Development Level

Tbio 16 | 10,625
Tchem 10 | 1,890
Tclin 3 | 602

IMPC Phenotype

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal coat-hair pigmentatio... 1 | 54
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased cervical vertebrae n... 1 | 12
enlarged heart 1 | 111
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased NK T cell number 1 | 11
increased startle reflex 1 | 38
persistence of hyaloid vascula... 1 | 22
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 21 | 8,491
Carcinoma 16 | 2,147
osteosarcoma 15 | 7,933
Breast cancer 14 | 3,098
Cancer 13 | 2,346
psoriasis 13 | 6,685
invasive ductal carcinoma 12 | 2,950
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
glioblastoma 10 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
lung cancer 10 | 4,473
lung carcinoma 10 | 2,844
pediatric high grade glioma 10 | 2,712
primary pancreatic ductal adenocarcinoma 10 | 1,271
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
malignant mesothelioma 9 | 3,163
medulloblastoma, large-cell 9 | 6,234
ulcerative colitis 9 | 2,087
atypical teratoid / rhabdoid tumor 8 | 4,369
breast carcinoma 8 | 1,614
group 4 medulloblastoma 8 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
lung adenocarcinoma 8 | 2,714
oligodendroglioma 8 | 2,849
cystic fibrosis 7 | 1,670
pilocytic astrocytoma 7 | 3,086
sonic hedgehog group medulloblastoma 7 | 1,482
ependymoma 6 | 2,514
juvenile dermatomyositis 6 | 1,189
posterior fossa group A ependymoma 6 | 1,511
subependymal giant cell astrocytoma 6 | 2,287
Duchenne muscular dystrophy 5 | 602
Neoplasm Invasiveness 5 | 127
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
colon cancer 5 | 1,475
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,299
primitive neuroectodermal tumor 5 | 3,031
Epidermolysis bullosa 4 | 21
Junctional epidermolysis bullosa 4 | 9
Liver carcinoma 4 | 217
Schizophrenia 4 | 503
Squamous cell carcinoma 4 | 96
active ulcerative colitis 4 | 477
acute quadriplegic myopathy 4 | 1,157
astrocytoma 4 | 1,493
diabetes mellitus 4 | 1,663
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 832
glioblastoma multiforme 4 | 347
nasopharyngeal carcinoma 4 | 1,056
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung carcinoma 4 | 413
tuberculosis 4 | 1,563
Adult junctional epidermolysis bullosa (disorder) 3 | 5
Barrett's esophagus 3 | 185
Endometriosis 3 | 535
Epidermolysis bullosa, junctional, Herlitz type 3 | 3
Galloway-Mowat syndrome 3 | 9
Herlitz Disease 3 | 3
Kidney disease 3 | 397
Lissencephaly 3 | 61
Multiple myeloma 3 | 1,327
Myopia 3 | 99
Neoplasm Metastasis 3 | 138
Rheumatoid Arthritis 3 | 1,170
Vascular disease 3 | 281
astrocytic glioma 3 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
Adult junctional epidermolysis bullosa 2 | 3
Arthritis 2 | 248
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
COPD 2 | 116
Cardiomyopathies 2 | 90
Cardiovascular system disease 2 | 194
Colorectal Cancer 2 | 62
Epilepsy 2 | 346
Generalized junctional epidermolysis bullosa, non-Herlitz type 2 | 3
Heart failure 2 | 80
Intellectual disability 2 | 573
Kabuki syndrome 2 | 29
Leukemia, Myelocytic, Acute 2 | 113
Liver disease 2 | 219
Myocardial Ischemia 2 | 169
Neuroblastoma 2 | 78
Nonsyndromic deafness 2 | 121
Osteoporosis 2 | 259
Pick disease 2 | 1,893
Prostatic Neoplasms 2 | 471
Waldenstrons macroglobulinemia 2 | 764
adrenocortical carcinoma 2 | 1,427
fibroadenoma 2 | 557
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674
spina bifida 2 | 1,064

Tissue

Blood and immune system 29 | 17,994
Cardiovascular System 29 | 17,957
Digestive Tract 29 | 18,472
Endocrine System 29 | 18,511
Female tissues 29 | 18,646
Liver and Pancreas 29 | 18,135
Male tissues 29 | 17,968
Nervous System 29 | 18,560
Respiratory system 29 | 17,483
Skin and soft tissues 29 | 18,114
Urinary Tract 29 | 18,443

Target Family

Non-IDG 22 | 11,969
Enzyme 4 | 4,146
Kinase 3 | 634

Reactome Pathway

MET promotes cell motility 29 | 29
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hepatocyte growth factor HGF Tchem Enzyme -3.29371 2317.3 573
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.36614 248.3 109
Integrin alpha-2 ITGA2 Tbio Non-IDG -4.08943 11813.0 639
Laminin subunit beta-1 LAMB1 Tbio Non-IDG -1.91389 76.8 243
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -3.98540 8801.0 1257
Adapter molecule crk CRK Tchem Non-IDG -2.52859 335.5 405
Crk-like protein CRKL Tbio Non-IDG -2.18286 151.1 430
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.00519 933.5 424
Tensin-4 TNS4 Tbio Non-IDG -1.17092 13.6 124