Development Level

Tbio 1,398 | 11,445
Tchem 390 | 1,598
Tclin 158 | 613
Tdark 135 | 6,588

Collection

Kinase: IDG Consortium (Target... 13 | 125
Ion Channel: IDG Consortium (T... 6 | 99
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 146 | 979
preweaning lethality, incomple... 62 | 499
embryonic lethality prior to o... 42 | 239
embryonic lethality prior to t... 41 | 278
abnormal behavior 38 | 298
abnormal embryo size 35 | 220
decreased total body fat amoun... 31 | 207
decreased vertical activity 27 | 208
enlarged heart 27 | 210
abnormal heart morphology 25 | 162
increased lean body mass 24 | 172
cataract 22 | 92
abnormal bone structure 21 | 187
decreased body weight 21 | 161
increased startle reflex 21 | 112
abnormal lens morphology 19 | 81
embryonic growth retardation 19 | 106
decreased bone mineral density 18 | 126
decreased circulating glucose ... 18 | 126
hypoactivity 18 | 132
increased bone mineral content 18 | 108
decreased bone mineral content 17 | 151
hyperactivity 17 | 148
male infertility 15 | 123
decreased body length 14 | 101
decreased circulating choleste... 14 | 93
decreased mean corpuscular vol... 14 | 79
increased bone mineral density 14 | 72
increased heart weight 14 | 62
increased total body fat amoun... 14 | 134
abnormal retina morphology 13 | 71
abnormal seminal vesicle morph... 13 | 114
increased mean corpuscular hem... 13 | 96
increased circulating alkaline... 12 | 122
increased or absent threshold ... 12 | 101
decreased circulating HDL chol... 11 | 68
decreased circulating alkaline... 11 | 46
decreased circulating serum al... 11 | 82
decreased circulating triglyce... 11 | 79
decreased fasted circulating g... 11 | 65
decreased leukocyte cell numbe... 11 | 73
decreased prepulse inhibition 11 | 82
impaired glucose tolerance 11 | 75
increased mean corpuscular vol... 11 | 92
abnormal neural tube closure 10 | 46
abnormal sleep behavior 10 | 70
decreased erythrocyte cell num... 10 | 62
decreased grip strength 10 | 116
decreased lymphocyte cell numb... 10 | 83
increased circulating sodium l... 10 | 71
small superior vagus ganglion 10 | 74
decreased lean body mass 9 | 135
hydrometra 9 | 53
increased circulating choleste... 9 | 66
increased fasted circulating g... 9 | 76
increased monocyte cell number 9 | 63
short tibia 9 | 97
abnormal kidney morphology 8 | 65
abnormal testis morphology 8 | 43
decreased circulating alanine ... 8 | 47
improved glucose tolerance 8 | 79
increased blood urea nitrogen ... 8 | 48
increased circulating HDL chol... 8 | 80
pallor 8 | 34
prenatal lethality prior to he... 8 | 87
small testis 8 | 58
thrombocytopenia 8 | 56
abnormal craniofacial morpholo... 7 | 33
abnormal epididymis morphology 7 | 42
abnormal eye morphology 7 | 68
abnormal gait 7 | 69
decreased circulating total pr... 7 | 49
decreased hemoglobin content 7 | 68
decreased neutrophil cell numb... 7 | 42
increased mean platelet volume 7 | 45
microphthalmia 7 | 26
persistence of hyaloid vascula... 7 | 33
thin ventricular wall 7 | 24
abnormal coat appearance 6 | 31
abnormal retinal vasculature m... 6 | 27
abnormal skin morphology 6 | 50
abnormal spleen morphology 6 | 55
abnormal vocalization 6 | 21
anophthalmia 6 | 33
decreased caudal vertebrae num... 6 | 53
decreased circulating calcium ... 6 | 36
decreased circulating chloride... 6 | 30
decreased circulating creatini... 6 | 39
decreased circulating iron lev... 6 | 32
decreased circulating phosphat... 6 | 27
decreased startle reflex 6 | 75
edema 6 | 59
enlarged lymph nodes 6 | 37
increased circulating bilirubi... 6 | 16
increased circulating phosphat... 6 | 26
small kidney 6 | 16
abnormal placenta size 5 | 20
decreased circulating LDL chol... 5 | 38
decreased circulating aspartat... 5 | 34
pale yolk sac 5 | 25

Disease

Carcinoma 1,238 | 11,493
ovarian cancer 1,079 | 8,520
osteosarcoma 894 | 7,950
psoriasis 856 | 6,694
medulloblastoma, large-cell 714 | 6,241
glioblastoma 642 | 5,792
lung cancer 642 | 4,740
atypical teratoid / rhabdoid tumor 543 | 5,112
ependymoma 492 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 487 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 450 | 1,962
group 3 medulloblastoma 437 | 4,104
Autosomal recessive predisposition 414 | 1,442
malignant mesothelioma 414 | 3,232
adult high grade glioma 399 | 3,801
Breast cancer 397 | 3,578
invasive ductal carcinoma 391 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 390 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 378 | 2,989
non-small cell lung cancer 359 | 2,890
lung carcinoma 342 | 2,843
Cancer 339 | 2,499
lung adenocarcinoma 330 | 2,716
Astrocytoma, Pilocytic 324 | 3,081
oligodendroglioma 320 | 2,850
pancreatic cancer 310 | 2,398
primitive neuroectodermal tumor 309 | 3,035
astrocytic glioma 303 | 2,597
interstitial cystitis 287 | 2,312
subependymal giant cell astrocytoma 272 | 2,287
diabetes mellitus 269 | 1,728
tuberculosis 267 | 2,010
Multiple myeloma 266 | 1,332
ductal carcinoma in situ 256 | 1,745
ulcerative colitis 256 | 1,819
Pick disease 239 | 1,894
pituitary cancer 235 | 1,972
Epilepsy 225 | 792
Kidney cancer 221 | 2,613
cystic fibrosis 217 | 1,696
adrenocortical carcinoma 207 | 1,428
colon cancer 207 | 1,478
Intellectual disability 206 | 1,016
Schizophrenia 202 | 1,160
group 4 medulloblastoma 201 | 1,855
Seizures 192 | 596
breast carcinoma 192 | 1,638
Muscle hypotonia 186 | 571
Cognitive delay 185 | 608
Global developmental delay 185 | 608
Mental and motor retardation 185 | 608
Obesity 177 | 678
Liver Cirrhosis, Experimental 169 | 769
astrocytoma 169 | 1,146
Dull intelligence 164 | 645
Low intelligence 164 | 645
Mental Retardation 164 | 645
Mental deficiency 164 | 645
Poor school performance 164 | 645
active Crohn's disease 155 | 922
acute quadriplegic myopathy 155 | 1,158
Waldenstrons macroglobulinemia 147 | 765
active ulcerative colitis 137 | 764
Rheumatoid arthritis 136 | 1,191
Failure to gain weight 133 | 365
Pediatric failure to thrive 133 | 365
primary pancreatic ductal adenocarcinoma 131 | 1,109
cutaneous lupus erythematosus 127 | 1,057
Bipolar Disorder 125 | 666
Atopic dermatitis 123 | 952
dermatomyositis 123 | 966
non primary Sjogren syndrome sicca 119 | 891
pediatric high grade glioma 119 | 1,064
juvenile dermatomyositis 117 | 1,187
aldosterone-producing adenoma 114 | 665
Prostatic Neoplasms 113 | 495
gastric carcinoma 109 | 807
nasopharyngeal carcinoma 108 | 1,058
Cerebellar Ataxia 106 | 304
esophageal adenocarcinoma 106 | 737
Hepatomegaly 103 | 285
Short stature 103 | 531
spina bifida 101 | 1,074
acute myeloid leukemia 97 | 783
Anemia 95 | 365
Hypertension 91 | 396
Depressive disorder 89 | 409
Hypoglycemia 88 | 152
medulloblastoma 88 | 720
primary Sjogren syndrome 88 | 735
nephrosclerosis 87 | 333
fibroadenoma 86 | 559
Nystagmus 84 | 317
Alzheimer's disease 83 | 658
Breast Neoplasms 83 | 445
Mammary Neoplasms 82 | 425
Melanoma 80 | 711
Osteoporosis 79 | 363
Duchenne muscular dystrophy 78 | 601
Infantile onset 77 | 238

Tissue

Endocrine System 2,034 | 18,159
Digestive Tract 2,031 | 17,369
Female tissues 2,020 | 17,400
Skin and soft tissues 2,010 | 17,230
Liver and Pancreas 2,004 | 16,750
Urinary Tract 1,999 | 16,678
Male tissues 1,991 | 17,142
Blood and immune system 1,983 | 16,909
Nervous System 1,966 | 16,725
Respiratory system 1,937 | 16,393
Cardiovascular System 1,846 | 15,192

Target Family

Enzyme 1,296 | 4,145
Non-IDG 499 | 12,091
Kinase 132 | 634
Transporter 86 | 473
Transcription Factor 25 | 1,400
Ion Channel 16 | 344
Nuclear Receptor 12 | 48
Epigenetic 8 | 242
GPCR 6 | 408
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism 2,081 | 2,081
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinoic acid receptor responder protein 3 RARRES3 Tbio Non-IDG -1.84020 71.0 164
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
HRAS-like suppressor 2 HRASLS2 Tbio Non-IDG -0.19299 1.65 72
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Mediator of RNA polymerase II transcription subunit 29 MED29 Tbio Enzyme -1.76053 56.0 45
Uridine-cytidine kinase-like 1 UCKL1 Tdark Kinase -0.15970 2.21 110