Development Level

Tbio 490 | 11,651
Tchem 155 | 1,388
Tdark 59 | 6,593
Tclin 35 | 612

Collection

Kinase: IDG Consortium (Target... 10 | 125
RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 48 | 979
preweaning lethality, incomple... 31 | 499
decreased total body fat amoun... 15 | 207
embryonic lethality prior to t... 15 | 278
abnormal behavior 14 | 298
abnormal embryo size 14 | 220
abnormal heart morphology 13 | 162
embryonic lethality prior to o... 13 | 239
decreased vertical activity 12 | 208
cataract 11 | 92
decreased circulating glucose ... 11 | 126
enlarged heart 11 | 210
abnormal lens morphology 10 | 81
decreased body weight 10 | 161
abnormal bone structure 9 | 187
decreased bone mineral content 9 | 151
embryonic growth retardation 9 | 106
increased lean body mass 9 | 172
decreased circulating HDL chol... 8 | 68
decreased circulating choleste... 8 | 93
increased mean corpuscular hem... 8 | 96
abnormal retina morphology 7 | 71
decreased bone mineral density 7 | 126
hypoactivity 7 | 132
increased circulating alkaline... 7 | 122
increased startle reflex 7 | 112
decreased circulating triglyce... 6 | 79
decreased grip strength 6 | 116
decreased mean corpuscular vol... 6 | 79
hyperactivity 6 | 148
increased bone mineral content 6 | 108
increased bone mineral density 6 | 72
increased total body fat amoun... 6 | 134
abnormal neural tube closure 5 | 46
abnormal seminal vesicle morph... 5 | 114
abnormal testis morphology 5 | 43
decreased body length 5 | 101
decreased circulating alanine ... 5 | 47
hydrometra 5 | 53
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased mean platelet volume 5 | 45
increased or absent threshold ... 5 | 101
male infertility 5 | 123
abnormal epididymis morphology 4 | 42
abnormal sleep behavior 4 | 70
abnormal spleen morphology 4 | 55
anophthalmia 4 | 33
decreased circulating calcium ... 4 | 36
decreased circulating serum al... 4 | 82
decreased fasted circulating g... 4 | 65
decreased heart weight 4 | 27
decreased lean body mass 4 | 135
decreased leukocyte cell numbe... 4 | 73
enlarged epididymis 4 | 31
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased body length 4 | 32
increased circulating HDL chol... 4 | 80
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
increased mean corpuscular vol... 4 | 92
increased monocyte cell number 4 | 63
microphthalmia 4 | 26
persistence of hyaloid vascula... 4 | 33
small testis 4 | 58
thrombocytopenia 4 | 56
abnormal coat appearance 3 | 31
abnormal embryo turning 3 | 31
abnormal eye morphology 3 | 68
abnormal joint morphology 3 | 23
abnormal tibia morphology 3 | 14
decreased circulating LDL chol... 3 | 38
decreased circulating aspartat... 3 | 34
decreased circulating creatini... 3 | 39
decreased circulating iron lev... 3 | 32
decreased circulating phosphat... 3 | 27
decreased circulating total pr... 3 | 49
decreased mean corpuscular hem... 3 | 50
decreased mean platelet volume 3 | 25
decreased neutrophil cell numb... 3 | 42
increased body weight 3 | 25
increased circulating amylase ... 3 | 25
increased circulating bilirubi... 3 | 16
increased circulating phosphat... 3 | 26
increased grip strength 3 | 41
increased heart rate 3 | 23
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
thin ventricular wall 3 | 24
abnormal vertebrae morphology 2 | 18
decreased circulating insulin ... 2 | 76
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
increased anti-nuclear antigen... 2 | 19
increased circulating potassiu... 2 | 29
increased hemoglobin content 2 | 45
thrombocytosis 2 | 27

Disease

Carcinoma 490 | 11,493
ovarian cancer 389 | 8,520
osteosarcoma 344 | 7,950
psoriasis 330 | 6,694
medulloblastoma, large-cell 267 | 6,241
glioblastoma 233 | 5,792
lung cancer 204 | 4,740
atypical teratoid / rhabdoid tumor 201 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 184 | 3,291
ependymoma 182 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 168 | 2,955
malignant mesothelioma 165 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 165 | 1,962
group 3 medulloblastoma 150 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 149 | 2,989
invasive ductal carcinoma 147 | 2,951
adult high grade glioma 144 | 3,801
Breast cancer 141 | 3,578
lung carcinoma 129 | 2,843
non-small cell lung cancer 126 | 2,890
interstitial cystitis 123 | 2,312
oligodendroglioma 123 | 2,850
Astrocytoma, Pilocytic 121 | 3,081
Autosomal recessive predisposition 119 | 1,442
Cancer 119 | 2,499
lung adenocarcinoma 118 | 2,716
pancreatic cancer 116 | 2,398
tuberculosis 110 | 2,010
subependymal giant cell astrocytoma 108 | 2,287
diabetes mellitus 103 | 1,728
Kidney cancer 102 | 2,613
primitive neuroectodermal tumor 102 | 3,035
astrocytic glioma 101 | 2,597
ulcerative colitis 100 | 1,819
ductal carcinoma in situ 99 | 1,745
Pick disease 97 | 1,894
pituitary cancer 92 | 1,972
group 4 medulloblastoma 86 | 1,855
Obesity 83 | 678
cystic fibrosis 82 | 1,696
adrenocortical carcinoma 79 | 1,428
Schizophrenia 74 | 1,160
astrocytoma 71 | 1,146
colon cancer 71 | 1,478
active Crohn's disease 69 | 922
breast carcinoma 67 | 1,638
Intellectual disability 65 | 1,016
Rheumatoid arthritis 65 | 1,191
acute quadriplegic myopathy 63 | 1,158
Liver Cirrhosis, Experimental 62 | 769
Multiple myeloma 59 | 1,332
Atopic dermatitis 58 | 952
Epilepsy 58 | 792
active ulcerative colitis 57 | 764
Muscle hypotonia 54 | 571
Seizures 54 | 596
primary pancreatic ductal adenocarcinoma 54 | 1,109
juvenile dermatomyositis 52 | 1,187
spina bifida 50 | 1,074
Prostatic Neoplasms 49 | 495
Dull intelligence 48 | 645
Low intelligence 48 | 645
Mental Retardation 48 | 645
Mental deficiency 48 | 645
Poor school performance 48 | 645
Waldenstrons macroglobulinemia 48 | 765
cutaneous lupus erythematosus 48 | 1,057
pediatric high grade glioma 47 | 1,064
Hepatomegaly 46 | 285
aldosterone-producing adenoma 46 | 665
dermatomyositis 46 | 966
Bipolar Disorder 43 | 666
Cognitive delay 43 | 608
Failure to gain weight 43 | 365
Global developmental delay 43 | 608
Mental and motor retardation 43 | 608
Pediatric failure to thrive 43 | 365
esophageal adenocarcinoma 43 | 737
non primary Sjogren syndrome sicca 42 | 891
Breast Neoplasms 41 | 445
nasopharyngeal carcinoma 41 | 1,058
Mammary Neoplasms 40 | 425
Short stature 40 | 531
gastric carcinoma 37 | 807
acute myeloid leukemia 36 | 783
Alzheimer's disease 35 | 658
Atherosclerosis 35 | 291
Hypertension 35 | 396
Cholestasis 34 | 155
Depressive disorder 34 | 409
Neurodegenerative disease 34 | 414
progressive supranuclear palsy 34 | 676
Fatty liver disease 33 | 103
Liver carcinoma 33 | 240
pancreatic carcinoma 33 | 562
primary Sjogren syndrome 33 | 735
Carcinoma, Hepatocellular 32 | 228
Chemical and Drug Induced Liver Injury 31 | 195
Osteoporosis 31 | 363
nephrosclerosis 31 | 333

Tissue

Digestive Tract 723 | 17,369
Endocrine System 721 | 18,159
Female tissues 721 | 17,400
Skin and soft tissues 720 | 17,230
Male tissues 714 | 17,142
Liver and Pancreas 712 | 16,750
Urinary Tract 708 | 16,678
Blood and immune system 703 | 16,909
Nervous System 696 | 16,725
Respiratory system 689 | 16,393
Cardiovascular System 652 | 15,192

Target Family

Enzyme 448 | 4,145
Non-IDG 176 | 12,091
Kinase 47 | 634
Transporter 24 | 473
Transcription Factor 23 | 1,400
Nuclear Receptor 12 | 48
Epigenetic 8 | 242
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism of lipids 739 | 739
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Fatty-acid amide hydrolase 2 FAAH2 Tbio Enzyme -0.82593 5.68 104
Ethanolaminephosphotransferase 1 SELENOI Tbio Enzyme -2.01142 98.3 12
Fat storage-inducing transmembrane protein 2 FITM2 Tdark Non-IDG -1.27967 17.3 2
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Tbio Enzyme -2.67168 459.1 229
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126