Development Level

Tbio 79 | 10,625
Tchem 25 | 1,890
Tdark 11 | 7,003

IMPC Term

preweaning lethality, complete... 8 | 633
decreased total body fat amoun... 6 | 186
short tibia 4 | 82
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
absent pinna reflex 2 | 21
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating free fat... 2 | 39
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating free fat... 2 | 17
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
cataract 1 | 26
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD4-... 1 | 6
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
premature death 1 | 5
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26

Disease

ovarian cancer 68 | 8,484
glioblastoma 53 | 5,572
osteosarcoma 44 | 7,933
lung cancer 39 | 4,466
medulloblastoma, large-cell 38 | 6,234
psoriasis 38 | 6,685
atypical teratoid / rhabdoid tumor 35 | 4,369
lung carcinoma 33 | 2,844
invasive ductal carcinoma 31 | 2,950
non-small cell lung cancer 29 | 2,798
diabetes mellitus 28 | 1,663
malignant mesothelioma 28 | 3,162
pilocytic astrocytoma 28 | 3,086
pediatric high grade glioma 26 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
subependymal giant cell astrocytoma 25 | 2,287
breast carcinoma 24 | 1,614
adrenocortical carcinoma 23 | 1,427
astrocytoma 23 | 1,493
Breast cancer 22 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
pancreatic cancer 20 | 2,300
primitive neuroectodermal tumor 20 | 3,031
lung adenocarcinoma 19 | 2,713
posterior fossa group A ependymoma 19 | 1,511
adult high grade glioma 18 | 2,148
interstitial cystitis 18 | 2,299
oligodendroglioma 18 | 2,849
Rheumatoid Arthritis 17 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
primary Sjogren syndrome 17 | 789
Atopic dermatitis 16 | 944
Cancer 16 | 2,346
active Crohn's disease 15 | 918
colon cancer 15 | 1,475
juvenile dermatomyositis 15 | 1,189
ulcerative colitis 15 | 2,087
Duchenne muscular dystrophy 14 | 602
cutaneous lupus erythematosus 14 | 1,056
ductal carcinoma in situ 14 | 1,745
pituitary cancer 14 | 1,972
tuberculosis 14 | 1,557
ependymoma 13 | 2,514
IGA Glomerulonephritis 12 | 454
Pick disease 12 | 1,893
acute quadriplegic myopathy 12 | 1,157
cystic fibrosis 12 | 1,665
esophageal adenocarcinoma 12 | 737
group 4 medulloblastoma 12 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
sonic hedgehog group medulloblastoma 12 | 1,482
Endometriosis 11 | 535
Multiple Sclerosis 11 | 498
Multiple myeloma 11 | 1,327
dermatomyositis 11 | 933
group 3 medulloblastoma 11 | 2,254
Carcinoma 10 | 2,147
Neurodegenerative disease 9 | 383
Waldenstrons macroglobulinemia 9 | 765
active ulcerative colitis 9 | 477
primary pancreatic ductal adenocarcinoma 9 | 1,271
Narcolepsy 8 | 58
Type 1 diabetes mellitus 8 | 101
acute myeloid leukemia 8 | 780
posterior fossa group B ependymoma 8 | 1,530
Alzheimer's disease 7 | 644
Hypersensitivity reaction type II disease 7 | 235
atypical teratoid/rhabdoid tumor 7 | 1,095
medulloblastoma 7 | 1,524
nasopharyngeal carcinoma 7 | 1,056
spina bifida 7 | 1,064
Asthma 6 | 349
Chronic hepatitis C 6 | 12
Down syndrome 6 | 548
Juvenile rheumatoid arthritis 6 | 104
Neuropathy 6 | 210
astrocytic glioma 6 | 2,241
gastric carcinoma 6 | 832
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
nephrosclerosis 6 | 329
pancreatic carcinoma 6 | 567
Becker muscular dystrophy 5 | 187
Diabetes Mellitus, Insulin-Dependent 5 | 76
Hepatitis B, Chronic 5 | 15
Hypersensitivity 5 | 63
Microcephaly 5 | 149
Paraplegia 5 | 71
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
limb girdle muscular dystrophy 2I 5 | 56
mucosa-associated lymphoid tissue lymphoma 5 | 480
sarcoidosis 5 | 358
tuberculosis and treatment for 6 months 5 | 686
Amyotrophic Lateral Sclerosis 4 | 431
Parkinson's disease 4 | 364
Vascular disease 4 | 281
hepatocellular carcinoma 4 | 532
non-small cell lung carcinoma 4 | 413
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 3 months 4 | 327

Tissue

Blood and immune system 105 | 17,995
Digestive Tract 105 | 18,473
Endocrine System 105 | 18,512
Female tissues 105 | 18,647
Liver and Pancreas 105 | 18,136
Male tissues 105 | 17,969
Nervous System 105 | 18,561
Urinary Tract 105 | 18,444
Cardiovascular System 104 | 17,958
Respiratory system 104 | 17,484
Skin and soft tissues 100 | 18,115

Target Family

Non-IDG 97 | 11,971
Enzyme 18 | 4,146

Reactome Pathway

MHC class II antigen presentat... 115 | 115
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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