Development Level

Tbio 57 | 10,625
Tdark 17 | 7,003
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Phenotype

male infertility 3 | 62
preweaning lethality, complete... 3 | 633
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
female infertility 2 | 34
increased heart weight 2 | 37
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat-hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal spleen morphology 1 | 36
cataract 1 | 26
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
hydrops fetalis 1 | 22
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
microphthalmia 1 | 15
preweaning lethality, incomple... 1 | 260
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
small testis 1 | 37

Disease

ovarian cancer 45 | 8,491
psoriasis 36 | 6,685
osteosarcoma 31 | 7,933
lung cancer 30 | 4,473
Breast cancer 27 | 3,098
glioblastoma 25 | 5,572
malignant mesothelioma 24 | 3,163
medulloblastoma, large-cell 23 | 6,234
Cancer 21 | 2,346
primitive neuroectodermal tumor 19 | 3,031
atypical teratoid / rhabdoid tumor 17 | 4,369
invasive ductal carcinoma 17 | 2,950
lung adenocarcinoma 17 | 2,714
Carcinoma 16 | 2,147
ductal carcinoma in situ 15 | 1,745
non-small cell lung cancer 15 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
oligodendroglioma 14 | 2,849
colon cancer 13 | 1,475
group 3 medulloblastoma 12 | 2,254
pediatric high grade glioma 12 | 2,712
Male infertility 11 | 170
atypical teratoid/rhabdoid tumor 11 | 1,095
pilocytic astrocytoma 11 | 3,086
sonic hedgehog group medulloblastoma 11 | 1,482
Multiple myeloma 10 | 1,327
breast carcinoma 10 | 1,614
ependymoma 10 | 2,514
posterior fossa group A ependymoma 10 | 1,511
Mammary Neoplasms 9 | 410
Neoplastic Syndromes, Hereditary 9 | 48
cystic fibrosis 9 | 1,670
lung carcinoma 9 | 2,844
nasopharyngeal carcinoma 9 | 1,056
pancreatic cancer 9 | 2,300
subependymal giant cell astrocytoma 9 | 2,287
Ataxia telangiectasia 8 | 32
Infertility 8 | 163
Nijmegen breakage syndrome 8 | 23
Pick disease 8 | 1,893
Waldenstrons macroglobulinemia 8 | 764
pituitary cancer 8 | 1,972
Prostatic Neoplasms 7 | 471
astrocytoma 7 | 1,493
cutaneous lupus erythematosus 7 | 1,056
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
Emery-Dreifuss muscular dystrophy 6 | 24
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Intellectual disability 6 | 573
Rheumatoid Arthritis 6 | 1,170
Werner syndrome 6 | 29
acute quadriplegic myopathy 6 | 1,157
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,663
medulloblastoma 6 | 1,524
pancreatic carcinoma 6 | 567
Fanconi's anemia 5 | 50
Melanoma 5 | 261
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
chronic lymphocytic leukemia 5 | 244
gastric cancer 5 | 436
non-small cell lung carcinoma 5 | 413
progressive supranuclear palsy 5 | 674
ulcerative colitis 5 | 2,087
Anemia 4 | 252
Bladder Neoplasm 4 | 109
Bloom syndrome 4 | 30
Breast Cancer, Familial 4 | 12
Cornelia de Lange syndrome 4 | 21
Down syndrome 4 | 548
Endometriosis 4 | 535
Lynch syndrome 4 | 35
Malignant neoplasm of breast 4 | 63
Microcephaly 4 | 149
Myeloid Leukemia 4 | 19
Pancreatic Neoplasm 4 | 79
Progeria 4 | 22
Seckel syndrome 4 | 35
hepatocellular carcinoma 4 | 550
interstitial cystitis 4 | 2,299
ovarian neoplasm 4 | 97
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group B ependymoma 4 | 1,530
tuberculosis and treatment for 6 months 4 | 686
Atopic dermatitis 3 | 944
IGA Glomerulonephritis 3 | 454
Leishmaniasis 3 | 49
Peripheral Neuropathy 3 | 303
Prostate cancer 3 | 172
acute myeloid leukemia 3 | 785
aldosterone-producing adenoma 3 | 664
gastric carcinoma 3 | 832
inflammatory breast cancer 3 | 404
juvenile dermatomyositis 3 | 1,189
spina bifida 3 | 1,064
tuberculosis 3 | 1,563

Tissue

Female tissues 83 | 18,646
Endocrine System 82 | 18,511
Male tissues 82 | 17,968
Nervous System 82 | 18,560
Urinary Tract 82 | 18,443
Blood and immune system 81 | 17,994
Cardiovascular System 81 | 17,957
Digestive Tract 81 | 18,472
Liver and Pancreas 80 | 18,135
Respiratory system 79 | 17,483
Skin and soft tissues 75 | 18,114

Target Family

Non-IDG 72 | 11,969
Kinase 4 | 634
Enzyme 3 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Reactome Pathway

Meiosis 83 | 83
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Testis-expressed sequence 12 protein TEX12 Tdark Non-IDG -0.49336 2.83 70
Testis-expressed sequence 15 protein TEX15 Tdark Non-IDG -1.02645 7.66 6
Structural maintenance of chromosomes protein 1B SMC1B Tbio Non-IDG -1.29693 19.6 93
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.74218 5.60 257