Development Level

Tbio 6 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
urinary bladder obstruction 1 | 4

Disease

glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
ovarian cancer 6 | 8,520
Breast cancer 5 | 3,578
Carcinoma 5 | 11,493
primitive neuroectodermal tumor 5 | 3,035
psoriasis 5 | 6,694
Cancer 4 | 2,499
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
osteosarcoma 4 | 7,950
subependymal giant cell astrocytoma 4 | 2,287
Endometriosis 3 | 540
Multiple myeloma 3 | 1,332
Waldenstrons macroglobulinemia 3 | 765
breast carcinoma 3 | 1,638
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung cancer 3 | 4,740
nasopharyngeal carcinoma 3 | 1,058
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Myocardial Ischemia 2 | 169
colon cancer 2 | 1,478
malignant mesothelioma 2 | 3,232
oligodendroglioma 2 | 2,850
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Abnormal hair whorls 1 | 5
Anteverted nostril 1 | 191
Asthma 1 | 385
Asymmetry of the posterior cranium 1 | 20
Autosomal recessive predisposition 1 | 1,442
Broad hallux 1 | 29
Bronchioloalveolar Adenocarcinoma 1 | 14
Degenerative polyarthritis 1 | 115
Delayed myelination 1 | 22
Diffuse large B-cell lymphoma 1 | 39
Dilated ventricles (finding) 1 | 121
Disease Progression 1 | 136
Downward slant of palpebral fissure 1 | 158
Dull intelligence 1 | 645
Endometrial cancer 1 | 311
Epilepsy 1 | 792
Facial asymmetry 1 | 32
Flattening of cranial vault 1 | 20
Flattening of head 1 | 20
Gross motor development delay 1 | 21
Heart Diseases 1 | 43
Hypoplasia of corpus callosum 1 | 90
Inverted V-shaped upper lip 1 | 19
Kidney cancer 1 | 2,613
Liver Cirrhosis, Experimental 1 | 769
Lung Neoplasms 1 | 232
Lymphoma, Large B-Cell, Diffuse 1 | 34
Mental and motor retardation 1 | 608
Neuronal ceroid lipofuscinosis 1 | 28
Open mouth 1 | 45
Osteoarthritis 1 | 184
Pasteurellosis 1 | 12
Pectus excavatum 1 | 100
Plagiocephaly 1 | 20
Plagiocephaly, Nonsynostotic 1 | 20
Polycystic ovary syndrome 1 | 360
Prominent metopic ridge 1 | 15
Range of joint movement increased 1 | 32
Rheumatoid arthritis 1 | 1,191
Rhomboid shaped head 1 | 20
Seizures 1 | 596
Stomach Neoplasms 1 | 300
Tented mouth 1 | 19
Tented upper lip 1 | 19
Type 2 diabetes mellitus 1 | 272
Usher syndrome type 1C 1 | 3
Werner syndrome 1 | 29
aldosterone-producing adenoma 1 | 665
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 559
hereditary spastic paraplegia 1 | 318
interstitial cystitis 1 | 2,312
lung carcinoma 1 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pediatric high grade glioma 1 | 1,064
posterior fossa group A ependymoma 1 | 468
tuberculosis 1 | 2,010

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Enzyme 5 | 4,145
Kinase 2 | 634
Non-IDG 2 | 12,091

Reactome Pathway

MASTL Facilitates Mitotic Prog... 9 | 9
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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