Development Level

Tbio 56 | 10,625
Tchem 28 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased grip strength 1 | 83
increased heart rate 1 | 17
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
prolonged QRS complex duration 1 | 2
shortened RR interval 1 | 19
thrombocytopenia 1 | 46

Disease

ovarian cancer 62 | 8,484
osteosarcoma 45 | 7,933
psoriasis 43 | 6,685
lung cancer 39 | 4,466
Multiple myeloma 34 | 1,327
glioblastoma 34 | 5,572
Cancer 26 | 2,346
medulloblastoma, large-cell 26 | 6,234
atypical teratoid / rhabdoid tumor 24 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
oligodendroglioma 21 | 2,849
Breast cancer 20 | 3,094
malignant mesothelioma 20 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
Pick disease 18 | 1,893
pancreatic cancer 18 | 2,300
HIV Infections 17 | 100
Waldenstrons macroglobulinemia 17 | 765
astrocytic glioma 17 | 2,241
ependymoma 17 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
pediatric high grade glioma 16 | 2,712
astrocytoma 14 | 1,493
dermatomyositis 14 | 933
primitive neuroectodermal tumor 14 | 3,031
invasive ductal carcinoma 13 | 2,950
diabetes mellitus 12 | 1,663
non-small cell lung cancer 12 | 2,798
pilocytic astrocytoma 12 | 3,086
primary pancreatic ductal adenocarcinoma 12 | 1,271
medulloblastoma 11 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
subependymal giant cell astrocytoma 11 | 2,287
Rheumatoid Arthritis 10 | 1,160
acute quadriplegic myopathy 10 | 1,157
group 3 medulloblastoma 10 | 2,254
group 4 medulloblastoma 10 | 1,875
lung carcinoma 10 | 2,844
ulcerative colitis 10 | 2,087
juvenile dermatomyositis 9 | 1,189
lung adenocarcinoma 9 | 2,713
breast carcinoma 8 | 1,614
progressive supranuclear palsy 8 | 674
tuberculosis 8 | 1,557
Alzheimer's disease 7 | 644
Carcinoma 7 | 2,147
Vascular disease 7 | 281
colon cancer 7 | 1,475
cystic fibrosis 7 | 1,665
non primary Sjogren syndrome sicca 7 | 840
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
Endometriosis 6 | 535
cutaneous lupus erythematosus 6 | 1,056
hepatocellular carcinoma 6 | 532
interstitial cystitis 6 | 2,299
primary Sjogren syndrome 6 | 789
spina bifida 6 | 1,064
Duchenne muscular dystrophy 5 | 602
Liver carcinoma 5 | 217
Mammary Neoplasms 5 | 410
Mantle cell lymphoma 5 | 18
Parkinson's disease 5 | 364
acute myeloid leukemia 5 | 780
adrenocortical carcinoma 5 | 1,427
ductal carcinoma in situ 5 | 1,745
esophageal adenocarcinoma 5 | 737
gastric cancer 5 | 430
Down syndrome 4 | 548
Neoplasm Metastasis 4 | 138
Obesity 4 | 616
Prostatic Neoplasms 4 | 471
Stomach Neoplasms 4 | 282
aldosterone-producing adenoma 4 | 664
chronic rhinosinusitis 4 | 512
inflammatory breast cancer 4 | 404
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
sarcoidosis 4 | 358
tuberculosis and treatment for 6 months 4 | 686
Amyotrophic Lateral Sclerosis 3 | 431
Animal Mammary Neoplasms 3 | 136
Atopic dermatitis 3 | 944
Chronic Lymphocytic Leukemia 3 | 242
Colonic Neoplasms 3 | 126
Contact Dermatitis 3 | 80
Crohn's disease 3 | 304
IGA Glomerulonephritis 3 | 454
Leukemia, Myelocytic, Acute 3 | 113
Liver neoplasms 3 | 109
Lung Neoplasms 3 | 171
Mammary Neoplasms, Experimental 3 | 150
Neoplastic Cell Transformation 3 | 81
Peripheral Neuropathy 3 | 303
Renal Cell Carcinoma 3 | 199
Schizophrenia 3 | 501
active Crohn's disease 3 | 918
adult high grade glioma 3 | 2,148
nasopharyngeal carcinoma 3 | 1,056
sonic hedgehog group medulloblastoma 3 | 1,482

Tissue

Blood and immune system 90 | 17,995
Endocrine System 90 | 18,512
Female tissues 90 | 18,647
Liver and Pancreas 90 | 18,136
Male tissues 90 | 17,969
Nervous System 90 | 18,561
Urinary Tract 90 | 18,444
Digestive Tract 89 | 18,473
Cardiovascular System 88 | 17,958
Respiratory system 88 | 17,484
Skin and soft tissues 88 | 18,115

Target Family

Enzyme 45 | 4,146
Non-IDG 27 | 11,971
Kinase 11 | 634
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

Reactome Pathway

MAPK6/MAPK4 signaling 90 | 90
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
DnaJ homolog subfamily B member 1 DNAJB1 Tbio Non-IDG -2.60383 367.9 470
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.83653 71.4 158
MAP kinase-activated protein kinase 5 MAPKAPK5 Tchem Kinase -1.83621 77.3 377
26S protease regulatory subunit 8 PSMC5 Tbio Enzyme -1.68576 49.6 167