Development Level

Tbio 47 | 10,625
Tchem 31 | 1,890
Tclin 14 | 602
Tdark 3 | 7,003

IMPC Phenotype

embryonic lethality prior to o... 4 | 148
preweaning lethality, complete... 4 | 633
abnormal epididymis morphology 2 | 31
decreased circulating glycerol... 2 | 19
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal heart morphology 1 | 51
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal sacral vertebrae morp... 1 | 5
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased CD8-positive, naive ... 1 | 5
decreased KLRG1-positive CD4-p... 1 | 1
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased monocyte cell number 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
increased T cell number 1 | 15
increased circulating chloride... 1 | 43
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased memory CD4-positive,... 1 | 3
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 52 | 8,491
medulloblastoma, large-cell 49 | 6,234
lung cancer 45 | 4,473
psoriasis 43 | 6,685
osteosarcoma 41 | 7,933
glioblastoma 34 | 5,572
Cancer 25 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
Breast cancer 23 | 3,098
atypical teratoid / rhabdoid tumor 23 | 4,369
non-small cell lung cancer 22 | 2,798
malignant mesothelioma 21 | 3,163
tuberculosis 21 | 1,563
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
pediatric high grade glioma 19 | 2,712
primitive neuroectodermal tumor 19 | 3,031
group 3 medulloblastoma 18 | 2,254
invasive ductal carcinoma 18 | 2,950
pancreatic cancer 18 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
oligodendroglioma 17 | 2,849
ependymoma 16 | 2,514
lung adenocarcinoma 16 | 2,714
interstitial cystitis 15 | 2,299
pilocytic astrocytoma 15 | 3,086
medulloblastoma 13 | 1,524
nasopharyngeal carcinoma 13 | 1,056
ulcerative colitis 13 | 2,087
Multiple myeloma 12 | 1,327
Waldenstrons macroglobulinemia 12 | 764
acute quadriplegic myopathy 12 | 1,157
astrocytic glioma 12 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
Pick disease 11 | 1,893
atypical teratoid/rhabdoid tumor 11 | 1,095
ductal carcinoma in situ 11 | 1,745
lung carcinoma 11 | 2,844
posterior fossa group B ependymoma 11 | 1,530
primary pancreatic ductal adenocarcinoma 11 | 1,271
Atopic dermatitis 10 | 944
Endometriosis 10 | 535
adrenocortical carcinoma 10 | 1,427
astrocytoma 10 | 1,493
colon cancer 10 | 1,475
subependymal giant cell astrocytoma 10 | 2,287
Colorectal Neoplasms 9 | 217
Autistic Disorder 8 | 320
breast carcinoma 8 | 1,614
cutaneous lupus erythematosus 8 | 1,056
cystic fibrosis 8 | 1,670
diabetes mellitus 8 | 1,663
group 4 medulloblastoma 8 | 1,875
pituitary cancer 8 | 1,972
posterior fossa group A ependymoma 8 | 1,511
Epilepsy 7 | 346
Mammary Neoplasms 7 | 410
Purine nucleoside phosphorylase deficiency 7 | 11
Vascular disease 7 | 281
gastric carcinoma 7 | 832
sonic hedgehog group medulloblastoma 7 | 1,482
Lesch-Nyhan syndrome 6 | 12
Liver carcinoma 6 | 217
Stomach Neoplasms 6 | 282
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737
Adenine phosphoribosyltransferase deficiency 5 | 6
Amyotrophic Lateral Sclerosis 5 | 432
Neurodegenerative disease 5 | 383
Rheumatoid Arthritis 5 | 1,170
active Crohn's disease 5 | 918
acute myeloid leukemia 5 | 785
adult high grade glioma 5 | 2,148
juvenile dermatomyositis 5 | 1,189
mucosa-associated lymphoid tissue lymphoma 5 | 480
Anemia 4 | 252
Carcinoma 4 | 2,147
Chronic progressive external ophthalmoplegia 4 | 18
Colonic Neoplasms 4 | 126
Dihydropyrimidine dehydrogenase deficiency 4 | 6
IGA Glomerulonephritis 4 | 454
Lung Neoplasms 4 | 171
Major Depressive Disorder 4 | 106
Neoplasm Metastasis 4 | 138
Orotic aciduria 4 | 16
Osteoporosis 4 | 259
Peripheral Neuropathy 4 | 303
Reticular dysgenesis 4 | 7
Schizophrenia 4 | 503
hepatocellular carcinoma 4 | 550
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung carcinoma 4 | 413
primary Sjogren syndrome 4 | 788
Contact Dermatitis 3 | 80
Duchenne muscular dystrophy 3 | 602
Myocardial Ischemia 3 | 169
Prostatic Neoplasms 3 | 471
aldosterone-producing adenoma 3 | 664
fibroadenoma 3 | 557
nephrosclerosis 3 | 329
pancreatic carcinoma 3 | 567

Tissue

Male tissues 95 | 17,968
Blood and immune system 94 | 17,994
Endocrine System 94 | 18,511
Nervous System 94 | 18,560
Cardiovascular System 93 | 17,957
Digestive Tract 93 | 18,472
Female tissues 93 | 18,646
Liver and Pancreas 93 | 18,135
Skin and soft tissues 93 | 18,114
Urinary Tract 93 | 18,443
Respiratory system 92 | 17,483

Target Family

Enzyme 68 | 4,146
Kinase 19 | 634
Non-IDG 8 | 11,969

Reactome Pathway

Metabolism of nucleotides 95 | 95
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.60310 374.7 140
Adenylate kinase 9 AK9 Tbio Kinase -0.95667 9.15 83
Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 Tbio Enzyme -1.44872 28.8 64
CAD protein CAD Tchem Non-IDG -2.23424 164.6 201
Deoxycytidine kinase DCK Tchem Kinase -2.62238 442.5 365
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.97569 843.2 611
Thymidylate synthase TYMS Tclin Enzyme -2.92025 722.7 471
ADP-ribose pyrophosphatase, mitochondrial NUDT9 Tbio Enzyme -1.38475 20.7 110
Inosine triphosphate pyrophosphatase ITPA Tbio Enzyme -2.53294 331.9 197
Catalase CAT Tchem Enzyme -3.60189 3190.7 575