Development Level

Tbio 36 | 11,445
Tdark 9 | 6,588
Tchem 5 | 1,598
Tclin 1 | 613

IMPC Phenotype

male infertility 3 | 123
female infertility 2 | 60
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal spleen morphology 1 | 55
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
increased body temperature 1 | 9
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 27 | 11,493
ovarian cancer 25 | 8,520
psoriasis 23 | 6,694
Breast cancer 22 | 3,578
lung cancer 19 | 4,740
Cancer 16 | 2,499
atypical teratoid / rhabdoid tumor 14 | 5,112
glioblastoma 14 | 5,792
group 3 medulloblastoma 13 | 4,104
lung adenocarcinoma 13 | 2,716
malignant mesothelioma 13 | 3,232
osteosarcoma 13 | 7,950
invasive ductal carcinoma 12 | 2,951
breast carcinoma 11 | 1,638
ductal carcinoma in situ 11 | 1,745
medulloblastoma, large-cell 11 | 6,241
non-small cell lung cancer 11 | 2,890
colon cancer 10 | 1,478
Autosomal recessive predisposition 9 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
primitive neuroectodermal tumor 8 | 3,035
Ataxia telangiectasia 7 | 34
Breast Neoplasms 7 | 445
Chromosome Breakage 7 | 36
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Intellectual disability 7 | 1,016
Kidney cancer 7 | 2,613
Male infertility 7 | 206
Mammary Neoplasms 7 | 425
Short stature 7 | 531
Small head 7 | 374
adult high grade glioma 7 | 3,801
cystic fibrosis 7 | 1,696
ependymoma 7 | 4,679
nasopharyngeal carcinoma 7 | 1,058
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Multiple myeloma 6 | 1,332
Nijmegen breakage syndrome 6 | 24
Poor school performance 6 | 645
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
Astrocytoma, Pilocytic 5 | 3,081
Fanconi anemia 5 | 56
Increased chromosomal breakage 5 | 27
Prostatic Neoplasms 5 | 495
Waldenstrons macroglobulinemia 5 | 765
Xeroderma pigmentosum 5 | 43
cutaneous lupus erythematosus 5 | 1,057
lung carcinoma 5 | 2,843
Cleft Palate 4 | 271
Decreased platelet count 4 | 111
Liver cancer 4 | 604
Lynch syndrome 4 | 35
Malignant neoplasm of breast 4 | 15
Ovarian Neoplasms 4 | 102
Premature ovarian failure 4 | 65
Schizophrenia 4 | 1,160
Thrombocytopenia 4 | 197
Werner syndrome 4 | 29
non-small cell lung carcinoma 4 | 317
ovarian neoplasm 4 | 99
Abdominal Pain 3 | 98
Acquired scoliosis 3 | 281
Anemia 3 | 365
Attention deficit hyperactivity disorder 3 | 278
Azoospermia 3 | 110
Cognitive delay 3 | 608
Connective tissue disease 3 | 62
Constipation 3 | 181
Curvature of spine 3 | 282
Delayed bone age 3 | 136
Depressive disorder 3 | 409
Dyschezia 3 | 135
Endometrial cancer 3 | 311
Endometriosis 3 | 540
Hyperplasia of nose 3 | 23
Hypertrophy of nose 3 | 23
Intrauterine retardation 3 | 176
Large nose 3 | 23
Leukopenia 3 | 72
Lupus erythematosus 3 | 57
Lymphoma 3 | 81
Mental and motor retardation 3 | 608
Microcephaly 3 | 166
Nausea and vomiting 3 | 97
Prostate cancer 3 | 175
Short palpebral fissure 3 | 38
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
gastric cancer 3 | 459
hypopigmented skin patch 3 | 59
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
medulloblastoma 3 | 720
pancreatic carcinoma 3 | 562
posterior fossa group A ependymoma 3 | 468

Tissue

Endocrine System 51 | 18,159
Blood and immune system 49 | 16,909
Female tissues 49 | 17,400
Skin and soft tissues 49 | 17,230
Liver and Pancreas 48 | 16,750
Nervous System 48 | 16,725
Urinary Tract 48 | 16,678
Digestive Tract 47 | 17,369
Male tissues 47 | 17,142
Respiratory system 46 | 16,393
Cardiovascular System 45 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634
TF/Epigenetic 1 | 38

Reactome Pathway

Meiotic recombination 51 | 51
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Testis-expressed protein 15 TEX15 Tbio Non-IDG -1.05372 9.87 11
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133