Development Level

Tbio 160 | 10,625
Tchem 74 | 1,890
Tclin 44 | 602
Tdark 6 | 7,003

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
decreased body weight 8 | 174
decreased total body fat amoun... 7 | 186
abnormal bone structure 5 | 131
decreased bone mineral content 5 | 157
abnormal behavior 4 | 226
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased lean body mass 4 | 195
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
thrombocytopenia 4 | 46
abnormal embryo size 3 | 112
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
abnormal coat/hair pigmentatio... 2 | 54
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
hypoactivity 2 | 89
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
short tibia 1 | 82
sparse hair 1 | 6
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 162 | 8,484
osteosarcoma 156 | 7,933
glioblastoma 125 | 5,572
psoriasis 123 | 6,685
Cancer 119 | 2,346
medulloblastoma, large-cell 116 | 6,234
lung cancer 109 | 4,466
atypical teratoid / rhabdoid tumor 86 | 4,369
oligodendroglioma 76 | 2,849
malignant mesothelioma 74 | 3,162
Breast cancer 73 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 72 | 3,289
pilocytic astrocytoma 69 | 3,086
ependymoma 68 | 2,514
invasive ductal carcinoma 63 | 2,950
pediatric high grade glioma 63 | 2,712
Carcinoma 62 | 2,147
astrocytic glioma 61 | 2,241
Multiple myeloma 57 | 1,327
lung adenocarcinoma 57 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
lung carcinoma 54 | 2,844
pancreatic cancer 54 | 2,300
non-small cell lung cancer 53 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 52 | 2,988
subependymal giant cell astrocytoma 52 | 2,287
primitive neuroectodermal tumor 51 | 3,031
interstitial cystitis 50 | 2,299
ulcerative colitis 49 | 2,087
Pick disease 46 | 1,893
Rheumatoid Arthritis 41 | 1,160
astrocytoma 41 | 1,493
diabetes mellitus 40 | 1,663
group 3 medulloblastoma 39 | 2,254
group 4 medulloblastoma 39 | 1,875
pituitary cancer 39 | 1,972
cystic fibrosis 38 | 1,665
tuberculosis 38 | 1,557
medulloblastoma 37 | 1,524
breast carcinoma 36 | 1,614
ductal carcinoma in situ 34 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
primary pancreatic ductal adenocarcinoma 33 | 1,271
colon cancer 31 | 1,475
Waldenstrons macroglobulinemia 28 | 765
Mammary Neoplasms 27 | 410
adult high grade glioma 27 | 2,148
juvenile dermatomyositis 26 | 1,189
Schizophrenia 24 | 501
dermatomyositis 24 | 933
Parkinson's disease 23 | 364
spina bifida 23 | 1,064
adrenocortical carcinoma 22 | 1,427
non-small cell lung carcinoma 22 | 413
Liver carcinoma 21 | 217
cutaneous lupus erythematosus 21 | 1,056
Lung Neoplasms 20 | 171
Stomach Neoplasms 20 | 282
acute quadriplegic myopathy 20 | 1,157
posterior fossa group B ependymoma 20 | 1,530
Alzheimer's disease 19 | 644
HIV Infections 19 | 100
Intellectual disability 19 | 573
Prostatic Neoplasms 19 | 471
Renal Cell Carcinoma 19 | 199
esophageal adenocarcinoma 19 | 737
posterior fossa group A ependymoma 19 | 1,511
Vascular disease 18 | 281
atypical teratoid/rhabdoid tumor 18 | 1,095
gastric carcinoma 18 | 832
Down syndrome 17 | 548
non primary Sjogren syndrome sicca 17 | 840
Neoplasm Invasiveness 16 | 127
hepatocellular carcinoma 16 | 532
primary Sjogren syndrome 16 | 789
tuberculosis and treatment for 6 months 16 | 686
Animal Mammary Neoplasms 15 | 136
Asthma 15 | 349
Autistic Disorder 15 | 320
Mammary Neoplasms, Experimental 15 | 150
Osteoporosis 15 | 257
inflammatory breast cancer 15 | 404
pancreatic carcinoma 15 | 567
sonic hedgehog group medulloblastoma 15 | 1,482
Atopic dermatitis 14 | 944
Duchenne muscular dystrophy 14 | 602
Heart disease 14 | 279
Multiple Sclerosis 14 | 498
Myocardial Ischemia 14 | 169
Noonan Syndrome 14 | 33
Obesity 14 | 616
Peripheral Neuropathy 14 | 303
Polycystic Ovary Syndrome 14 | 332
fibroadenoma 14 | 557
progressive supranuclear palsy 14 | 674
Anemia 13 | 252
Crohn's disease 13 | 304
Endometriosis 13 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
gastric cancer 13 | 430

Tissue

Endocrine System 284 | 18,512
Female tissues 284 | 18,647
Nervous System 284 | 18,561
Urinary Tract 283 | 18,444
Digestive Tract 282 | 18,473
Liver and Pancreas 282 | 18,136
Blood and immune system 281 | 17,995
Skin and soft tissues 280 | 18,115
Cardiovascular System 279 | 17,958
Male tissues 279 | 17,969
Respiratory system 274 | 17,484

Target Family

Non-IDG 138 | 11,971
Enzyme 86 | 4,146
Kinase 48 | 634
Ion Channel 5 | 341
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

Reactome Pathway

MAPK family signaling cascades 284 | 284
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66