Development Level

Tbio 281 | 11,445
Tchem 52 | 1,598
Tdark 19 | 6,588
Tclin 18 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 20 | 979
abnormal behavior 7 | 298
decreased total body fat amoun... 7 | 207
preweaning lethality, incomple... 7 | 499
decreased vertical activity 5 | 208
increased bone mineral content 5 | 108
increased lean body mass 5 | 172
decreased bone mineral density 4 | 126
decreased circulating alkaline... 4 | 46
decreased grip strength 4 | 116
embryonic lethality prior to o... 4 | 239
hyperactivity 4 | 148
hypoactivity 4 | 132
male infertility 4 | 123
abnormal craniofacial morpholo... 3 | 33
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating potassiu... 3 | 20
decreased fasted circulating g... 3 | 65
decreased leukocyte cell numbe... 3 | 73
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
enlarged heart 3 | 210
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
cataract 2 | 92
decreased circulating bilirubi... 2 | 19
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased food intake 2 | 13
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
microphthalmia 2 | 26
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal sensory capabilities-... 1 | 8
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
enlarged epididymis 1 | 31
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thin ventricular wall 1 | 24

Disease

Carcinoma 178 | 11,493
ovarian cancer 170 | 8,520
psoriasis 128 | 6,694
lung cancer 123 | 4,740
osteosarcoma 121 | 7,950
medulloblastoma, large-cell 107 | 6,241
Autosomal recessive predisposition 86 | 1,442
glioblastoma 84 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 80 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 79 | 1,962
Multiple myeloma 74 | 1,332
atypical teratoid / rhabdoid tumor 70 | 5,112
ependymoma 64 | 4,679
group 3 medulloblastoma 60 | 4,104
Breast cancer 57 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,989
invasive ductal carcinoma 56 | 2,951
adult high grade glioma 54 | 3,801
malignant mesothelioma 54 | 3,232
Intellectual disability 53 | 1,016
Epilepsy 52 | 792
Cognitive delay 51 | 608
Global developmental delay 51 | 608
Mental and motor retardation 51 | 608
non-small cell lung cancer 49 | 2,890
lung adenocarcinoma 48 | 2,716
oligodendroglioma 48 | 2,850
Cancer 47 | 2,499
Seizures 46 | 596
diabetes mellitus 45 | 1,728
Astrocytoma, Pilocytic 44 | 3,081
interstitial cystitis 44 | 2,312
lung carcinoma 44 | 2,843
primitive neuroectodermal tumor 44 | 3,035
Dull intelligence 43 | 645
Low intelligence 43 | 645
Mental Retardation 43 | 645
Mental deficiency 43 | 645
Poor school performance 43 | 645
Muscle hypotonia 41 | 571
pancreatic cancer 40 | 2,398
subependymal giant cell astrocytoma 37 | 2,287
Liver Cirrhosis, Experimental 35 | 769
cystic fibrosis 35 | 1,696
astrocytic glioma 34 | 2,597
Waldenstrons macroglobulinemia 33 | 765
tuberculosis 32 | 2,010
ulcerative colitis 32 | 1,819
Pick disease 31 | 1,894
Schizophrenia 30 | 1,160
pituitary cancer 30 | 1,972
adrenocortical carcinoma 27 | 1,428
astrocytoma 27 | 1,146
cutaneous lupus erythematosus 27 | 1,057
ductal carcinoma in situ 27 | 1,745
Diamond-Blackfan anemia 25 | 31
acute quadriplegic myopathy 25 | 1,158
colon cancer 25 | 1,478
dermatomyositis 25 | 966
Anemia 23 | 365
Failure to gain weight 23 | 365
Infantile onset 23 | 238
Pediatric failure to thrive 23 | 365
nephrosclerosis 23 | 333
Small head 22 | 374
Bipolar Disorder 21 | 666
Cleft Palate 20 | 271
breast carcinoma 20 | 1,638
gastric carcinoma 20 | 807
sonic hedgehog group medulloblastoma 20 | 467
esophageal adenocarcinoma 19 | 737
Fatigue 18 | 182
Kidney cancer 18 | 2,613
Lethargy 18 | 77
active Crohn's disease 18 | 922
acute myeloid leukemia 18 | 783
Prostatic Neoplasms 17 | 495
juvenile dermatomyositis 17 | 1,187
non primary Sjogren syndrome sicca 17 | 891
primary Sjogren syndrome 17 | 735
Cerebellar Ataxia 16 | 304
HIV Infections 16 | 102
Hyperreflexia 16 | 209
Maple syrup urine disease 16 | 24
Uranostaphyloschisis 16 | 167
group 4 medulloblastoma 16 | 1,855
Dystonia 15 | 164
active ulcerative colitis 15 | 764
aldosterone-producing adenoma 15 | 665
medulloblastoma 15 | 720
pediatric high grade glioma 15 | 1,064
progressive supranuclear palsy 15 | 676
Adenocarcinoma of lung 14 | 142
Anemia, Macrocytic 14 | 18
Atopic dermatitis 14 | 952
Depressive disorder 14 | 409
Melanoma 14 | 711
Vomiting 14 | 116
spina bifida 14 | 1,074

Tissue

Endocrine System 364 | 18,159
Female tissues 358 | 17,400
Digestive Tract 357 | 17,369
Nervous System 356 | 16,725
Blood and immune system 355 | 16,909
Urinary Tract 355 | 16,678
Liver and Pancreas 354 | 16,750
Skin and soft tissues 354 | 17,230
Male tissues 350 | 17,142
Respiratory system 345 | 16,393
Cardiovascular System 333 | 15,192

Target Family

Enzyme 237 | 4,145
Non-IDG 113 | 12,091
Transporter 14 | 473
Kinase 6 | 634

Reactome Pathway

Metabolism of amino acids and ... 370 | 370
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
Sarcosine dehydrogenase, mitochondrial SARDH Tbio Enzyme -1.78290 56.5 35
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.37285 221.6 146
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418