Development Level

Tbio 79 | 10,625
Tchem 25 | 1,890
Tdark 11 | 7,003

IMPC Phenotype

preweaning lethality, complete... 8 | 633
decreased total body fat amoun... 6 | 186
short tibia 4 | 82
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
absent pinna reflex 2 | 21
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating free fat... 2 | 39
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating free fat... 2 | 17
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
cataract 1 | 26
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD4-... 1 | 6
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
premature death 1 | 5
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26

Disease

ovarian cancer 68 | 8,491
glioblastoma 53 | 5,572
osteosarcoma 44 | 7,933
lung cancer 39 | 4,473
medulloblastoma, large-cell 38 | 6,234
psoriasis 38 | 6,685
atypical teratoid / rhabdoid tumor 35 | 4,369
lung carcinoma 33 | 2,844
invasive ductal carcinoma 31 | 2,950
non-small cell lung cancer 29 | 2,798
diabetes mellitus 28 | 1,663
malignant mesothelioma 28 | 3,163
pilocytic astrocytoma 28 | 3,086
Rheumatoid Arthritis 27 | 1,170
pediatric high grade glioma 26 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
subependymal giant cell astrocytoma 25 | 2,287
breast carcinoma 24 | 1,614
adrenocortical carcinoma 23 | 1,427
astrocytoma 23 | 1,493
Breast cancer 22 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
pancreatic cancer 20 | 2,300
primitive neuroectodermal tumor 20 | 3,031
lung adenocarcinoma 19 | 2,714
posterior fossa group A ependymoma 19 | 1,511
Narcolepsy 18 | 69
adult high grade glioma 18 | 2,148
interstitial cystitis 18 | 2,299
oligodendroglioma 18 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
primary Sjogren syndrome 17 | 788
Atopic dermatitis 16 | 944
Cancer 16 | 2,346
Berylliosis 15 | 28
Narcolepsy-cataplexy 15 | 21
active Crohn's disease 15 | 918
colon cancer 15 | 1,475
juvenile dermatomyositis 15 | 1,189
sarcoidosis 15 | 368
ulcerative colitis 15 | 2,087
Duchenne muscular dystrophy 14 | 602
Multiple Sclerosis, Susceptibility to 14 | 15
cutaneous lupus erythematosus 14 | 1,056
ductal carcinoma in situ 14 | 1,745
pituitary cancer 14 | 1,972
systemic lupus erythematosus 14 | 172
tuberculosis 14 | 1,563
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
ependymoma 13 | 2,514
follicular lymphoma 13 | 17
limited scleroderma 13 | 19
IGA Glomerulonephritis 12 | 454
Pick disease 12 | 1,893
acute quadriplegic myopathy 12 | 1,157
cystic fibrosis 12 | 1,670
esophageal adenocarcinoma 12 | 737
group 4 medulloblastoma 12 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
sonic hedgehog group medulloblastoma 12 | 1,482
Endometriosis 11 | 535
Multiple Sclerosis 11 | 498
Multiple myeloma 11 | 1,327
dermatomyositis 11 | 966
group 3 medulloblastoma 11 | 2,254
Carcinoma 10 | 2,147
Neurodegenerative disease 9 | 383
Waldenstrons macroglobulinemia 9 | 764
active ulcerative colitis 9 | 477
primary pancreatic ductal adenocarcinoma 9 | 1,271
Type 1 diabetes mellitus 8 | 104
acute myeloid leukemia 8 | 785
posterior fossa group B ependymoma 8 | 1,530
Alzheimer's disease 7 | 644
Hypersensitivity reaction type II disease 7 | 235
atypical teratoid/rhabdoid tumor 7 | 1,095
medulloblastoma 7 | 1,524
nasopharyngeal carcinoma 7 | 1,056
spina bifida 7 | 1,064
Asthma 6 | 349
Chronic hepatitis C 6 | 12
Down syndrome 6 | 548
Juvenile rheumatoid arthritis 6 | 105
Neuropathy 6 | 210
astrocytic glioma 6 | 2,241
gastric carcinoma 6 | 832
head and neck cancer and chronic obstructive pulmonary disease 6 | 237
nephrosclerosis 6 | 329
pancreatic carcinoma 6 | 567
Becker muscular dystrophy 5 | 187
Hypersensitivity 5 | 63
Microcephaly 5 | 149
Paraplegia 5 | 71
hereditary spastic paraplegia 5 | 313
inflammatory breast cancer 5 | 404
limb girdle muscular dystrophy 2I 5 | 56
mucosa-associated lymphoid tissue lymphoma 5 | 480
tuberculosis and treatment for 6 months 5 | 686

Tissue

Blood and immune system 105 | 17,994
Digestive Tract 105 | 18,472
Endocrine System 105 | 18,511
Female tissues 105 | 18,646
Liver and Pancreas 105 | 18,135
Male tissues 105 | 17,968
Nervous System 105 | 18,560
Urinary Tract 105 | 18,443
Cardiovascular System 104 | 17,957
Respiratory system 104 | 17,483
Skin and soft tissues 100 | 18,114

Target Family

Non-IDG 97 | 11,969
Enzyme 18 | 4,146

Reactome Pathway

MHC class II antigen presentat... 115 | 115
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.24582 1740.5 143
Dynamin-3 DNM3 Tbio Non-IDG -1.39919 21.9 126
Kinesin-like protein KIF11 KIF11 Tchem Non-IDG -2.57588 377.6 296
Oxysterol-binding protein-related protein 1 OSBPL1A Tbio Non-IDG -0.52465 3.58 131
AP-1 complex subunit mu-1 AP1M1 Tbio Non-IDG -1.18893 12.9 104
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.73539 525.6 142
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.63101 403.7 216
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.90682 75.1 192
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.39116 24.9 96
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.63705 36.3 159