Development Level

Tbio 1,323 | 10,625
Tchem 489 | 1,890
Tclin 161 | 602
Tdark 159 | 7,003

Collection

Eligible Kinase Proteins 22 | 134
Eligible Ion Channel Proteins 7 | 117

IMPC Term

preweaning lethality, complete... 98 | 633
abnormal behavior 32 | 226
embryonic lethality prior to o... 32 | 148
embryonic lethality prior to t... 31 | 187
preweaning lethality, incomple... 31 | 260
decreased total body fat amoun... 26 | 186
decreased body weight 24 | 174
abnormal embryo size 22 | 112
abnormal retina morphology 20 | 100
decreased lean body mass 19 | 195
decreased bone mineral content 17 | 157
decreased circulating glucose ... 17 | 121
hypoactivity 17 | 89
abnormal bone structure 16 | 131
abnormal lens morphology 16 | 73
increased circulating alkaline... 15 | 119
decreased circulating HDL chol... 14 | 77
decreased circulating triglyce... 13 | 83
decreased grip strength 13 | 123
increased lean body mass 13 | 107
decreased body length 12 | 108
decreased bone mineral density 12 | 126
decreased circulating choleste... 12 | 85
decreased circulating serum al... 12 | 79
enlarged heart 12 | 111
hyperactivity 12 | 108
increased or absent threshold ... 12 | 128
abnormal retinal pigmentation 11 | 61
decreased circulating alkaline... 11 | 41
increased bone mineral content 11 | 92
increased mean corpuscular hem... 11 | 93
abnormal bone mineralization 10 | 55
increased circulating sodium l... 10 | 71
increased fasted circulating g... 10 | 68
increased mean corpuscular vol... 10 | 91
abnormal neural tube closure 9 | 37
abnormal sleep behavior 9 | 63
decreased circulating insulin ... 9 | 75
increased body weight 9 | 42
increased circulating choleste... 9 | 53
increased exploration in new e... 9 | 56
increased grip strength 9 | 83
increased heart weight 9 | 37
decreased circulating alanine ... 8 | 53
decreased mean corpuscular vol... 8 | 50
prenatal lethality prior to he... 8 | 64
thrombocytopenia 8 | 46
abnormal coat appearance 7 | 25
decreased caudal vertebrae num... 7 | 49
decreased circulating calcium ... 7 | 33
decreased circulating creatini... 7 | 31
decreased eosinophil cell numb... 7 | 41
decreased fasted circulating g... 7 | 49
decreased leukocyte cell numbe... 7 | 54
embryonic growth retardation 7 | 28
impaired glucose tolerance 7 | 52
increased bone mineral density 7 | 52
increased total body fat amoun... 7 | 57
male infertility 7 | 62
abnormal epididymis morphology 6 | 31
abnormal heart morphology 6 | 51
abnormal seminal vesicle morph... 6 | 47
abnormal testis morphology 6 | 30
cardiovascular system phenotyp... 6 | 35
decreased NK T cell number 6 | 28
decreased mean platelet volume 6 | 12
decreased prepulse inhibition 6 | 52
decreased startle reflex 6 | 48
enlarged lymph nodes 6 | 27
improved glucose tolerance 6 | 56
increased blood urea nitrogen ... 6 | 44
increased circulating HDL chol... 6 | 63
increased circulating bilirubi... 6 | 16
increased circulating potassiu... 6 | 31
short tibia 6 | 82
small kidney 6 | 10
small testis 6 | 37
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
abnormal spleen morphology 5 | 36
abnormal vocalization 5 | 21
decreased Ly6C low monocyte nu... 5 | 23
decreased circulating chloride... 5 | 32
decreased circulating glycerol... 5 | 19
decreased circulating total pr... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased hemoglobin content 5 | 53
decreased lumbar vertebrae num... 5 | 62
decreased neutrophil cell numb... 5 | 37
decreased threshold for audito... 5 | 32
enlarged epididymis 5 | 27
enlarged spleen 5 | 26
increased circulating phosphat... 5 | 24
increased startle reflex 5 | 38
microphthalmia 5 | 15
small adrenal glands 5 | 15
abnormal coat/hair pigmentatio... 4 | 54
decreased circulating LDL chol... 4 | 37
increased circulating calcium ... 4 | 32
increased erythrocyte cell num... 4 | 26

Disease

ovarian cancer 1,102 | 8,484
osteosarcoma 905 | 7,933
psoriasis 887 | 6,685
medulloblastoma, large-cell 724 | 6,234
lung cancer 655 | 4,466
glioblastoma 635 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 510 | 3,289
atypical teratoid / rhabdoid tumor 470 | 4,369
malignant mesothelioma 430 | 3,162
pancreatic ductal adenocarcinoma liver metastasis 427 | 1,795
intraductal papillary-mucinous adenoma (IPMA) 411 | 2,956
invasive ductal carcinoma 402 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 399 | 2,988
non-small cell lung cancer 365 | 2,798
Breast cancer 362 | 3,094
lung carcinoma 362 | 2,844
lung adenocarcinoma 352 | 2,713
Cancer 328 | 2,346
pilocytic astrocytoma 328 | 3,086
oligodendroglioma 326 | 2,849
pancreatic cancer 325 | 2,300
ulcerative colitis 322 | 2,087
primitive neuroectodermal tumor 308 | 3,031
interstitial cystitis 301 | 2,299
pediatric high grade glioma 297 | 2,712
subependymal giant cell astrocytoma 282 | 2,287
Multiple myeloma 280 | 1,327
ependymoma 278 | 2,514
diabetes mellitus 273 | 1,663
ductal carcinoma in situ 265 | 1,745
astrocytic glioma 263 | 2,241
pituitary cancer 245 | 1,972
group 3 medulloblastoma 239 | 2,254
Pick disease 238 | 1,893
adult high grade glioma 227 | 2,148
astrocytoma 222 | 1,493
adrenocortical carcinoma 220 | 1,427
colon cancer 220 | 1,475
group 4 medulloblastoma 220 | 1,875
cystic fibrosis 214 | 1,665
tuberculosis 214 | 1,557
breast carcinoma 201 | 1,614
Obesity 176 | 616
medulloblastoma 175 | 1,524
active Crohn's disease 169 | 918
posterior fossa group A ependymoma 168 | 1,511
acute quadriplegic myopathy 167 | 1,157
primary pancreatic ductal adenocarcinoma 167 | 1,271
sonic hedgehog group medulloblastoma 160 | 1,482
Carcinoma 156 | 2,147
Waldenstrons macroglobulinemia 153 | 765
posterior fossa group B ependymoma 146 | 1,530
Rheumatoid Arthritis 138 | 1,160
cutaneous lupus erythematosus 130 | 1,056
atypical teratoid/rhabdoid tumor 129 | 1,095
Atopic dermatitis 128 | 944
dermatomyositis 128 | 933
gastric carcinoma 121 | 832
juvenile dermatomyositis 121 | 1,189
non primary Sjogren syndrome sicca 117 | 840
esophageal adenocarcinoma 113 | 737
Prostatic Neoplasms 111 | 471
nasopharyngeal carcinoma 110 | 1,056
aldosterone-producing adenoma 107 | 664
spina bifida 103 | 1,064
acute myeloid leukemia 100 | 780
Alzheimer's disease 93 | 644
primary Sjogren syndrome 90 | 789
fibroadenoma 89 | 557
nephrosclerosis 89 | 329
Atherosclerosis 86 | 275
Down syndrome 86 | 548
Duchenne muscular dystrophy 84 | 602
Intellectual disability 80 | 573
Mammary Neoplasms 80 | 410
active ulcerative colitis 80 | 477
Endometriosis 78 | 535
mucosa-associated lymphoid tissue lymphoma 76 | 480
pancreatic carcinoma 76 | 567
tuberculosis and treatment for 6 months 73 | 686
Liver carcinoma 72 | 217
progressive supranuclear palsy 70 | 674
Kidney disease 69 | 396
Metabolic syndrome X 69 | 155
Neurodegenerative disease 69 | 383
Peripheral Neuropathy 68 | 303
Schizophrenia 68 | 501
Coronary artery disease 67 | 240
Polycystic Ovary Syndrome 67 | 332
IGA Glomerulonephritis 66 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 65 | 499
Hypertension 62 | 287
Diabetes mellitus type 2 60 | 69
Leigh disease 60 | 81
Stomach Neoplasms 60 | 282
Epilepsy 58 | 346
Liver disease 58 | 219
chronic rhinosinusitis 58 | 512
hepatocellular carcinoma 58 | 532
hereditary spastic paraplegia 58 | 313

Tissue

Digestive Tract 2,118 | 18,473
Liver and Pancreas 2,116 | 18,136
Nervous System 2,115 | 18,561
Urinary Tract 2,114 | 18,444
Female tissues 2,112 | 18,647
Endocrine System 2,110 | 18,512
Blood and immune system 2,105 | 17,995
Cardiovascular System 2,095 | 17,958
Skin and soft tissues 2,094 | 18,115
Male tissues 2,093 | 17,969
Respiratory system 2,068 | 17,484

Target Family

Enzyme 1,317 | 4,146
Non-IDG 521 | 11,971
Kinase 127 | 634
Transporter 97 | 473
Transcription Factor 29 | 1,400
Ion Channel 16 | 341
Nuclear Receptor 10 | 48
Epigenetic 8 | 242
GPCR 6 | 406
TF/Epigenetic 1 | 38

Reactome Pathway

Metabolism 2,132 | 2,132
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106