Development Level

Tbio 20 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal skin morphology 2 | 50
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal femur morphology 1 | 14
abnormal retina morphology 1 | 71
abnormal tooth morphology 1 | 24
decreased circulating choleste... 1 | 93
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 25 | 11,493
ovarian cancer 20 | 8,520
Kidney cancer 17 | 2,613
Breast cancer 16 | 3,578
osteosarcoma 14 | 7,950
ependymoma 13 | 4,679
pancreatic cancer 13 | 2,398
Cancer 12 | 2,499
glioblastoma 12 | 5,792
invasive ductal carcinoma 12 | 2,951
non-small cell lung cancer 12 | 2,890
psoriasis 12 | 6,694
lung cancer 11 | 4,740
malignant mesothelioma 11 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung carcinoma 10 | 2,843
Autosomal recessive predisposition 9 | 1,442
atypical teratoid / rhabdoid tumor 9 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
medulloblastoma, large-cell 9 | 6,241
breast carcinoma 8 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
ulcerative colitis 8 | 1,819
Astrocytoma, Pilocytic 7 | 3,081
Liver cancer 7 | 604
cystic fibrosis 7 | 1,696
primary pancreatic ductal adenocarcinoma 7 | 1,109
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
pediatric high grade glioma 6 | 1,064
subependymal giant cell astrocytoma 6 | 2,287
Duchenne muscular dystrophy 5 | 601
Failure to gain weight 5 | 365
Feeding difficulties 5 | 127
Hypodontia 5 | 81
Melanoma 5 | 711
Muscle hypotonia 5 | 571
Neoplasm Invasiveness 5 | 161
Pediatric failure to thrive 5 | 365
Prenatal onset 5 | 139
Schizophrenia 5 | 1,160
Skin cancer 5 | 469
active ulcerative colitis 5 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primitive neuroectodermal tumor 5 | 3,035
Carcinoma, Hepatocellular 4 | 228
Carcinoma, Squamous Cell 4 | 110
Epidermolysis bullosa 4 | 21
Liver carcinoma 4 | 240
Myopia 4 | 176
Neoplasm Metastasis 4 | 168
Small head 4 | 374
Squamous cell carcinoma 4 | 129
Vascular disease 4 | 319
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 807
medulloblastoma 4 | 720
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung carcinoma 4 | 317
tuberculosis 4 | 2,010
Abnormal blistering of the skin 3 | 54
Age related macular degeneration 1 3 | 4
Anemia 3 | 365
Barrett's esophagus 3 | 182
Blister of skin 3 | 54
Cardiomyopathy, Dilated 3 | 83
Death in early childhood 3 | 82
Death in infancy 3 | 82
Dyspnea 3 | 76
Dystrophia unguium 3 | 53
Endometriosis 3 | 540
Epilepsy 3 | 792
Flexion contracture of proximal interphalangeal joint 3 | 75
Hemoglobin low 3 | 124
Junctional epidermolysis bullosa 3 | 7
Kidney disease 3 | 430
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Liver Cirrhosis, Experimental 3 | 769
Macrotia 3 | 87
Nail dysplasia 3 | 52
Pyloric Stenosis 3 | 47
Skin bulla 3 | 54
Strabismus 3 | 270

Tissue

Blood and immune system 28 | 16,909
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Cardiovascular System 26 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 4 | 4,145
Kinase 3 | 634

Reactome Pathway

MET promotes cell motility 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Laminin subunit gamma-1 LAMC1 Tbio Non-IDG -1.79184 56.7 318
Tensin-3 TNS3 Tbio Non-IDG -2.06381 115.1 78
Dedicator of cytokinesis protein 7 DOCK7 Tbio Non-IDG -1.21382 17.1 63
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452