Development Level

Tchem 10 | 1,388
Tbio 3 | 11,651
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal kidney morphology 1 | 65
increased startle reflex 1 | 112
premature death 1 | 5

Disease

Carcinoma 9 | 11,493
lung cancer 9 | 4,740
osteosarcoma 8 | 7,950
psoriasis 8 | 6,694
Cancer 7 | 2,499
Hypertension 7 | 396
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
Kidney disease 6 | 430
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Breast cancer 5 | 3,578
cutaneous lupus erythematosus 5 | 1,057
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
non-small cell lung cancer 5 | 2,890
ovarian cancer 5 | 8,520
ulcerative colitis 5 | 1,819
Anemia 4 | 365
Atherosclerosis 4 | 291
Autosomal recessive predisposition 4 | 1,442
Cerebrovascular disease 4 | 238
Coronary artery disease 4 | 268
Heart disease 4 | 306
Hypertensive disease 4 | 292
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
atypical teratoid / rhabdoid tumor 4 | 5,112
cystic fibrosis 4 | 1,696
glioblastoma 4 | 5,792
malignant mesothelioma 4 | 3,232
Alzheimer's disease 3 | 658
Atopic dermatitis 3 | 952
Diabetic retinopathy 3 | 56
Fibrosis 3 | 44
Hypertrophy, Left Ventricular 3 | 24
Kidney Diseases 3 | 114
Left Ventricular Hypertrophy 3 | 47
Liver Cirrhosis 3 | 181
Lung disease 3 | 142
Multiple myeloma 3 | 1,332
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Small head 3 | 374
Unipolar Depression 3 | 250
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 807
primary pancreatic ductal adenocarcinoma 3 | 1,109
subependymal giant cell astrocytoma 3 | 2,287
urothelial carcinoma 3 | 318
Adenoma 2 | 167
Angioedema 2 | 38
Asthma 2 | 385
Bipolar Disorder 2 | 666
Cardiomegaly 2 | 116
Depressive disorder 2 | 409
Diabetes Mellitus, Experimental 2 | 108
Diabetic Nephropathies 2 | 37
Diabetic Nephropathy 2 | 34
Duchenne muscular dystrophy 2 | 601
Endomyocardial Fibrosis 2 | 13
Essential Hypertension 2 | 94
Focal glomerulosclerosis 2 | 37
Heart failure 2 | 162
Hyperaldosteronism 2 | 35
Hyperglycemia 2 | 137
Hypokalemia 2 | 52
Hypotension 2 | 82
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Mental Depression 2 | 333
Myocardial Infarction 2 | 151
Nephrosis 2 | 21
Potter's facies 2 | 10
Prostatic Neoplasms 2 | 495
Proteinuria 2 | 144
Pulmonary Fibrosis 2 | 106
Renal Insufficiency 2 | 90
Renal dysplasia 2 | 28
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Rheumatoid arthritis 2 | 1,191
Skin cancer 2 | 469
Ureteral obstruction 2 | 33
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 4,104
mucosa-associated lymphoid tissue lymphoma 2 | 484
nephrosclerosis 2 | 333
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192
Skin and soft tissues 14 | 17,230

Target Family

Enzyme 13 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Metabolism of Angiotensinogen ... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81719 655.7 311
Angiotensinogen AGT Tbio Non-IDG -3.24591 1711.3 695
Neprilysin MME Tclin Enzyme -3.64168 4375.8 1505
Renin REN Tclin Enzyme -4.53626 33160.7 508
Chymase CMA1 Tchem Enzyme -3.03589 1121.1 278
Cathepsin G CTSG Tchem Enzyme -2.93874 834.3 272
Renin receptor ATP6AP2 Tbio Non-IDG -2.32908 192.9 236
Aminopeptidase N ANPEP Tchem Enzyme -3.28127 1843.4 1222
Mast cell carboxypeptidase A CPA3 Tchem Enzyme -1.72972 50.2 151
Carboxypeptidase B CPB1 Tchem Enzyme -2.97696 883.0 228