Development Level

Tbio 562 | 11,445
Tdark 76 | 6,588
Tchem 31 | 1,598
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 74 | 979
embryonic lethality prior to o... 24 | 239
embryonic lethality prior to t... 17 | 278
abnormal embryo size 12 | 220
preweaning lethality, incomple... 12 | 499
abnormal behavior 9 | 298
embryonic growth retardation 8 | 106
abnormal bone structure 7 | 187
hypoactivity 6 | 132
prenatal lethality prior to he... 6 | 87
abnormal coat-hair pigmentatio... 5 | 64
cataract 5 | 92
decreased bone mineral density 5 | 126
decreased grip strength 5 | 116
decreased vertical activity 5 | 208
increased mean corpuscular vol... 5 | 92
increased mean platelet volume 5 | 45
abnormal lens morphology 4 | 81
decreased body length 4 | 101
decreased bone mineral content 4 | 151
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased circulating free fat... 4 | 20
increased lean body mass 4 | 172
abnormal retina morphology 3 | 71
decreased caudal vertebrae num... 3 | 53
decreased mean corpuscular hem... 3 | 31
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased fasted circulating g... 3 | 76
increased grip strength 3 | 41
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
male infertility 3 | 123
abnormal behavioral response t... 2 | 66
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal pericardium morpholog... 2 | 26
abnormal snout morphology 2 | 23
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
edema 2 | 59
hyperactivity 2 | 148
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased leukocyte cell numbe... 2 | 47
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
prolonged QT interval 2 | 38
abnormal blood vessel morpholo... 1 | 5
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal esophagus morphology 1 | 5
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal vibrissa morphology 1 | 25
corneal opacity 1 | 32
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased total retina thickne... 1 | 17
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

ovarian cancer 398 | 8,520
Carcinoma 366 | 11,493
osteosarcoma 285 | 7,950
lung cancer 247 | 4,740
medulloblastoma, large-cell 206 | 6,241
psoriasis 195 | 6,694
group 3 medulloblastoma 193 | 4,104
glioblastoma 167 | 5,792
Multiple myeloma 150 | 1,332
atypical teratoid / rhabdoid tumor 132 | 5,112
ependymoma 114 | 4,679
diabetes mellitus 99 | 1,728
oligodendroglioma 99 | 2,850
malignant mesothelioma 97 | 3,232
Breast cancer 95 | 3,578
Waldenstrons macroglobulinemia 91 | 765
intraductal papillary-mucinous neoplasm (IPMN) 87 | 3,291
acute quadriplegic myopathy 86 | 1,158
primitive neuroectodermal tumor 81 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 79 | 2,989
Kidney cancer 75 | 2,613
astrocytic glioma 73 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,955
Cancer 68 | 2,499
adult high grade glioma 68 | 3,801
dermatomyositis 68 | 966
non-small cell lung cancer 63 | 2,890
astrocytoma 61 | 1,146
invasive ductal carcinoma 60 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,962
Pick disease 57 | 1,894
colon cancer 56 | 1,478
lung adenocarcinoma 54 | 2,716
Intellectual disability 49 | 1,016
subependymal giant cell astrocytoma 48 | 2,287
pancreatic cancer 47 | 2,398
acute myeloid leukemia 43 | 783
juvenile dermatomyositis 43 | 1,187
pediatric high grade glioma 42 | 1,064
Astrocytoma, Pilocytic 41 | 3,081
group 4 medulloblastoma 39 | 1,855
breast carcinoma 37 | 1,638
non primary Sjogren syndrome sicca 36 | 891
progressive supranuclear palsy 35 | 676
Autosomal recessive predisposition 32 | 1,442
Rheumatoid arthritis 30 | 1,191
Short stature 30 | 531
tuberculosis 30 | 2,010
Cognitive delay 27 | 608
Global developmental delay 27 | 608
HIV Infections 27 | 102
Mental and motor retardation 27 | 608
Stomach Neoplasms 27 | 300
Diamond-Blackfan anemia 26 | 31
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
hepatocellular carcinoma 26 | 547
Anemia 25 | 365
Fatigue 24 | 182
sonic hedgehog group medulloblastoma 24 | 467
Cardiac Arrhythmia 23 | 103
Cardiac conduction abnormalities 23 | 78
Cleft Palate 23 | 271
Conduction disorder of the heart 23 | 79
EKG abnormalities 23 | 78
Electrocardiogram abnormal 23 | 81
Electrocardiogram change 23 | 78
spina bifida 23 | 1,074
Disease Progression 22 | 136
Optic Atrophy 22 | 242
aldosterone-producing adenoma 22 | 665
Amyotrophic lateral sclerosis 21 | 451
Breast Neoplasms 21 | 445
Intermittent migraine headaches 21 | 68
Migraine Disorders 21 | 76
Uranostaphyloschisis 21 | 167
adrenocortical carcinoma 21 | 1,428
cystic fibrosis 21 | 1,696
Cerebellar Ataxia 20 | 304
Schizophrenia 20 | 1,160
Small head 20 | 374
lung carcinoma 20 | 2,843
pituitary cancer 20 | 1,972
Adenocarcinoma of lung 19 | 142
Disease Models, Animal 19 | 155
Sensorineural Hearing Loss (disorder) 19 | 284
nasopharyngeal carcinoma 19 | 1,058
Gaucher disease type 1 18 | 180
pancreatic carcinoma 18 | 562
tuberculosis and treatment for 6 months 18 | 409
Alzheimer's disease 17 | 658
Myopathy 17 | 185
Polycystic ovary syndrome 17 | 360
medulloblastoma 17 | 720
primary pancreatic ductal adenocarcinoma 17 | 1,109
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275

Tissue

Endocrine System 675 | 18,159
Digestive Tract 673 | 17,369
Blood and immune system 672 | 16,909
Female tissues 671 | 17,400
Male tissues 671 | 17,142
Respiratory system 671 | 16,393
Liver and Pancreas 670 | 16,750
Nervous System 670 | 16,725
Skin and soft tissues 670 | 17,230
Urinary Tract 670 | 16,678
Cardiovascular System 667 | 15,192

Target Family

Non-IDG 456 | 12,091
Enzyme 203 | 4,145
Kinase 15 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
GPCR 1 | 408

Reactome Pathway

Metabolism of RNA 682 | 682
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
NTF2-related export protein 1 NXT1 Tbio Non-IDG -1.49831 29.4 91
Probable tRNA(His) guanylyltransferase THG1L Tbio Enzyme -0.60206 3.69 71
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123