Development Level

Tbio 43 | 11,651
Tdark 7 | 6,593

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal heart morphology 1 | 162
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210

Disease

Carcinoma 35 | 11,493
group 3 medulloblastoma 30 | 4,104
lung cancer 30 | 4,740
ovarian cancer 30 | 8,520
osteosarcoma 25 | 7,950
medulloblastoma, large-cell 22 | 6,241
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 16 | 5,792
psoriasis 14 | 6,694
dermatomyositis 13 | 966
malignant mesothelioma 12 | 3,232
non-small cell lung cancer 12 | 2,890
primitive neuroectodermal tumor 12 | 3,035
Breast cancer 11 | 3,578
Multiple myeloma 11 | 1,332
Kidney cancer 10 | 2,613
Muscular atrophy 10 | 71
Waldenstrons macroglobulinemia 9 | 765
adult high grade glioma 9 | 3,801
ependymoma 9 | 4,679
oligodendroglioma 9 | 2,850
acute quadriplegic myopathy 7 | 1,158
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
colon cancer 6 | 1,478
Astrocytoma, Pilocytic 5 | 3,081
Pick disease 5 | 1,894
Spinal muscular atrophy 5 | 34
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
invasive ductal carcinoma 5 | 2,951
pediatric high grade glioma 5 | 1,064
acute myeloid leukemia 4 | 783
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
astrocytoma 3 | 1,146
atypical teratoid/rhabdoid tumor 3 | 357
lung adenocarcinoma 3 | 2,716
sonic hedgehog group medulloblastoma 3 | 467
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Dull intelligence 2 | 645
Epilepsy 2 | 792
Galloway-Mowat syndrome 2 | 15
HIV Infections 2 | 102
Intellectual disability 2 | 1,016
Leukemia 2 | 104
Leukemia, Myelocytic, Acute 2 | 120
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE 2 | 4
Nephrotic syndrome, idiopathic, steroid-resistant 2 | 4
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
adrenocortical carcinoma 2 | 1,428
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
interstitial lung disease 2 | 298
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
posterior fossa group B ependymoma 2 | 416
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 1 | 21
Agoraphobia 1 | 21
Autosomal recessive hypohidrotic ectodermal dysplasia syndrome 1 | 3
Cavernous hemangioma 1 | 11
Cystic kidney 1 | 30
Deglutition Disorders 1 | 132
Dental abnormalities 1 | 60
Dentin sensitivity 1 | 14
Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant 1 | 3
Hypohidrotic ectodermal dysplasia 1 | 15
Irritable bowel syndrome 1 | 60
Leukemia, Acute Myeloid 1 | 17
Leukemia, Myeloid, Acute 1 | 105
Mixed connective tissue disease 1 | 16
Nail disease 1 | 9
Osteitis Deformans 1 | 11
Paget's disease of bone 1 | 36
Papillary thyroid carcinoma 1 | 43
Renal cyst 1 | 30
Sparse body hair 1 | 32
Spinocerebellar ataxia type 1 1 | 16
Striatonigral Degeneration, Infantile 1 | 4
Thyroid Neoplasm 1 | 37
Thyroid Neoplasms 1 | 34
Tooth Abnormalities 1 | 69
triple-A syndrome 1 | 17

Tissue

Blood and immune system 49 | 16,909
Cardiovascular System 49 | 15,192
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678

Target Family

Non-IDG 45 | 12,091
Enzyme 4 | 4,145
Epigenetic 1 | 242

Reactome Pathway

Metabolism of non-coding RNA 50 | 50
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear pore complex protein Nup50 NUP50 Tbio Non-IDG -1.18445 15.9 270
Gem-associated protein 6 GEMIN6 Tbio Non-IDG -1.28961 17.2 110
Gem-associated protein 8 GEMIN8 Tdark Non-IDG -0.23075 2.19 96
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.34134 207.7 172
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.69756 4.39 42
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.80390 62.5 241
Probable ATP-dependent RNA helicase DDX20 DDX20 Tbio Enzyme -1.58249 38.0 250
Nuclear pore complex protein Nup133 NUP133 Tbio Non-IDG -1.36479 22.8 72
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46