Development Level

Tbio 88 | 11,651
Tchem 20 | 1,388
Tdark 11 | 6,593

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased total body fat amoun... 4 | 207
decreased circulating choleste... 3 | 93
impaired glucose tolerance 3 | 75
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal seminal vesicle morph... 2 | 114
absent pinna reflex 2 | 23
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating free fat... 2 | 31
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased circulating free fat... 2 | 20
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
abnormal cecum morphology 1 | 7
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal stomach morphology 1 | 10
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
premature death 1 | 5

Disease

ovarian cancer 71 | 8,520
Carcinoma 66 | 11,493
glioblastoma 55 | 5,792
osteosarcoma 44 | 7,950
lung cancer 42 | 4,740
psoriasis 42 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
adult high grade glioma 39 | 3,801
medulloblastoma, large-cell 39 | 6,241
lung carcinoma 33 | 2,843
ependymoma 32 | 4,679
invasive ductal carcinoma 31 | 2,951
Breast cancer 29 | 3,578
Rheumatoid arthritis 29 | 1,191
diabetes mellitus 29 | 1,728
non-small cell lung cancer 29 | 2,890
Astrocytoma, Pilocytic 28 | 3,081
malignant mesothelioma 28 | 3,232
group 3 medulloblastoma 26 | 4,104
subependymal giant cell astrocytoma 26 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
breast carcinoma 24 | 1,638
adrenocortical carcinoma 23 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
pancreatic cancer 21 | 2,398
primitive neuroectodermal tumor 20 | 3,035
lung adenocarcinoma 19 | 2,716
Narcolepsy 18 | 72
astrocytoma 18 | 1,146
interstitial cystitis 18 | 2,312
oligodendroglioma 18 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
tuberculosis 17 | 2,010
Atopic dermatitis 16 | 952
Cancer 16 | 2,499
juvenile dermatomyositis 16 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Berylliosis 15 | 28
Duchenne muscular dystrophy 15 | 601
Kidney cancer 15 | 2,613
Narcolepsy-cataplexy 15 | 21
active Crohn's disease 15 | 922
colon cancer 15 | 1,478
primary Sjogren syndrome 15 | 735
sarcoidosis 15 | 370
Multiple Sclerosis, Susceptibility to 14 | 15
Systemic lupus erythematosus 14 | 194
cutaneous lupus erythematosus 14 | 1,057
ductal carcinoma in situ 14 | 1,745
pituitary cancer 14 | 1,972
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
acute quadriplegic myopathy 13 | 1,158
follicular lymphoma 13 | 20
limited scleroderma 13 | 19
Autosomal recessive predisposition 12 | 1,442
Multiple Sclerosis 12 | 540
Multiple myeloma 12 | 1,332
Pick disease 12 | 1,894
active ulcerative colitis 12 | 764
astrocytic glioma 12 | 2,597
cystic fibrosis 12 | 1,696
esophageal adenocarcinoma 12 | 737
ulcerative colitis 12 | 1,819
Endometriosis 11 | 540
Waldenstrons macroglobulinemia 10 | 765
dermatomyositis 10 | 966
Epilepsy 9 | 792
Neurodegenerative disease 9 | 414
group 4 medulloblastoma 9 | 1,855
Intellectual disability 8 | 1,016
Muscle hypotonia 8 | 571
Schizophrenia 8 | 1,160
Seizures 8 | 596
Type 1 diabetes mellitus 8 | 109
acute myeloid leukemia 8 | 783
spina bifida 8 | 1,074
Bipolar Disorder 7 | 666
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Hypersensitivity reaction type II disease 7 | 253
Juvenile rheumatoid arthritis 7 | 111
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Neuropathy 7 | 261
Poor school performance 7 | 645
nasopharyngeal carcinoma 7 | 1,058
Becker muscular dystrophy 6 | 191
Down syndrome 6 | 499
Short stature 6 | 531
Small head 6 | 374
gastric carcinoma 6 | 807
nephrosclerosis 6 | 333
non primary Sjogren syndrome sicca 6 | 891
pancreatic carcinoma 6 | 562
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Endocrine System 103 | 18,159
Liver and Pancreas 102 | 16,750
Skin and soft tissues 102 | 17,230
Blood and immune system 101 | 16,909
Digestive Tract 101 | 17,369
Female tissues 101 | 17,400
Male tissues 101 | 17,142
Respiratory system 101 | 16,393
Urinary Tract 101 | 16,678
Cardiovascular System 97 | 15,192
Nervous System 96 | 16,725

Target Family

Non-IDG 101 | 12,091
Enzyme 18 | 4,145

Reactome Pathway

MHC class II antigen presentat... 119 | 119
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Cathepsin E CTSE Tchem Enzyme -2.33724 227.7 192
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
AP-1 complex subunit mu-2 AP1M2 Tbio Non-IDG -2.54240 341.5 68
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Dynactin subunit 4 DCTN4 Tbio Non-IDG -0.85019 7.19 160
Dynactin subunit 5 DCTN5 Tdark Non-IDG -0.32495 0.71 53
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Kinesin-like protein KIF22 KIF22 Tbio Non-IDG -1.69996 54.3 147