Development Level

Tbio 58 | 11,445
Tchem 22 | 1,598
Tclin 15 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 5 | 239
preweaning lethality, incomple... 4 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryonic autopod pla... 1 | 2
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal placenta morphology 1 | 5
abnormal retinal vasculature m... 1 | 27
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
thin ventricular wall 1 | 24
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

ovarian cancer 55 | 8,520
medulloblastoma, large-cell 51 | 6,241
Carcinoma 50 | 11,493
lung cancer 47 | 4,740
psoriasis 44 | 6,694
osteosarcoma 43 | 7,950
glioblastoma 36 | 5,792
group 3 medulloblastoma 35 | 4,104
ependymoma 31 | 4,679
atypical teratoid / rhabdoid tumor 30 | 5,112
Autosomal recessive predisposition 27 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
Cancer 25 | 2,499
Breast cancer 24 | 3,578
tuberculosis 23 | 2,010
non-small cell lung cancer 22 | 2,890
primitive neuroectodermal tumor 21 | 3,035
malignant mesothelioma 20 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
oligodendroglioma 19 | 2,850
pancreatic cancer 18 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Astrocytoma, Pilocytic 17 | 3,081
invasive ductal carcinoma 17 | 2,951
interstitial cystitis 16 | 2,312
Epilepsy 15 | 792
adult high grade glioma 15 | 3,801
lung adenocarcinoma 15 | 2,716
Pick disease 14 | 1,894
Multiple myeloma 13 | 1,332
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
acute quadriplegic myopathy 12 | 1,158
nasopharyngeal carcinoma 12 | 1,058
pediatric high grade glioma 12 | 1,064
primary pancreatic ductal adenocarcinoma 12 | 1,109
Muscle hypotonia 11 | 571
Seizures 11 | 596
Waldenstrons macroglobulinemia 11 | 765
colon cancer 11 | 1,478
ductal carcinoma in situ 11 | 1,745
lung carcinoma 11 | 2,843
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 1,819
Endometriosis 10 | 540
Intellectual disability 10 | 1,016
astrocytoma 10 | 1,146
Anemia 9 | 365
Atopic dermatitis 9 | 952
Colorectal Neoplasms 9 | 243
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
cutaneous lupus erythematosus 9 | 1,057
cystic fibrosis 9 | 1,696
diabetes mellitus 9 | 1,728
Vascular disease 8 | 319
group 4 medulloblastoma 8 | 1,855
pituitary cancer 8 | 1,972
Adenocarcinoma of lung 7 | 142
Cognitive delay 7 | 608
Disease Models, Animal 7 | 155
Failure to gain weight 7 | 365
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Pediatric failure to thrive 7 | 365
breast carcinoma 7 | 1,638
gastric carcinoma 7 | 807
Breast Neoplasms 6 | 445
Carcinoma, Hepatocellular 6 | 228
Cerebral atrophy 6 | 178
Infantile onset 6 | 238
Kidney cancer 6 | 2,613
Liver carcinoma 6 | 240
Mammary Neoplasms 6 | 425
Obesity 6 | 678
Purine nucleoside phosphorylase deficiency 6 | 11
Stomach Neoplasms 6 | 300
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737
juvenile dermatomyositis 6 | 1,187
Amyotrophic lateral sclerosis 5 | 451
Autistic Disorder 5 | 364
Degenerative brain disorder 5 | 100
Mental Depression 5 | 333
Neurodegenerative disease 5 | 414
Nystagmus 5 | 317
Optic Atrophy 5 | 242
Orotic aciduria 5 | 18
Rheumatoid arthritis 5 | 1,191
Supratentorial atrophy 5 | 94
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
atypical teratoid/rhabdoid tumor 5 | 357
mucosa-associated lymphoid tissue lymphoma 5 | 484
primary Sjogren syndrome 5 | 735

Tissue

Digestive Tract 99 | 17,369
Female tissues 99 | 17,400
Liver and Pancreas 99 | 16,750
Skin and soft tissues 99 | 17,230
Urinary Tract 99 | 16,678
Endocrine System 98 | 18,159
Male tissues 98 | 17,142
Blood and immune system 97 | 16,909
Respiratory system 97 | 16,393
Nervous System 96 | 16,725
Cardiovascular System 93 | 15,192

Target Family

Enzyme 69 | 4,145
Kinase 23 | 634
Non-IDG 8 | 12,091

Reactome Pathway

Metabolism of nucleotides 100 | 100
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Uridine-cytidine kinase-like 1 UCKL1 Tdark Kinase -0.15970 2.21 110
Adenylate kinase isoenzyme 5 AK5 Tbio Kinase -1.83209 76.0 225
CTP synthase 1 CTPS1 Tbio Enzyme -2.29349 196.5 107
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150
Nucleotide triphosphate diphosphatase NUDT15 NUDT15 Tbio Enzyme -1.60299 37.9 77
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Cytosolic 5'-nucleotidase 1B NT5C1B Tbio Enzyme -1.94015 85.4 93
Adenylate kinase isoenzyme 6 AK6 Tbio Kinase -2.18859 223.1 91
AMP deaminase 2 AMPD2 Tchem Enzyme -1.74341 53.6 155