Development Level

Tbio 9 | 11,445
Tchem 5 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to o... 2 | 239
abnormal allantois morphology 1 | 8
abnormal coat appearance 1 | 31
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 10 | 11,493
ovarian cancer 10 | 8,520
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
non-small cell lung cancer 8 | 2,890
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
Breast cancer 6 | 3,578
Cancer 5 | 2,499
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Adverse reaction to drug 4 | 61
Cleft Lip 4 | 141
Cleft Palate 4 | 271
Colorectal Neoplasms 4 | 243
Drug-Related Side Effects and Adverse Reactions 4 | 62
Malignant mesothelioma of pleura 4 | 7
Nervous System Diseases 4 | 53
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
lung cancer 4 | 4,740
nasopharyngeal carcinoma 4 | 1,058
nervous system disorder 4 | 53
pancreatic cancer 4 | 2,398
tuberculosis 4 | 2,010
Acute lymphoid leukemia 3 | 25
Arthritis, Rheumatoid 3 | 174
Autistic Disorder 3 | 364
Breast Neoplasms 3 | 445
Burkitt's lymphoma 3 | 15
Carcinoma of female breast 3 | 20
Gestational trophoblastic neoplasia 3 | 14
Hyperhomocysteinemia 3 | 37
Juvenile rheumatoid arthritis 3 | 111
Liver Cirrhosis, Experimental 3 | 769
Lymphoma, Non-Hodgkin 3 | 24
Malignant tumor of head and/or neck 3 | 15
Malignant tumor of lung 3 | 5
Mammary Neoplasms 3 | 425
Meningeal Leukemia 3 | 7
Mycosis fungoides 3 | 29
Neural Tube Defects 3 | 31
Non-Hodgkin's lymphoma 3 | 22
Osteosarcoma of bone 3 | 6
Precursor Cell Lymphoblastic Leukemia Lymphoma 3 | 43
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 | 49
Schizophrenia 3 | 1,160
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
biotin-responsive basal ganglia disease 3 | 8
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
neural tube defect 3 | 9
oligodendroglioma 3 | 2,850
pancreatic carcinoma 3 | 562
spina bifida 3 | 1,074
Adenocarcinoma of lung 2 | 142
Alcoholic Intoxication, Chronic 2 | 289
Alzheimer's disease 2 | 658
Anemia 2 | 365
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Bladder Neoplasm 2 | 112
Cognitive delay 2 | 608
Colonic Neoplasms 2 | 142
Congenital heart disease 2 | 93
Disease Models, Animal 2 | 155
Down syndrome 2 | 499
Female infertility 2 | 30
Global developmental delay 2 | 608
Homocystinuria 2 | 21
Kidney cancer 2 | 2,613
Malaria 2 | 160
Megaloblastic anemia 2 | 18
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Neoplasm Metastasis 2 | 168
Pancytopenia 2 | 45
Polycystic ovary syndrome 2 | 360
Urinary Bladder Neoplasms 2 | 114
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 12 | 4,145
Transporter 3 | 473
Non-IDG 1 | 12,091

Reactome Pathway

Metabolism of folate and pteri... 16 | 16
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
Folate transporter 1 SLC19A1 Tchem Transporter -2.00363 97.7 67
Folate receptor beta FOLR2 Tchem Non-IDG -1.91119 88.6 222
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Folylpolyglutamate synthase, mitochondrial FPGS Tchem Enzyme -1.90018 79.8 131
Dihydrofolate reductase 2, mitochondrial DHFR2 Tbio Enzyme -0.37414 2.93 82
5-formyltetrahydrofolate cyclo-ligase MTHFS Tbio Enzyme -1.10094 12.8 167
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.43089 24.9 131