Development Level

Tbio 503 | 11,651
Tdark 57 | 6,593
Tchem 37 | 1,388
Tclin 11 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 71 | 979
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 20 | 278
abnormal embryo size 18 | 220
embryonic lethality prior to o... 17 | 239
abnormal behavior 14 | 298
decreased total body fat amoun... 13 | 207
decreased circulating choleste... 12 | 93
decreased vertical activity 11 | 208
decreased body weight 9 | 161
enlarged heart 9 | 210
hyperactivity 9 | 148
decreased bone mineral content 8 | 151
decreased circulating HDL chol... 8 | 68
decreased circulating LDL chol... 8 | 38
embryonic growth retardation 8 | 106
increased lean body mass 8 | 172
increased mean corpuscular vol... 8 | 92
abnormal heart morphology 7 | 162
decreased circulating alanine ... 7 | 47
decreased mean corpuscular hem... 7 | 50
increased circulating alkaline... 7 | 122
abnormal bone structure 6 | 187
abnormal lens morphology 6 | 81
abnormal seminal vesicle morph... 6 | 114
cataract 6 | 92
decreased caudal vertebrae num... 6 | 53
decreased circulating serum al... 6 | 82
decreased circulating triglyce... 6 | 79
decreased leukocyte cell numbe... 6 | 73
hydrometra 6 | 53
increased fasted circulating g... 6 | 76
increased hematocrit 6 | 46
increased or absent threshold ... 6 | 101
prenatal lethality prior to he... 6 | 87
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
cardiovascular system phenotyp... 5 | 36
decreased circulating insulin ... 5 | 76
decreased fasted circulating g... 5 | 65
decreased grip strength 5 | 116
enlarged lymph nodes 5 | 37
enlarged spleen 5 | 41
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
increased mean corpuscular hem... 5 | 96
increased startle reflex 5 | 112
abnormal kidney morphology 4 | 65
abnormal spleen morphology 4 | 55
decreased bone mineral density 4 | 126
decreased circulating aspartat... 4 | 34
decreased circulating free fat... 4 | 31
decreased circulating glucose ... 4 | 126
decreased hemoglobin content 4 | 68
decreased mean corpuscular vol... 4 | 79
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased grip strength 4 | 41
increased heart weight 4 | 62
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo turning 3 | 31
abnormal pericardium morpholog... 3 | 26
abnormal testis morphology 3 | 43
decreased blood urea nitrogen ... 3 | 51
decreased circulating amylase ... 3 | 28
decreased circulating total pr... 3 | 49
decreased hematocrit 3 | 46
decreased lactate dehydrogenas... 3 | 16
decreased lean body mass 3 | 135
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular hem... 3 | 36
increased mean platelet volume 3 | 45
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytopenia 3 | 56
thrombocytosis 3 | 27
abnormal eye morphology 2 | 68
abnormal liver morphology 2 | 17
decreased circulating potassiu... 2 | 20
decreased heart rate variabili... 2 | 13
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26

Disease

Carcinoma 394 | 11,493
ovarian cancer 385 | 8,520
osteosarcoma 324 | 7,950
medulloblastoma, large-cell 243 | 6,241
glioblastoma 229 | 5,792
psoriasis 229 | 6,694
atypical teratoid / rhabdoid tumor 205 | 5,112
ependymoma 172 | 4,679
lung cancer 172 | 4,740
adult high grade glioma 143 | 3,801
Breast cancer 133 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 125 | 3,291
malignant mesothelioma 125 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,955
Kidney cancer 117 | 2,613
group 3 medulloblastoma 117 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 117 | 2,989
invasive ductal carcinoma 114 | 2,951
Astrocytoma, Pilocytic 108 | 3,081
non-small cell lung cancer 103 | 2,890
lung carcinoma 97 | 2,843
oligodendroglioma 97 | 2,850
astrocytic glioma 93 | 2,597
primitive neuroectodermal tumor 93 | 3,035
Pick disease 92 | 1,894
lung adenocarcinoma 92 | 2,716
subependymal giant cell astrocytoma 89 | 2,287
pancreatic cancer 87 | 2,398
Multiple myeloma 83 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 83 | 1,962
group 4 medulloblastoma 79 | 1,855
Cancer 77 | 2,499
diabetes mellitus 76 | 1,728
tuberculosis 73 | 2,010
Autosomal recessive predisposition 70 | 1,442
interstitial cystitis 70 | 2,312
acute quadriplegic myopathy 69 | 1,158
breast carcinoma 62 | 1,638
ductal carcinoma in situ 61 | 1,745
astrocytoma 57 | 1,146
dermatomyositis 57 | 966
pituitary cancer 56 | 1,972
juvenile dermatomyositis 54 | 1,187
spina bifida 54 | 1,074
Schizophrenia 49 | 1,160
adrenocortical carcinoma 49 | 1,428
primary pancreatic ductal adenocarcinoma 49 | 1,109
Intellectual disability 48 | 1,016
Rheumatoid arthritis 47 | 1,191
cystic fibrosis 47 | 1,696
Epilepsy 46 | 792
colon cancer 43 | 1,478
ulcerative colitis 43 | 1,819
Waldenstrons macroglobulinemia 41 | 765
pediatric high grade glioma 40 | 1,064
Neurodegenerative disease 39 | 414
Alzheimer's disease 36 | 658
Cognitive delay 36 | 608
Global developmental delay 36 | 608
Mental and motor retardation 36 | 608
cutaneous lupus erythematosus 35 | 1,057
non primary Sjogren syndrome sicca 35 | 891
Atopic dermatitis 33 | 952
Dull intelligence 33 | 645
Low intelligence 33 | 645
Mental Retardation 33 | 645
Mental deficiency 33 | 645
Poor school performance 33 | 645
Seizures 33 | 596
Bipolar Disorder 31 | 666
acute myeloid leukemia 31 | 783
gastric carcinoma 30 | 807
hereditary spastic paraplegia 30 | 318
esophageal adenocarcinoma 29 | 737
Liver Cirrhosis, Experimental 28 | 769
progressive supranuclear palsy 28 | 676
Muscle hypotonia 27 | 571
active Crohn's disease 27 | 922
aldosterone-producing adenoma 27 | 665
primary Sjogren syndrome 27 | 735
Liver cancer 26 | 604
Down syndrome 24 | 499
Small head 24 | 374
hepatocellular carcinoma 24 | 547
Neuropathy 23 | 261
Parkinson's disease 23 | 392
pancreatic carcinoma 23 | 562
Amyotrophic lateral sclerosis 22 | 451
sonic hedgehog group medulloblastoma 22 | 467
Duchenne muscular dystrophy 21 | 601
Melanoma 21 | 711
medulloblastoma 21 | 720
tuberculosis and treatment for 6 months 21 | 409
Depressive disorder 20 | 409
Endometriosis 20 | 540
Gaucher disease type 1 20 | 180
Short stature 20 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
mucosa-associated lymphoid tissue lymphoma 20 | 484
nasopharyngeal carcinoma 20 | 1,058

Tissue

Endocrine System 603 | 18,159
Female tissues 599 | 17,400
Skin and soft tissues 599 | 17,230
Digestive Tract 597 | 17,369
Urinary Tract 595 | 16,678
Male tissues 593 | 17,142
Blood and immune system 591 | 16,909
Liver and Pancreas 591 | 16,750
Nervous System 589 | 16,725
Respiratory system 588 | 16,393
Cardiovascular System 579 | 15,192

Target Family

Non-IDG 478 | 12,091
Enzyme 102 | 4,145
Kinase 15 | 634
GPCR 6 | 408
Transporter 3 | 473
Ion Channel 2 | 344
Transcription Factor 2 | 1,400

Reactome Pathway

Membrane Trafficking 608 | 608
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Alkaline phosphatase, placental type ALPP Tbio Enzyme -2.71952 511.2 929
ADP-ribosylation factor GTPase-activating protein 2 ARFGAP2 Tbio Enzyme -0.97596 10.1 144
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Coatomer subunit beta COPB1 Tbio Non-IDG -1.94049 82.6 148