Development Level

Tbio 69 | 11,651
Tclin 7 | 612
Tchem 5 | 1,388
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 2 | 220
decreased caudal vertebrae num... 2 | 53
increased mean corpuscular vol... 2 | 92
abnormal behavioral response t... 1 | 66
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
increased grip strength 1 | 41
increased heart weight 1 | 62
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 59 | 8,520
lung cancer 44 | 4,740
psoriasis 39 | 6,694
Carcinoma 38 | 11,493
glioblastoma 34 | 5,792
osteosarcoma 34 | 7,950
Multiple myeloma 31 | 1,332
group 3 medulloblastoma 31 | 4,104
malignant mesothelioma 31 | 3,232
medulloblastoma, large-cell 28 | 6,241
non-small cell lung cancer 28 | 2,890
Breast cancer 24 | 3,578
Cancer 22 | 2,499
atypical teratoid / rhabdoid tumor 21 | 5,112
adrenocortical carcinoma 18 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
primitive neuroectodermal tumor 18 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Waldenstrons macroglobulinemia 16 | 765
lung adenocarcinoma 16 | 2,716
HIV Infections 15 | 102
adult high grade glioma 14 | 3,801
invasive ductal carcinoma 14 | 2,951
dermatomyositis 13 | 966
ependymoma 13 | 4,679
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
nasopharyngeal carcinoma 11 | 1,058
oligodendroglioma 10 | 2,850
Autosomal recessive predisposition 8 | 1,442
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary Sjogren syndrome 8 | 735
Atopic dermatitis 7 | 952
Meier-Gorlin syndrome 7 | 10
diabetes mellitus 7 | 1,728
non primary Sjogren syndrome sicca 7 | 891
pancreatic cancer 7 | 2,398
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 7
Endometriosis 6 | 540
Seckel syndrome 6 | 34
pediatric high grade glioma 6 | 1,064
subependymal giant cell astrocytoma 6 | 2,287
Failure to gain weight 5 | 365
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Isolated growth hormone deficiency 5 | 30
Mantle cell lymphoma 5 | 23
Pediatric failure to thrive 5 | 365
Pick disease 5 | 1,894
Small head 5 | 374
breast carcinoma 5 | 1,638
esophageal adenocarcinoma 5 | 737
lung carcinoma 5 | 2,843
Birth length less than 3rd percentile 4 | 6
Congenital small ears 4 | 48
Cryptorchidism 4 | 296
Delayed bone age 4 | 136
Hypoplastic mandible condyle 4 | 275
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Osteoporosis 4 | 363
Slender, gracile long tubular bones 4 | 21
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
ulcerative colitis 4 | 1,819
Anemia 3 | 365
Congenital hypoplasia of breast 3 | 25
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Feeding difficulties 3 | 127
Full lower lip 3 | 64
Gastroesophageal reflux disease 3 | 110
Heartburn 3 | 78
Hypertrophy of clitoris 3 | 40
Hypoplasia of the maxilla 3 | 66
Hypotrophic maxilla 3 | 66
Intellectual disability 3 | 1,016
Maxillary retrognathia 3 | 66
Microcephaly 3 | 166
Microstomia 3 | 78
Polycystic ovary syndrome 3 | 360
Prominent lower lip 3 | 64
Retrusion of upper jaw bones 3 | 66
Rheumatoid arthritis 3 | 1,191
active Crohn's disease 3 | 922
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
hepatocellular carcinoma 2 | 547
pituitary cancer 2 | 1,972

Tissue

Endocrine System 84 | 18,159
Blood and immune system 83 | 16,909
Digestive Tract 83 | 17,369
Female tissues 83 | 17,400
Male tissues 83 | 17,142
Nervous System 83 | 16,725
Respiratory system 83 | 16,393
Urinary Tract 83 | 16,678
Liver and Pancreas 82 | 16,750
Skin and soft tissues 82 | 17,230
Cardiovascular System 80 | 15,192

Target Family

Enzyme 48 | 4,145
Non-IDG 32 | 12,091
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

M/G1 Transition 85 | 85
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305