Development Level

Tbio 56 | 11,445
Tchem 6 | 1,598
Tdark 4 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 5 | 239
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating serum al... 1 | 22
increased glycosylated hemoglo... 1 | 1
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
thrombocytopenia 1 | 56

Disease

ovarian cancer 41 | 8,520
Carcinoma 34 | 11,493
osteosarcoma 30 | 7,950
medulloblastoma, large-cell 27 | 6,241
psoriasis 24 | 6,694
Cancer 16 | 2,499
lung cancer 16 | 4,740
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
Multiple myeloma 12 | 1,332
Breast cancer 11 | 3,578
adult high grade glioma 11 | 3,801
subependymal giant cell astrocytoma 10 | 2,287
Kidney cancer 9 | 2,613
ependymoma 9 | 4,679
malignant mesothelioma 8 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
spina bifida 7 | 1,074
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
Intellectual disability 5 | 1,016
Pick disease 5 | 1,894
Renal Cell Carcinoma 5 | 214
Schizophrenia 5 | 1,160
Vici syndrome 5 | 14
hepatocellular carcinoma 5 | 547
primitive neuroectodermal tumor 5 | 3,035
Angiomyolipoma 4 | 18
Autistic Disorder 4 | 364
Centronuclear myopathy 4 | 27
Kidney angiomyolipoma 4 | 8
Lymphangioleiomyomatosis 4 | 16
Neurodegenerative disease 4 | 414
Ovarian Neoplasms 4 | 102
Vascular disease 4 | 319
Waldenstrons macroglobulinemia 4 | 765
Wolff-Parkinson-White syndrome 4 | 19
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
tuberculosis and treatment for 6 months 4 | 409
Anemia 3 | 365
Astrocytoma, Pilocytic 3 | 3,081
Attention deficit hyperactivity disorder 3 | 278
Birt-Hogg-Dube syndrome 3 | 11
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Dyspnea 3 | 76
Epilepsy 3 | 792
Focal cortical dysplasia of Taylor 3 | 3
Global developmental delay 3 | 608
Granulomatous amebic encephalitis 3 | 8
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Nerve Degeneration 3 | 121
Poor school performance 3 | 645
Tuberous sclerosis 3 | 19
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
gastric cancer 3 | 459
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
Abdominal Pain 2 | 98
Adult onset 2 | 82
Breast Neoplasms 2 | 445
Cardiomyopathies 2 | 110
Chemical and Drug Induced Liver Injury 2 | 195
Chest Pain 2 | 38
Globe disease 2 | 67
Lethargy 2 | 77
Lymphadenopathy 2 | 62
Lymphopenia 2 | 67
Mammary Neoplasms 2 | 425
Necrosis 2 | 53
Neuro-degenerative disease 2 | 43
Neurodegeneration with brain iron accumulation 5 2 | 9
Neurodegenerative Disorders 2 | 79
Prominent back of the head 2 | 21
Prominent occiput 2 | 21
Specific learning disability 2 | 47
Squamous cell carcinoma 2 | 129
Weight decreased 2 | 103
West Syndrome 2 | 28

Tissue

Digestive Tract 66 | 17,369
Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Skin and soft tissues 66 | 17,230
Blood and immune system 65 | 16,909
Cardiovascular System 65 | 15,192
Liver and Pancreas 65 | 16,750
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678

Target Family

Non-IDG 48 | 12,091
Enzyme 10 | 4,145
Kinase 8 | 634
Transporter 1 | 473

Reactome Pathway

Macroautophagy 67 | 67
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Charged multivesicular body protein 7 CHMP7 Tbio Non-IDG -0.61033 3.61 30
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Charged multivesicular body protein 3 CHMP3 Tbio Non-IDG -1.39658 35.6 64
Cysteine protease ATG4A ATG4A Tbio Enzyme -1.07944 9.29 261
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
Gamma-aminobutyric acid receptor-associated protein-like 1 GABARAPL1 Tbio Non-IDG -2.39692 232.7 211
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.71624 54.4 193
Sodium-coupled neutral amino acid transporter 9 SLC38A9 Tbio Transporter -0.82795 8.59 27
Gamma-aminobutyric acid receptor-associated protein-like 3 GABARAPL3 Tdark Non-IDG -0.16137 0.12 0