Development Level

Tbio 47 | 10,625
Tchem 31 | 1,890
Tclin 14 | 602
Tdark 3 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

embryonic lethality prior to o... 4 | 148
preweaning lethality, complete... 4 | 633
abnormal epididymis morphology 2 | 31
decreased circulating glycerol... 2 | 19
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal heart morphology 1 | 51
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal sacral vertebrae morp... 1 | 5
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased CD8-positive, naive ... 1 | 5
decreased KLRG1-positive CD4-p... 1 | 1
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased monocyte cell number 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
increased T cell number 1 | 15
increased circulating chloride... 1 | 43
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased memory CD4-positive,... 1 | 3
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 52 | 8,484
medulloblastoma, large-cell 49 | 6,234
lung cancer 45 | 4,466
psoriasis 43 | 6,685
osteosarcoma 41 | 7,933
glioblastoma 34 | 5,572
Cancer 25 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
Breast cancer 23 | 3,094
atypical teratoid / rhabdoid tumor 23 | 4,369
non-small cell lung cancer 22 | 2,798
malignant mesothelioma 21 | 3,162
tuberculosis 21 | 1,557
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
pediatric high grade glioma 19 | 2,712
primitive neuroectodermal tumor 19 | 3,031
group 3 medulloblastoma 18 | 2,254
invasive ductal carcinoma 18 | 2,950
pancreatic cancer 18 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
oligodendroglioma 17 | 2,849
ependymoma 16 | 2,514
lung adenocarcinoma 16 | 2,713
interstitial cystitis 15 | 2,299
pilocytic astrocytoma 15 | 3,086
medulloblastoma 13 | 1,524
nasopharyngeal carcinoma 13 | 1,056
ulcerative colitis 13 | 2,087
Multiple myeloma 12 | 1,327
Waldenstrons macroglobulinemia 12 | 765
acute quadriplegic myopathy 12 | 1,157
astrocytic glioma 12 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
Pick disease 11 | 1,893
atypical teratoid/rhabdoid tumor 11 | 1,095
ductal carcinoma in situ 11 | 1,745
lung carcinoma 11 | 2,844
posterior fossa group B ependymoma 11 | 1,530
primary pancreatic ductal adenocarcinoma 11 | 1,271
Atopic dermatitis 10 | 944
Endometriosis 10 | 535
adrenocortical carcinoma 10 | 1,427
astrocytoma 10 | 1,493
colon cancer 10 | 1,475
subependymal giant cell astrocytoma 10 | 2,287
Colorectal Neoplasms 9 | 217
Autistic Disorder 8 | 320
breast carcinoma 8 | 1,614
cutaneous lupus erythematosus 8 | 1,056
cystic fibrosis 8 | 1,665
diabetes mellitus 8 | 1,663
group 4 medulloblastoma 8 | 1,875
pituitary cancer 8 | 1,972
posterior fossa group A ependymoma 8 | 1,511
Epilepsy 7 | 346
Mammary Neoplasms 7 | 410
Purine nucleoside phosphorylase deficiency 7 | 11
Vascular disease 7 | 281
gastric carcinoma 7 | 832
sonic hedgehog group medulloblastoma 7 | 1,482
Lesch-Nyhan syndrome 6 | 12
Liver carcinoma 6 | 217
Stomach Neoplasms 6 | 282
dermatomyositis 6 | 933
esophageal adenocarcinoma 6 | 737
Adenine phosphoribosyltransferase deficiency 5 | 6
Amyotrophic Lateral Sclerosis 5 | 431
Neurodegenerative disease 5 | 383
Rheumatoid Arthritis 5 | 1,160
active Crohn's disease 5 | 918
acute myeloid leukemia 5 | 780
adult high grade glioma 5 | 2,148
juvenile dermatomyositis 5 | 1,189
mucosa-associated lymphoid tissue lymphoma 5 | 480
Anemia 4 | 252
Carcinoma 4 | 2,147
Chronic progressive external ophthalmoplegia 4 | 18
Colonic Neoplasms 4 | 126
Dihydropyrimidine Dehydrogenase Deficiency 4 | 6
IGA Glomerulonephritis 4 | 454
Lung Neoplasms 4 | 171
Major Depressive Disorder 4 | 106
Neoplasm Metastasis 4 | 138
Orotic aciduria 4 | 16
Osteoporosis 4 | 257
Peripheral Neuropathy 4 | 303
Reticular dysgenesis 4 | 7
Schizophrenia 4 | 501
hepatocellular carcinoma 4 | 532
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung carcinoma 4 | 413
primary Sjogren syndrome 4 | 789
Contact Dermatitis 3 | 80
Duchenne muscular dystrophy 3 | 602
Myocardial Ischemia 3 | 169
Prostatic Neoplasms 3 | 471
aldosterone-producing adenoma 3 | 664
fibroadenoma 3 | 557
nephrosclerosis 3 | 329
pancreatic carcinoma 3 | 567

Tissue

Male tissues 95 | 17,969
Blood and immune system 94 | 17,995
Endocrine System 94 | 18,512
Nervous System 94 | 18,561
Cardiovascular System 93 | 17,958
Digestive Tract 93 | 18,473
Female tissues 93 | 18,647
Liver and Pancreas 93 | 18,136
Skin and soft tissues 93 | 18,115
Urinary Tract 93 | 18,444
Respiratory system 92 | 17,484

Target Family

Enzyme 68 | 4,146
Kinase 19 | 634
Non-IDG 8 | 11,971

Reactome Pathway

Metabolism of nucleotides 95 | 95
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Phosphoribosylformylglycinamidine synthase PFAS Tbio Enzyme -2.68616 520.0 75
Ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 Tbio Enzyme -2.59508 482.4 411
Pseudouridine-5'-phosphatase PUDP Tdark Enzyme 0.30 0.93 73
GMP synthase [glutamine-hydrolyzing] GMPS Tchem Enzyme -2.43758 281.7 169
Cytosolic purine 5'-nucleotidase NT5C2 Tchem Enzyme -2.20716 156.4 131
7,8-dihydro-8-oxoguanine triphosphatase NUDT1 Tchem Enzyme -2.22783 223.6 143
8-oxo-dGDP phosphatase NUDT18 NUDT18 Tbio Enzyme 0.00000 1.44 67
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP Tbio Enzyme -0.95155 9.47 64
Glutathione reductase, mitochondrial GSR Tclin Enzyme -2.97339 830.6 224