Development Level

Tbio 54 | 10,625
Tchem 21 | 1,890
Tclin 7 | 602
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 2 | 148
abnormal lens morphology 1 | 73
cataract 1 | 26
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
embryonic lethality prior to t... 1 | 187
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 60 | 8,484
lung cancer 44 | 4,466
psoriasis 40 | 6,685
osteosarcoma 35 | 7,933
glioblastoma 33 | 5,572
malignant mesothelioma 32 | 3,162
Multiple myeloma 31 | 1,327
medulloblastoma, large-cell 29 | 6,234
non-small cell lung cancer 28 | 2,798
group 3 medulloblastoma 24 | 2,254
Cancer 22 | 2,346
Breast cancer 21 | 3,094
adrenocortical carcinoma 19 | 1,427
primitive neuroectodermal tumor 19 | 3,031
atypical teratoid / rhabdoid tumor 18 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
pediatric high grade glioma 18 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung adenocarcinoma 17 | 2,713
Waldenstrons macroglobulinemia 16 | 765
HIV Infections 15 | 100
invasive ductal carcinoma 15 | 2,950
dermatomyositis 13 | 933
posterior fossa group A ependymoma 12 | 1,511
astrocytoma 11 | 1,493
colon cancer 11 | 1,475
nasopharyngeal carcinoma 11 | 1,056
oligodendroglioma 10 | 2,849
ductal carcinoma in situ 9 | 1,745
Meier-Gorlin syndrome 8 | 12
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
primary Sjogren syndrome 8 | 789
Atopic dermatitis 7 | 944
diabetes mellitus 7 | 1,663
non primary Sjogren syndrome sicca 7 | 840
pancreatic cancer 7 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 6
Endometriosis 6 | 535
Seckel syndrome 6 | 34
pilocytic astrocytoma 6 | 3,086
Mantle cell lymphoma 5 | 18
Pick disease 5 | 1,893
atypical teratoid/rhabdoid tumor 5 | 1,095
breast carcinoma 5 | 1,614
esophageal adenocarcinoma 5 | 737
inflammatory breast cancer 5 | 404
lung carcinoma 5 | 2,844
sonic hedgehog group medulloblastoma 5 | 1,482
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 1,557
ulcerative colitis 5 | 2,087
acute myeloid leukemia 4 | 780
astrocytic glioma 4 | 2,241
interstitial cystitis 4 | 2,299
juvenile dermatomyositis 4 | 1,189
primary pancreatic ductal adenocarcinoma 4 | 1,271
IGA Glomerulonephritis 3 | 454
Microcephaly 3 | 149
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 332
Rheumatoid Arthritis 3 | 1,160
active Crohn's disease 3 | 918
adult high grade glioma 3 | 2,148
cutaneous lupus erythematosus 3 | 1,056
ependymoma 3 | 2,514
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
medulloblastoma 3 | 1,524
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Alzheimer's disease 2 | 644
Animal Mammary Neoplasms 2 | 136
Cervix endometriosis 2 | 3
DiGeorge syndrome 2 | 46
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Mammary Neoplasms, Experimental 2 | 150
Melanoma 2 | 261
Meningeal Leukemia 2 | 7
Menopause present (finding) 2 | 20
Metastatic Breast Carcinoma 2 | 21
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Osteoporosis 2 | 257
Pick's disease 2 | 14
Pulmonary emphysema 2 | 34
Rothmund-Thomson syndrome 2 | 22
Squamous cell carcinoma of esophagus 2 | 82
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,665
gastric cancer 2 | 430
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 532
pituitary cancer 2 | 1,972
substance-related disorder 2 | 105

Tissue

Blood and immune system 84 | 17,995
Digestive Tract 84 | 18,473
Endocrine System 84 | 18,512
Female tissues 84 | 18,647
Liver and Pancreas 84 | 18,136
Male tissues 84 | 17,969
Nervous System 84 | 18,561
Urinary Tract 84 | 18,444
Cardiovascular System 83 | 17,958
Respiratory system 83 | 17,484
Skin and soft tissues 83 | 18,115

Target Family

Enzyme 48 | 4,146
Non-IDG 31 | 11,971
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

M/G1 Transition 84 | 84
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76
DNA primase small subunit PRIM1 Tbio Enzyme -0.88906 8.05 121
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.49781 32.5 130
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50789 31.4 61
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225