Development Level

Tbio 479 | 10,625
Tchem 211 | 1,890
Tdark 72 | 7,003
Tclin 35 | 602

Collection

Eligible Kinase Proteins 11 | 134

IMPC Term

preweaning lethality, complete... 41 | 633
preweaning lethality, incomple... 18 | 260
embryonic lethality prior to t... 14 | 187
decreased total body fat amoun... 13 | 186
abnormal behavior 11 | 226
abnormal embryo size 11 | 112
decreased body weight 11 | 174
decreased circulating glucose ... 11 | 121
embryonic lethality prior to o... 11 | 148
abnormal retina morphology 9 | 100
increased circulating alkaline... 9 | 119
abnormal bone structure 8 | 131
abnormal lens morphology 8 | 73
decreased lean body mass 8 | 195
increased mean corpuscular hem... 8 | 93
abnormal retinal pigmentation 6 | 61
decreased bone mineral content 6 | 157
decreased circulating HDL chol... 6 | 77
hypoactivity 6 | 89
increased circulating choleste... 6 | 53
increased circulating sodium l... 6 | 71
increased lean body mass 6 | 107
abnormal coat appearance 5 | 25
abnormal neural tube closure 5 | 37
abnormal sleep behavior 5 | 63
decreased body length 5 | 108
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
decreased grip strength 5 | 123
enlarged heart 5 | 111
hyperactivity 5 | 108
increased body weight 5 | 42
increased bone mineral content 5 | 92
increased or absent threshold ... 5 | 128
decreased Ly6C low monocyte nu... 4 | 23
decreased bone mineral density 4 | 126
decreased circulating alkaline... 4 | 41
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased mean corpuscular vol... 4 | 50
embryonic growth retardation 4 | 28
impaired glucose tolerance 4 | 52
increased bone mineral density 4 | 52
increased circulating HDL chol... 4 | 63
increased fasted circulating g... 4 | 68
increased total body fat amoun... 4 | 57
persistence of hyaloid vascula... 4 | 22
small testis 4 | 37
thrombocytopenia 4 | 46
abnormal embryo turning 3 | 15
abnormal epididymis morphology 3 | 31
abnormal heart morphology 3 | 51
abnormal tail bud morphology 3 | 6
abnormal testis morphology 3 | 30
abnormal tooth morphology 3 | 24
decreased NK T cell number 3 | 28
decreased circulating calcium ... 3 | 33
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased eosinophil cell numb... 3 | 41
decreased fasted circulating g... 3 | 49
decreased neutrophil cell numb... 3 | 37
enlarged epididymis 3 | 27
enlarged spleen 3 | 26
improved glucose tolerance 3 | 56
increased Ly6C high monocyte n... 3 | 12
increased circulating bilirubi... 3 | 16
increased circulating free fat... 3 | 17
increased circulating iron lev... 3 | 25
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased exploration in new e... 3 | 56
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
abnormal behavioral response t... 2 | 52
abnormal body wall morphology 2 | 7
abnormal respiratory quotient 2 | 9
abnormal spleen morphology 2 | 36
cardiovascular system phenotyp... 2 | 35
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased rib number 2 | 59
decreased vertical activity 2 | 22
increased circulating aspartat... 2 | 17
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased heart weight 2 | 37
increased mean platelet volume 2 | 19
short tibia 2 | 82
thrombocytosis 2 | 23
tremors 2 | 34

Disease

ovarian cancer 418 | 8,484
osteosarcoma 364 | 7,933
psoriasis 350 | 6,685
medulloblastoma, large-cell 279 | 6,234
glioblastoma 242 | 5,572
lung cancer 214 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 208 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 187 | 2,956
atypical teratoid / rhabdoid tumor 186 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 175 | 1,795
intraductal papillary-mucinous carcinoma (IPMC) 173 | 2,988
malignant mesothelioma 172 | 3,162
invasive ductal carcinoma 165 | 2,950
lung carcinoma 142 | 2,844
Breast cancer 140 | 3,094
interstitial cystitis 138 | 2,299
ulcerative colitis 137 | 2,087
oligodendroglioma 135 | 2,849
pilocytic astrocytoma 134 | 3,086
non-small cell lung cancer 132 | 2,798
pancreatic cancer 131 | 2,300
lung adenocarcinoma 128 | 2,713
subependymal giant cell astrocytoma 120 | 2,287
pediatric high grade glioma 119 | 2,712
diabetes mellitus 115 | 1,663
Cancer 113 | 2,346
ductal carcinoma in situ 113 | 1,745
ependymoma 113 | 2,514
primitive neuroectodermal tumor 109 | 3,031
group 4 medulloblastoma 105 | 1,875
pituitary cancer 103 | 1,972
Pick disease 97 | 1,893
astrocytoma 95 | 1,493
tuberculosis 95 | 1,557
adrenocortical carcinoma 94 | 1,427
astrocytic glioma 93 | 2,241
Obesity 89 | 616
adult high grade glioma 88 | 2,148
cystic fibrosis 87 | 1,665
active Crohn's disease 78 | 918
breast carcinoma 78 | 1,614
group 3 medulloblastoma 77 | 2,254
colon cancer 75 | 1,475
acute quadriplegic myopathy 69 | 1,157
posterior fossa group A ependymoma 69 | 1,511
Rheumatoid Arthritis 67 | 1,160
Carcinoma 66 | 2,147
posterior fossa group B ependymoma 65 | 1,530
primary pancreatic ductal adenocarcinoma 65 | 1,271
Multiple myeloma 63 | 1,327
Atopic dermatitis 62 | 944
Atherosclerosis 61 | 275
spina bifida 60 | 1,064
juvenile dermatomyositis 56 | 1,189
medulloblastoma 56 | 1,524
esophageal adenocarcinoma 50 | 737
sonic hedgehog group medulloblastoma 50 | 1,482
Waldenstrons macroglobulinemia 49 | 765
dermatomyositis 49 | 933
cutaneous lupus erythematosus 48 | 1,056
Coronary artery disease 47 | 240
Lipid metabolism disorder 47 | 102
nasopharyngeal carcinoma 47 | 1,056
Prostatic Neoplasms 46 | 471
gastric carcinoma 46 | 832
aldosterone-producing adenoma 44 | 664
atypical teratoid/rhabdoid tumor 44 | 1,095
non primary Sjogren syndrome sicca 44 | 840
Metabolic syndrome X 43 | 155
Alzheimer's disease 41 | 644
acute myeloid leukemia 40 | 780
Peripheral Neuropathy 37 | 303
pancreatic carcinoma 37 | 567
primary Sjogren syndrome 37 | 789
fibroadenoma 36 | 557
Intellectual disability 35 | 573
Neurodegenerative disease 35 | 383
Down syndrome 34 | 548
Mammary Neoplasms 34 | 410
active ulcerative colitis 33 | 477
progressive supranuclear palsy 33 | 674
Fatty liver disease 32 | 84
Liver carcinoma 32 | 217
Duchenne muscular dystrophy 31 | 602
Liver disease 31 | 219
nephrosclerosis 31 | 329
Amyotrophic Lateral Sclerosis 30 | 431
Hypertension 30 | 287
Kidney disease 30 | 396
tuberculosis and treatment for 6 months 30 | 686
Cerebrovascular disease 29 | 231
Endometriosis 29 | 535
Polycystic Ovary Syndrome 29 | 332
IGA Glomerulonephritis 28 | 454
Cardiovascular system disease 27 | 194
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 499
Heart disease 26 | 279
Cholestasis 25 | 93
chronic rhinosinusitis 24 | 512
mucosa-associated lymphoid tissue lymphoma 24 | 480

Tissue

Digestive Tract 790 | 18,473
Liver and Pancreas 788 | 18,136
Nervous System 788 | 18,561
Urinary Tract 788 | 18,444
Female tissues 786 | 18,647
Endocrine System 785 | 18,512
Skin and soft tissues 783 | 18,115
Blood and immune system 781 | 17,995
Cardiovascular System 781 | 17,958
Male tissues 779 | 17,969
Respiratory system 772 | 17,484

Target Family

Enzyme 478 | 4,146
Non-IDG 199 | 11,971
Kinase 48 | 634
Transcription Factor 27 | 1,400
Transporter 26 | 473
Nuclear Receptor 10 | 48
Epigenetic 8 | 242
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism of lipids and lipop... 797 | 797
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.85387 67.6 146
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Sialidase-3 NEU3 Tbio Enzyme -1.97558 109.4 23
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Ileal sodium/bile acid cotransporter SLC10A2 Tchem Transporter -2.60727 417.5 121
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641