caudal vertebrae num... 8 | 49
increased heart weight 8 | 37
abnormal bone mineralization 7 | 55
abnormal coat/hair pigmentatio... 7 | 54
abnormal lens morphology 7 | 73
abnormal retinal pigmentation 7 | 61
decreased circulating alanine ... 7 | 53
decreased circulating total pr... 7 | 41
decreased fasted circulating g... 7 | 49
decreased mean corpuscular vol... 7 | 50
decreased startle reflex 7 | 48
hyperactivity 7 | 108
abnormal heart morphology 6 | 51
abnormal seminal vesicle morph... 6 | 47
decreased T cell number 6 | 31
decreased bone mineral density 6 | 126
decreased circulating LDL chol... 6 | 37
decreased circulating fructosa... 6 | 31
decreased circulating insulin ... 6 | 75
decreased mean corpuscular hem... 6 | 34
decreased rib number 6 | 59
increased fasted circulating g... 6 | 68
increased total body fat amoun... 6 | 57
abnormal bone structure 5 | 131
abnormal retina morphology 5 | 100
abnormal spleen morphology 5 | 36
anophthalmia 5 | 20
decreased B cell number 5 | 30
decreased circulating aspartat... 5 | 27
decreased effector memory CD8-... 5 | 24
hypoactivity 5 | 89
increased CD4-positive, alpha ... 5 | 15
increased circulating HDL chol... 5 | 63
increased circulating chloride... 5 | 43
increased circulating choleste... 5 | 53
increased circulating sodium l... 5 | 71
thrombocytopenia 5 | 46
thrombocytosis 5 | 23
vertebral fusion 5 | 23
abnormal coping response 4 | 12
abnormal gait 4 | 51
abnormal neural tube closure 4 | 37
cataract 4 | 26
decreased CD4-positive, CD25-p... 4 | 24
decreased CD8-positive, alpha-... 4 | 26
decreased KLRG1-positive NK ce... 4 | 9
decreased Ly6C low monocyte nu... 4 | 23
decreased circulating alkaline... 4 | 41
decreased circulating free fat... 4 | 39
decreased circulating serum al... 4 | 79
decreased eosinophil cell numb... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased hematocrit 4 | 25
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
increased bone mineral content 4 | 92
increased circulating phosphat... 4 | 24
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
increased lean body mass 4 | 107
increased monocyte cell number 4 | 27
polydactyly 4 | 22
abnormal head morphology 3 | 10
cardiovascular system phenotyp... 3 | 35
decreased circulating calcium ... 3 | 33
decreased circulating glycerol... 3 | 19
impaired glucose tolerance 3 | 52
increased circulating aspartat... 3 | 17
increased circulating fructosa... 3 | 11
increased hematocrit 3 | 36
small testis 3 | 37

Disease

ovarian cancer 869 | 8,484
osteosarcoma 680 | 7,933
psoriasis 559 | 6,685
glioblastoma 506 | 5,572
medulloblastoma, large-cell 501 | 6,234
lung cancer 485 | 4,466
atypical teratoid / rhabdoid tumor 390 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 318 | 3,289
Breast cancer 296 | 3,094
malignant mesothelioma 284 | 3,162
lung adenocarcinoma 273 | 2,713
non-small cell lung cancer 271 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 270 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 270 | 2,988
Cancer 261 | 2,346
Multiple myeloma 249 | 1,327
invasive ductal carcinoma 246 | 2,950
pilocytic astrocytoma 245 | 3,086
oligodendroglioma 230 | 2,849
primitive neuroectodermal tumor 228 | 3,031
pancreatic cancer 226 | 2,300
pediatric high grade glioma 225 | 2,712
diabetes mellitus 221 | 1,663
lung carcinoma 214 | 2,844
ependymoma 200 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 192 | 1,795
group 3 medulloblastoma 189 | 2,254
astrocytic glioma 185 | 2,241
ulcerative colitis 168 | 2,087
subependymal giant cell astrocytoma 165 | 2,287
Carcinoma 161 | 2,147
cystic fibrosis 159 | 1,665
adult high grade glioma 155 | 2,148
astrocytoma 153 | 1,493
Pick disease 152 | 1,893
interstitial cystitis 150 | 2,299
pituitary cancer 146 | 1,972
breast carcinoma 142 | 1,614
group 4 medulloblastoma 140 | 1,875
posterior fossa group A ependymoma 138 | 1,511
tuberculosis 134 | 1,557
acute quadriplegic myopathy 131 | 1,157
ductal carcinoma in situ 125 | 1,745
dermatomyositis 124 | 933
Rheumatoid Arthritis 122 | 1,160
juvenile dermatomyositis 121 | 1,189
medulloblastoma 119 | 1,524
colon cancer 117 | 1,475
sonic hedgehog group medulloblastoma 115 | 1,482
primary pancreatic ductal adenocarcinoma 110 | 1,271
Waldenstrons macroglobulinemia 109 | 765
adrenocortical carcinoma 108 | 1,427
active Crohn's disease 102 | 918
posterior fossa group B ependymoma 90 | 1,530
cutaneous lupus erythematosus 89 | 1,056
acute myeloid leukemia 81 | 780
nasopharyngeal carcinoma 81 | 1,056
spina bifida 79 | 1,064
non primary Sjogren syndrome sicca 78 | 840
atypical teratoid/rhabdoid tumor 77 | 1,095
Alzheimer's disease 71 | 644
Prostatic Neoplasms 71 | 471
esophageal adenocarcinoma 70 | 737
Obesity 69 | 616
Atopic dermatitis 68 | 944
tuberculosis and treatment for 6 months 65 | 686
gastric carcinoma 64 | 832
Duchenne muscular dystrophy 62 | 602
Intellectual disability 62 | 573
pancreatic carcinoma 59 | 567
hepatocellular carcinoma 58 | 532
Mammary Neoplasms 57 | 410
IGA Glomerulonephritis 56 | 454
primary Sjogren syndrome 56 | 789
Neurodegenerative disease 54 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 53 | 499
Kidney disease 52 | 396
non-small cell lung carcinoma 51 | 413
Endometriosis 48 | 535
Vascular disease 47 | 281
Down syndrome 46 | 548
Parkinson's disease 46 | 364
Stomach Neoplasms 46 | 282
Amyotrophic Lateral Sclerosis 44 | 431
Schizophrenia 44 | 501
inflammatory breast cancer 44 | 404
Atherosclerosis 43 | 275
Polycystic Ovary Syndrome 42 | 332
mucosa-associated lymphoid tissue lymphoma 42 | 480
fibroadenoma 41 | 557
gastric cancer 41 | 430
Congenital disorder of glycosylation 40 | 53
aldosterone-producing adenoma 40 | 664
Asthma 38 | 349
Hypertension 38 | 287
Liver carcinoma 38 | 217
active ulcerative colitis 38 | 477
Anemia 37 | 252
Heart disease 35 | 279
progressive supranuclear palsy 35 | 674

Tissue

Nervous System 1,530 | 18,561
Female tissues 1,529 | 18,647
Blood and immune system 1,521 | 17,995
Digestive Tract 1,519 | 18,473
Urinary Tract 1,517 | 18,444
Endocrine System 1,515 | 18,512
Liver and Pancreas 1,513 | 18,136
Male tissues 1,509 | 17,969
Cardiovascular System 1,501 | 17,958
Skin and soft tissues 1,498 | 18,115
Respiratory system 1,489 | 17,484

Target Family

Non-IDG 820 | 11,971
Enzyme 610 | 4,146
Transcription Factor 44 | 1,400
Kinase 23 | 634
Epigenetic 18 | 242
Transporter 14 | 473
GPCR 11 | 406
Ion Channel 2 | 341
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism of proteins 1,545 | 1,545
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97