Development Level

Tbio 183 | 11,445
Tchem 49 | 1,598
Tclin 45 | 613
Tdark 8 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 23 | 979
decreased body weight 9 | 161
abnormal bone structure 8 | 187
decreased total body fat amoun... 8 | 207
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
short tibia 7 | 97
embryonic lethality prior to t... 6 | 278
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
hypoactivity 5 | 132
decreased circulating HDL chol... 4 | 68
male infertility 4 | 123
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
female infertility 3 | 60
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
thrombocytopenia 3 | 56
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased lactate dehydrogenas... 2 | 16
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
impaired pupillary reflex 2 | 26
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating sodium l... 2 | 71
increased heart rate 2 | 23
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating creatine... 1 | 4
decreased circulating potassiu... 1 | 20
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased hematocrit 1 | 46
iris synechia 1 | 3
limb grasping 1 | 41
prenatal lethality 1 | 28
shortened RR interval 1 | 17
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 194 | 11,493
ovarian cancer 162 | 8,520
osteosarcoma 156 | 7,950
glioblastoma 128 | 5,792
Cancer 123 | 2,499
psoriasis 122 | 6,694
lung cancer 121 | 4,740
medulloblastoma, large-cell 115 | 6,241
atypical teratoid / rhabdoid tumor 101 | 5,112
ependymoma 94 | 4,679
Breast cancer 92 | 3,578
malignant mesothelioma 83 | 3,232
oligodendroglioma 76 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 72 | 3,291
adult high grade glioma 71 | 3,801
astrocytic glioma 71 | 2,597
group 3 medulloblastoma 71 | 4,104
Kidney cancer 69 | 2,613
Astrocytoma, Pilocytic 64 | 3,081
invasive ductal carcinoma 63 | 2,951
Multiple myeloma 58 | 1,332
Schizophrenia 57 | 1,160
non-small cell lung cancer 57 | 2,890
pancreatic cancer 57 | 2,398
lung adenocarcinoma 56 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
lung carcinoma 54 | 2,843
subependymal giant cell astrocytoma 53 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 52 | 2,989
tuberculosis 52 | 2,010
interstitial cystitis 50 | 2,312
primitive neuroectodermal tumor 50 | 3,035
Pick disease 45 | 1,894
ulcerative colitis 45 | 1,819
Rheumatoid arthritis 43 | 1,191
diabetes mellitus 42 | 1,728
group 4 medulloblastoma 42 | 1,855
pituitary cancer 39 | 1,972
cystic fibrosis 38 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,962
Autosomal recessive predisposition 37 | 1,442
breast carcinoma 37 | 1,638
ductal carcinoma in situ 34 | 1,745
astrocytoma 33 | 1,146
Bipolar Disorder 32 | 666
colon cancer 31 | 1,478
Liver Cirrhosis, Experimental 29 | 769
primary pancreatic ductal adenocarcinoma 29 | 1,109
Waldenstrons macroglobulinemia 28 | 765
Breast Neoplasms 27 | 445
Depressive disorder 27 | 409
Mammary Neoplasms 27 | 425
Melanoma 26 | 711
juvenile dermatomyositis 26 | 1,187
Intellectual disability 25 | 1,016
Stomach Neoplasms 25 | 300
dermatomyositis 24 | 966
spina bifida 24 | 1,074
Osteoporosis 23 | 363
Parkinson's disease 23 | 392
Alzheimer's disease 22 | 658
Carcinoma, Hepatocellular 22 | 228
Epilepsy 22 | 792
Liver carcinoma 22 | 240
Lung Neoplasms 22 | 232
Renal Cell Carcinoma 22 | 214
adrenocortical carcinoma 22 | 1,428
Anemia 21 | 365
Downward slant of palpebral fissure 21 | 158
Major Depressive Disorder 21 | 301
Mental Depression 21 | 333
Short stature 21 | 531
Skin cancer 21 | 469
Vascular disease 21 | 319
cutaneous lupus erythematosus 21 | 1,057
Orbital separation excessive 20 | 244
Prostatic Neoplasms 20 | 495
Seizures 20 | 596
Cryptorchidism 19 | 296
Dull intelligence 19 | 645
HIV Infections 19 | 102
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Poor school performance 19 | 645
Unipolar Depression 19 | 250
acute quadriplegic myopathy 19 | 1,158
esophageal adenocarcinoma 19 | 737
Hepatomegaly 18 | 285
Muscle hypotonia 18 | 571
pediatric high grade glioma 18 | 1,064
Blepharoptosis 17 | 231
Cognitive delay 17 | 608
Down syndrome 17 | 499
Global developmental delay 17 | 608
Lymphoid leukemia 17 | 160
Mental and motor retardation 17 | 608
Strabismus 17 | 270
hepatocellular carcinoma 17 | 547
non primary Sjogren syndrome sicca 17 | 891

Tissue

Endocrine System 282 | 18,159
Blood and immune system 277 | 16,909
Digestive Tract 276 | 17,369
Male tissues 276 | 17,142
Female tissues 275 | 17,400
Liver and Pancreas 274 | 16,750
Skin and soft tissues 274 | 17,230
Urinary Tract 274 | 16,678
Nervous System 271 | 16,725
Respiratory system 268 | 16,393
Cardiovascular System 257 | 15,192

Target Family

Non-IDG 139 | 12,091
Enzyme 86 | 4,145
Kinase 48 | 634
Ion Channel 5 | 344
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

Reactome Pathway

MAPK family signaling cascades 285 | 285
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Dual specificity protein phosphatase 9 DUSP9 Tbio Enzyme -1.15238 17.2 202
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79