Development Level

Tbio 57 | 10,625
Tdark 17 | 7,003
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Term

male infertility 3 | 62
preweaning lethality, complete... 3 | 633
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
female infertility 2 | 34
increased heart weight 2 | 37
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal spleen morphology 1 | 36
cataract 1 | 26
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
hydrops fetalis 1 | 22
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
microphthalmia 1 | 15
preweaning lethality, incomple... 1 | 260
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
small testis 1 | 37

Disease

ovarian cancer 43 | 8,484
psoriasis 36 | 6,685
osteosarcoma 31 | 7,933
lung cancer 30 | 4,466
Breast cancer 27 | 3,094
glioblastoma 25 | 5,572
malignant mesothelioma 24 | 3,162
medulloblastoma, large-cell 23 | 6,234
Cancer 21 | 2,346
primitive neuroectodermal tumor 19 | 3,031
atypical teratoid / rhabdoid tumor 17 | 4,369
invasive ductal carcinoma 17 | 2,950
lung adenocarcinoma 17 | 2,713
Carcinoma 16 | 2,147
ductal carcinoma in situ 15 | 1,745
non-small cell lung cancer 15 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
oligodendroglioma 14 | 2,849
colon cancer 13 | 1,475
group 3 medulloblastoma 12 | 2,254
pediatric high grade glioma 12 | 2,712
Male infertility 11 | 170
atypical teratoid/rhabdoid tumor 11 | 1,095
pilocytic astrocytoma 11 | 3,086
sonic hedgehog group medulloblastoma 11 | 1,482
Multiple myeloma 10 | 1,327
breast carcinoma 10 | 1,614
ependymoma 10 | 2,514
posterior fossa group A ependymoma 10 | 1,511
Mammary Neoplasms 9 | 410
Neoplastic Syndromes, Hereditary 9 | 48
cystic fibrosis 9 | 1,665
lung carcinoma 9 | 2,844
nasopharyngeal carcinoma 9 | 1,056
pancreatic cancer 9 | 2,300
subependymal giant cell astrocytoma 9 | 2,287
Ataxia telangiectasia 8 | 31
Infertility 8 | 163
Nijmegen breakage syndrome 8 | 23
Pick disease 8 | 1,893
Waldenstrons macroglobulinemia 8 | 765
pituitary cancer 8 | 1,972
Prostatic Neoplasms 7 | 471
astrocytoma 7 | 1,493
cutaneous lupus erythematosus 7 | 1,056
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
Emery-Dreifuss muscular dystrophy 6 | 24
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Intellectual disability 6 | 573
Rheumatoid Arthritis 6 | 1,160
Werner syndrome 6 | 29
acute quadriplegic myopathy 6 | 1,157
dermatomyositis 6 | 933
diabetes mellitus 6 | 1,663
medulloblastoma 6 | 1,524
pancreatic carcinoma 6 | 567
Chronic Lymphocytic Leukemia 5 | 242
Fanconi's anemia 5 | 50
Melanoma 5 | 261
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
gastric cancer 5 | 430
non-small cell lung carcinoma 5 | 413
progressive supranuclear palsy 5 | 674
ulcerative colitis 5 | 2,087
Anemia 4 | 252
Bladder Neoplasm 4 | 109
Bloom syndrome 4 | 30
Breast Cancer, Familial 4 | 12
Cornelia de Lange syndrome 4 | 21
Down syndrome 4 | 548
Endometriosis 4 | 535
Lynch syndrome 4 | 33
Malignant neoplasm of breast 4 | 63
Microcephaly 4 | 149
Myeloid Leukemia 4 | 19
Pancreatic Neoplasm 4 | 79
Progeria 4 | 22
Seckel syndrome 4 | 34
interstitial cystitis 4 | 2,299
ovarian neoplasm 4 | 97
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group B ependymoma 4 | 1,530
tuberculosis and treatment for 6 months 4 | 686
Atopic dermatitis 3 | 944
IGA Glomerulonephritis 3 | 454
Leishmaniasis 3 | 49
Peripheral Neuropathy 3 | 303
Prostate cancer 3 | 172
acute myeloid leukemia 3 | 780
aldosterone-producing adenoma 3 | 664
gastric carcinoma 3 | 832
hepatocellular carcinoma 3 | 532
inflammatory breast cancer 3 | 404
juvenile dermatomyositis 3 | 1,189
spina bifida 3 | 1,064
tuberculosis 3 | 1,557

Tissue

Female tissues 83 | 18,647
Endocrine System 82 | 18,512
Male tissues 82 | 17,969
Nervous System 82 | 18,561
Urinary Tract 82 | 18,444
Blood and immune system 81 | 17,995
Cardiovascular System 81 | 17,958
Digestive Tract 81 | 18,473
Liver and Pancreas 80 | 18,136
Respiratory system 79 | 17,484
Skin and soft tissues 75 | 18,115

Target Family

Non-IDG 72 | 11,971
Kinase 4 | 634
Enzyme 3 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Reactome Pathway

Meiosis 83 | 83
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Structural maintenance of chromosomes protein 1B SMC1B Tbio Non-IDG -1.26509 19.6 93
Synaptonemal complex protein 3 SYCP3 Tbio Non-IDG -2.15623 144.9 251
Synaptonemal complex central element protein 3 SYCE3 Tdark Non-IDG -0.73316 6.63 5
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.05162 104.9 234
MutS protein homolog 4 MSH4 Tbio Non-IDG -1.85039 70.8 78
SUN domain-containing protein 1 SUN1 Tbio Non-IDG -1.65634 48.2 53
Nesprin-2 SYNE2 Tbio Non-IDG -2.51721 337.2 32