Development Level

Tbio 68 | 11,651
Tchem 15 | 1,388
Tclin 5 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal retina morphology 2 | 71
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal kidney morphology 1 | 65
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating creatine... 1 | 5
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart rate 1 | 23
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

ovarian cancer 62 | 8,520
Carcinoma 51 | 11,493
osteosarcoma 46 | 7,950
psoriasis 43 | 6,694
lung cancer 40 | 4,740
glioblastoma 35 | 5,792
Multiple myeloma 34 | 1,332
Cancer 26 | 2,499
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 24 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Breast cancer 22 | 3,578
oligodendroglioma 21 | 2,850
malignant mesothelioma 20 | 3,232
astrocytic glioma 19 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pancreatic cancer 18 | 2,398
HIV Infections 17 | 102
Pick disease 17 | 1,894
Waldenstrons macroglobulinemia 17 | 765
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
adult high grade glioma 14 | 3,801
dermatomyositis 14 | 966
non-small cell lung cancer 14 | 2,890
primitive neuroectodermal tumor 14 | 3,035
diabetes mellitus 13 | 1,728
invasive ductal carcinoma 13 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
tuberculosis 13 | 2,010
Astrocytoma, Pilocytic 12 | 3,081
astrocytoma 12 | 1,146
group 4 medulloblastoma 12 | 1,855
subependymal giant cell astrocytoma 12 | 2,287
Rheumatoid arthritis 11 | 1,191
acute quadriplegic myopathy 10 | 1,158
lung carcinoma 10 | 2,843
primary pancreatic ductal adenocarcinoma 10 | 1,109
juvenile dermatomyositis 9 | 1,187
lung adenocarcinoma 9 | 2,716
ulcerative colitis 9 | 1,819
Alzheimer's disease 8 | 658
Kidney cancer 8 | 2,613
Vascular disease 8 | 319
breast carcinoma 8 | 1,638
progressive supranuclear palsy 8 | 676
Liver Cirrhosis, Experimental 7 | 769
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
non primary Sjogren syndrome sicca 7 | 891
pituitary cancer 7 | 1,972
Anemia 6 | 365
Autosomal recessive predisposition 6 | 1,442
Endometriosis 6 | 540
Osteoporosis 6 | 363
Schizophrenia 6 | 1,160
acute myeloid leukemia 6 | 783
cutaneous lupus erythematosus 6 | 1,057
hepatocellular carcinoma 6 | 547
interstitial cystitis 6 | 2,312
primary Sjogren syndrome 6 | 735
spina bifida 6 | 1,074
Breast Neoplasms 5 | 445
Carcinoma, Hepatocellular 5 | 228
Duchenne muscular dystrophy 5 | 601
Liver carcinoma 5 | 240
Mammary Neoplasms 5 | 425
Mantle cell lymphoma 5 | 23
Neoplasm Metastasis 5 | 168
Parkinson's disease 5 | 392
adrenocortical carcinoma 5 | 1,428
ductal carcinoma in situ 5 | 1,745
esophageal adenocarcinoma 5 | 737
gastric cancer 5 | 459
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
Arthritis 4 | 290
Carcinoma, Squamous Cell 4 | 110
Down syndrome 4 | 499
Obesity 4 | 678
Prostatic Neoplasms 4 | 495
Stomach Neoplasms 4 | 300
aldosterone-producing adenoma 4 | 665
chronic rhinosinusitis 4 | 512
pancreatic carcinoma 4 | 562
sarcoidosis 4 | 370
Atopic dermatitis 3 | 952
Bipolar Disorder 3 | 666
Contact Dermatitis 3 | 81
Dermatitis, Contact 3 | 71
Failure to gain weight 3 | 365
Hemoglobin low 3 | 124
Hepatomegaly 3 | 285
Liver neoplasms 3 | 130
Lung Neoplasms 3 | 232
Multiple Sclerosis 3 | 540
Pediatric failure to thrive 3 | 365
active Crohn's disease 3 | 922
nasopharyngeal carcinoma 3 | 1,058

Tissue

Endocrine System 90 | 18,159
Blood and immune system 88 | 16,909
Male tissues 88 | 17,142
Urinary Tract 88 | 16,678
Digestive Tract 87 | 17,369
Female tissues 87 | 17,400
Liver and Pancreas 86 | 16,750
Nervous System 86 | 16,725
Respiratory system 86 | 16,393
Skin and soft tissues 85 | 17,230
Cardiovascular System 84 | 15,192

Target Family

Enzyme 45 | 4,145
Non-IDG 28 | 12,091
Kinase 11 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

Reactome Pathway

MAPK6/MAPK4 signaling 91 | 91
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Cdc42 effector protein 3 CDC42EP3 Tbio Non-IDG -1.57638 37.5 124
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Trinucleotide repeat-containing gene 6C protein TNRC6C Tbio Non-IDG -0.67756 3.07 30
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168