Development Level

Tbio 266 | 11,445
Tchem 36 | 1,598
Tdark 33 | 6,588
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 44 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 8 | 499
decreased body weight 6 | 161
embryonic growth retardation 6 | 106
abnormal embryo size 5 | 220
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
decreased lean body mass 5 | 135
male infertility 5 | 123
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
cataract 4 | 92
decreased body length 4 | 101
decreased total body fat amoun... 4 | 207
increased mean corpuscular vol... 4 | 92
abnormal head morphology 3 | 10
abnormal lens morphology 3 | 81
abnormal tail morphology 3 | 25
decreased bone mineral density 3 | 126
decreased circulating calcium ... 3 | 36
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
enlarged lymph nodes 3 | 37
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased fasted circulating g... 3 | 76
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal heart morphology 2 | 162
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal locomotor behavior 2 | 24
abnormal placenta morphology 2 | 5
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
absent pinna reflex 2 | 23
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased heart left ventricle... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased vertical activity 2 | 208
edema 2 | 59
impaired glucose tolerance 2 | 75
increased circulating chloride... 2 | 41
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased thermal nociceptive ... 2 | 9
microphthalmia 2 | 26
small testis 2 | 58
syndactyly 2 | 23
abnormal cornea morphology 1 | 31
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
long tibia 1 | 25
prenatal lethality 1 | 28
small kidney 1 | 16
small spleen 1 | 19
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

ovarian cancer 215 | 8,520
Carcinoma 209 | 11,493
osteosarcoma 160 | 7,950
lung cancer 155 | 4,740
medulloblastoma, large-cell 150 | 6,241
psoriasis 147 | 6,694
glioblastoma 142 | 5,792
group 3 medulloblastoma 139 | 4,104
atypical teratoid / rhabdoid tumor 132 | 5,112
Breast cancer 114 | 3,578
primitive neuroectodermal tumor 104 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 103 | 3,291
ependymoma 94 | 4,679
non-small cell lung cancer 92 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 89 | 2,989
malignant mesothelioma 89 | 3,232
adult high grade glioma 86 | 3,801
invasive ductal carcinoma 77 | 2,951
lung adenocarcinoma 70 | 2,716
Multiple myeloma 69 | 1,332
adrenocortical carcinoma 68 | 1,428
Kidney cancer 64 | 2,613
oligodendroglioma 63 | 2,850
Cancer 55 | 2,499
colon cancer 55 | 1,478
breast carcinoma 53 | 1,638
ductal carcinoma in situ 52 | 1,745
astrocytic glioma 50 | 2,597
pancreatic cancer 49 | 2,398
nasopharyngeal carcinoma 45 | 1,058
Pick disease 44 | 1,894
Waldenstrons macroglobulinemia 42 | 765
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,962
Astrocytoma, Pilocytic 40 | 3,081
Intellectual disability 40 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
Atopic dermatitis 39 | 952
dermatomyositis 37 | 966
Endometriosis 36 | 540
subependymal giant cell astrocytoma 32 | 2,287
astrocytoma 30 | 1,146
tuberculosis 29 | 2,010
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
Rheumatoid arthritis 26 | 1,191
Short stature 26 | 531
Small head 25 | 374
diabetes mellitus 25 | 1,728
group 4 medulloblastoma 25 | 1,855
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Microcephaly 24 | 166
Poor school performance 24 | 645
acute quadriplegic myopathy 24 | 1,158
ulcerative colitis 23 | 1,819
Autosomal recessive predisposition 22 | 1,442
non primary Sjogren syndrome sicca 22 | 891
pediatric high grade glioma 22 | 1,064
primary Sjogren syndrome 21 | 735
juvenile dermatomyositis 20 | 1,187
interstitial cystitis 19 | 2,312
pituitary cancer 19 | 1,972
Hypoplastic mandible condyle 18 | 275
Mandibular hypoplasia 18 | 275
Micrognathism 18 | 275
Schizophrenia 18 | 1,160
HIV Infections 17 | 102
lung carcinoma 17 | 2,843
Epilepsy 16 | 792
acute myeloid leukemia 16 | 783
progressive supranuclear palsy 16 | 676
Fetal Growth Retardation 15 | 189
Infant, Small for Gestational Age 15 | 176
Intrauterine retardation 15 | 176
Seizures 15 | 596
posterior fossa group A ependymoma 14 | 468
active Crohn's disease 13 | 922
cutaneous lupus erythematosus 13 | 1,057
spina bifida 13 | 1,074
tuberculosis and treatment for 6 months 13 | 409
Amyotrophic lateral sclerosis 12 | 451
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 807
Anteverted nostril 11 | 191
Bilateral fifth finger clinodactyly 11 | 110
Curvature of little finger 11 | 110
Downward slant of palpebral fissure 11 | 158
Glaucoma 11 | 239
Liver Cirrhosis, Experimental 11 | 769
Obesity 11 | 678
cystic fibrosis 11 | 1,696
pancreatic carcinoma 11 | 562
Cataract 10 | 297
Cleft Palate 10 | 271
Failure to gain weight 10 | 365
Orbital separation excessive 10 | 244
Pediatric failure to thrive 10 | 365

Tissue

Endocrine System 341 | 18,159
Blood and immune system 338 | 16,909
Digestive Tract 338 | 17,369
Female tissues 338 | 17,400
Male tissues 337 | 17,142
Nervous System 337 | 16,725
Respiratory system 337 | 16,393
Skin and soft tissues 337 | 17,230
Urinary Tract 337 | 16,678
Liver and Pancreas 336 | 16,750
Cardiovascular System 332 | 15,192

Target Family

Non-IDG 241 | 12,091
Enzyme 76 | 4,145
Kinase 24 | 634
Epigenetic 3 | 242

Reactome Pathway

M Phase 344 | 344
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Condensin-2 complex subunit G2 NCAPG2 Tbio Non-IDG -0.75957 5.48 110
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178