Development Level

Tchem 11 | 1,890
Tclin 3 | 602
Tbio 2 | 10,625

IMPC Term

abnormal kidney morphology 1 | 30
premature death 1 | 5
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26

Disease

Hypertension 8 | 287
lung adenocarcinoma 8 | 2,713
lung cancer 8 | 4,466
osteosarcoma 8 | 7,933
psoriasis 8 | 6,685
Kidney disease 7 | 396
diabetes mellitus 7 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
invasive ductal carcinoma 7 | 2,950
lung carcinoma 7 | 2,844
Cancer 6 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
Anemia 5 | 252
Atherosclerosis 5 | 275
Breast cancer 5 | 3,094
Cerebrovascular disease 5 | 231
Coronary artery disease 5 | 240
Heart disease 5 | 279
Hypertensive disease 5 | 193
cutaneous lupus erythematosus 5 | 1,056
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
medulloblastoma, large-cell 5 | 6,234
non-small cell lung cancer 5 | 2,798
ovarian cancer 5 | 8,484
ulcerative colitis 5 | 2,087
Alzheimer's disease 4 | 644
Kidney Diseases 4 | 86
Left Ventricular Hypertrophy 4 | 24
Lung disease 4 | 132
Obesity 4 | 616
cystic fibrosis 4 | 1,665
malignant mesothelioma 4 | 3,162
Albuminuria 3 | 20
Allanson Pantzar McLeod syndrome 3 | 4
Angioedema 3 | 36
Asthma 3 | 349
Atopic dermatitis 3 | 944
Carcinoma 3 | 2,147
Diabetes Mellitus, Experimental 3 | 106
Diabetic Nephropathy 3 | 37
Diabetic Retinopathy 3 | 53
Fibrosis 3 | 40
Heart failure 3 | 80
Hyperaldosteronism 3 | 27
Hyperglycemia 3 | 120
Hypokalemia 3 | 40
Hypotension 3 | 53
IGA Glomerulonephritis 3 | 454
Metabolic syndrome X 3 | 155
Multiple myeloma 3 | 1,327
Myocardial Infarction 3 | 126
Neurodegenerative disease 3 | 383
Oligohydramnios 3 | 18
Prostatic Neoplasms 3 | 471
Renal Insufficiency 3 | 10
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
atypical teratoid / rhabdoid tumor 3 | 4,369
breast carcinoma 3 | 1,614
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 832
glioblastoma 3 | 5,572
primary pancreatic ductal adenocarcinoma 3 | 1,271
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,557
urothelial carcinoma 3 | 318
Adenoma 2 | 165
Allergic hypersensitivity disease 2 | 123
Aortic aneurysm 2 | 34
Cardiomegaly 2 | 66
Cardiovascular Diseases 2 | 50
Chronic heart failure 2 | 46
Congestive heart failure 2 | 30
Conn's syndrome 2 | 22
Connective tissue disease 2 | 59
Duchenne muscular dystrophy 2 | 602
Essential Hypertension 2 | 82
Hypertensive disorder 2 | 58
Lipid metabolism disorder 2 | 102
Liver Cirrhosis 2 | 101
Liver Cirrhosis, Experimental 2 | 108
Liver carcinoma 2 | 217
Neuropathy 2 | 210
Polycystic kidney disease 2 | 54
Proteinuria 2 | 63
Pulmonary hypertension 2 | 52
Severe acute respiratory syndrome 2 | 26
Vasculitis 2 | 64
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
colon cancer 2 | 1,475
esophageal adenocarcinoma 2 | 737
facioscapulohumeral dystrophy 2 | 286
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329
pancreatic cancer 2 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pre-eclampsia 2 | 67
sarcoidosis 2 | 358

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Enzyme 14 | 4,146
Non-IDG 2 | 11,971

Reactome Pathway

Metabolism of Angiotensinogen ... 16 | 16
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81004 644.6 267
Angiotensinogen AGT Tchem Non-IDG -3.23051 1673.4 609
Aminopeptidase N ANPEP Tchem Enzyme -3.24618 1759.9 972
Angiotensin-converting enzyme 2 ACE2 Tchem Enzyme -2.95438 1065.5 610
Carboxypeptidase B CPB1 Tchem Enzyme -2.95271 854.2 199
Mast cell carboxypeptidase A CPA3 Tchem Enzyme -1.70562 49.0 134
Renin receptor ATP6AP2 Tbio Non-IDG -2.26367 175.3 213
Angiotensin-converting enzyme ACE Tclin Enzyme -4.50155 29360.4 544
Neprilysin MME Tclin Enzyme -3.60000 4179.2 1274
Cathepsin G CTSG Tchem Enzyme -2.92068 822.6 240