Development Level

Tbio 472 | 10,625
Tdark 65 | 7,003
Tchem 60 | 1,890
Tclin 11 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 47 | 633
embryonic lethality prior to t... 17 | 187
decreased total body fat amoun... 14 | 186
abnormal behavior 12 | 226
embryonic lethality prior to o... 12 | 148
increased or absent threshold ... 12 | 128
decreased circulating choleste... 11 | 85
decreased lean body mass 11 | 195
preweaning lethality, incomple... 11 | 260
abnormal embryo size 9 | 112
decreased body weight 9 | 174
decreased circulating HDL chol... 9 | 77
decreased circulating LDL chol... 9 | 37
decreased grip strength 9 | 123
increased circulating alkaline... 9 | 119
increased mean corpuscular vol... 9 | 91
abnormal lens morphology 8 | 73
decreased bone mineral content 8 | 157
decreased circulating alanine ... 8 | 53
decreased circulating triglyce... 8 | 83
increased hematocrit 8 | 36
abnormal bone structure 7 | 131
increased bone mineral content 7 | 92
increased mean corpuscular hem... 7 | 93
abnormal sleep behavior 6 | 63
decreased body length 6 | 108
decreased bone mineral density 6 | 126
decreased circulating serum al... 6 | 79
enlarged heart 6 | 111
hyperactivity 6 | 108
increased lean body mass 6 | 107
cardiovascular system phenotyp... 5 | 35
decreased caudal vertebrae num... 5 | 49
decreased circulating free fat... 5 | 39
decreased circulating glucose ... 5 | 121
decreased circulating insulin ... 5 | 75
decreased fasted circulating g... 5 | 49
decreased leukocyte cell numbe... 5 | 54
decreased mean corpuscular hem... 5 | 34
decreased mean corpuscular vol... 5 | 50
decreased startle reflex 5 | 48
increased fasted circulating g... 5 | 68
increased grip strength 5 | 83
decreased hematocrit 4 | 25
decreased hemoglobin content 4 | 53
decreased rib number 4 | 59
enlarged lymph nodes 4 | 27
enlarged spleen 4 | 26
hydrometra 4 | 13
hypoactivity 4 | 89
impaired glucose tolerance 4 | 52
increased body weight 4 | 42
increased circulating HDL chol... 4 | 63
increased erythrocyte cell num... 4 | 26
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular hem... 4 | 25
increased sacral vertebrae num... 4 | 62
prenatal lethality prior to he... 4 | 64
abnormal behavioral response t... 3 | 52
abnormal coat/hair pigmentatio... 3 | 54
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal kidney morphology 3 | 30
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal retina morphology 3 | 100
abnormal testis morphology 3 | 30
decreased CD8-positive, alpha-... 3 | 26
decreased T cell number 3 | 31
decreased circulating aspartat... 3 | 27
decreased circulating total pr... 3 | 41
decreased gamma-delta T cell n... 3 | 18
decreased heart rate variabili... 3 | 11
decreased lactate dehydrogenas... 3 | 14
decreased lumbar vertebrae num... 3 | 62
decreased total retina thickne... 3 | 20
decreased vertical activity 3 | 22
hydrops fetalis 3 | 22
increased bone mineral density 3 | 52
increased circulating LDL chol... 3 | 15
increased circulating choleste... 3 | 53
increased circulating potassiu... 3 | 31
increased circulating sodium l... 3 | 71
increased startle reflex 3 | 38
limb grasping 3 | 35
short tibia 3 | 82
thrombocytopenia 3 | 46
thrombocytosis 3 | 23
abnormal body wall morphology 2 | 7
abnormal retinal inner nuclear... 2 | 5
abnormal spleen morphology 2 | 36
decreased circulating potassiu... 2 | 17
decreased effector memory CD8-... 2 | 24
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 43
increased heart weight 2 | 37
increased prepulse inhibition 2 | 21
increased total body fat amoun... 2 | 57
small testis 2 | 37

Disease

ovarian cancer 377 | 8,484
osteosarcoma 322 | 7,933
medulloblastoma, large-cell 243 | 6,234
psoriasis 230 | 6,685
glioblastoma 222 | 5,572
atypical teratoid / rhabdoid tumor 188 | 4,369
lung cancer 164 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 125 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,956
malignant mesothelioma 120 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 117 | 2,988
Breast cancer 115 | 3,094
invasive ductal carcinoma 114 | 2,950
pilocytic astrocytoma 112 | 3,086
pediatric high grade glioma 108 | 2,712
ependymoma 104 | 2,514
Carcinoma 103 | 2,147
non-small cell lung cancer 99 | 2,798
oligodendroglioma 97 | 2,849
lung carcinoma 96 | 2,844
primitive neuroectodermal tumor 94 | 3,031
Pick disease 92 | 1,893
lung adenocarcinoma 90 | 2,713
subependymal giant cell astrocytoma 88 | 2,287
pancreatic cancer 83 | 2,300
Multiple myeloma 82 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 82 | 1,795
astrocytoma 79 | 1,493
group 4 medulloblastoma 76 | 1,875
adult high grade glioma 75 | 2,148
acute quadriplegic myopathy 74 | 1,157
diabetes mellitus 74 | 1,663
Cancer 72 | 2,346
astrocytic glioma 68 | 2,241
interstitial cystitis 68 | 2,299
ductal carcinoma in situ 61 | 1,745
breast carcinoma 60 | 1,614
medulloblastoma 59 | 1,524
group 3 medulloblastoma 56 | 2,254
dermatomyositis 55 | 933
juvenile dermatomyositis 55 | 1,189
pituitary cancer 55 | 1,972
spina bifida 51 | 1,064
tuberculosis 51 | 1,557
posterior fossa group A ependymoma 50 | 1,511
primary pancreatic ductal adenocarcinoma 50 | 1,271
adrenocortical carcinoma 49 | 1,427
sonic hedgehog group medulloblastoma 49 | 1,482
ulcerative colitis 49 | 2,087
Rheumatoid Arthritis 47 | 1,160
cystic fibrosis 46 | 1,665
posterior fossa group B ependymoma 46 | 1,530
colon cancer 44 | 1,475
Waldenstrons macroglobulinemia 40 | 765
Neurodegenerative disease 37 | 383
Alzheimer's disease 36 | 644
tuberculosis and treatment for 6 months 36 | 686
cutaneous lupus erythematosus 35 | 1,056
non primary Sjogren syndrome sicca 33 | 840
Atopic dermatitis 32 | 944
gastric carcinoma 30 | 832
atypical teratoid/rhabdoid tumor 29 | 1,095
esophageal adenocarcinoma 29 | 737
hereditary spastic paraplegia 29 | 313
progressive supranuclear palsy 29 | 674
IGA Glomerulonephritis 28 | 454
Intellectual disability 28 | 573
acute myeloid leukemia 28 | 780
active Crohn's disease 27 | 918
aldosterone-producing adenoma 27 | 664
primary Sjogren syndrome 27 | 789
Down syndrome 24 | 548
pancreatic carcinoma 23 | 567
Duchenne muscular dystrophy 22 | 602
hepatocellular carcinoma 22 | 532
Amyotrophic Lateral Sclerosis 21 | 431
Parkinson's disease 21 | 364
Epilepsy 20 | 346
Neuropathy 20 | 210
Obesity 20 | 616
mucosa-associated lymphoid tissue lymphoma 20 | 480
nasopharyngeal carcinoma 20 | 1,056
Endometriosis 19 | 535
Prostatic Neoplasms 19 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 499
Heart disease 18 | 279
Polycystic Ovary Syndrome 18 | 332
Schizophrenia 18 | 501
gastric cancer 18 | 430
Gaucher disease type 1 17 | 171
Hermansky-Pudlak syndrome 17 | 43
Kidney disease 17 | 396
Microcephaly 15 | 149
fibroadenoma 15 | 557
inflammatory breast cancer 15 | 404
Vascular disease 14 | 281
tuberculosis and treatment for 3 months 14 | 327
Bipolar Disorder 13 | 266
Paraplegia 13 | 71
Stomach Neoplasms 13 | 282

Tissue

Endocrine System 602 | 18,512
Nervous System 602 | 18,561
Urinary Tract 602 | 18,444
Digestive Tract 601 | 18,473
Female tissues 601 | 18,647
Blood and immune system 600 | 17,995
Liver and Pancreas 600 | 18,136
Cardiovascular System 599 | 17,958
Male tissues 599 | 17,969
Skin and soft tissues 598 | 18,115
Respiratory system 595 | 17,484

Target Family

Non-IDG 477 | 11,971
Enzyme 102 | 4,146
Kinase 16 | 634
GPCR 6 | 406
Transporter 3 | 473
Ion Channel 2 | 341
Transcription Factor 2 | 1,400

Reactome Pathway

Membrane Trafficking 608 | 608
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Tether containing UBX domain for GLUT4 ASPSCR1 Tbio Non-IDG -3.18322 1605.1 195
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A ANKRD28 Tbio Enzyme -0.56847 4.64 67
Protein DENND6B DENND6B Tbio Non-IDG 0.90 0.11 29