Development Level

Tbio 10 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

decreased total body fat amoun... 2 | 207
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal mandible morphology 1 | 2
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating potassiu... 1 | 20
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 6 | 11,493
Autosomal recessive predisposition 5 | 1,442
Muscle hypotonia 5 | 571
ovarian cancer 5 | 8,520
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
psoriasis 4 | 6,694
Cognitive delay 3 | 608
Epilepsy 3 | 792
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Metabolic acidosis 3 | 90
astrocytic glioma 3 | 2,597
oligodendroglioma 3 | 2,850
osteosarcoma 3 | 7,950
Astrocytoma, Pilocytic 2 | 3,081
Breast cancer 2 | 3,578
Cerebellar Ataxia 2 | 304
Chronic obstructive pulmonary disease 2 | 184
Delayed speech and language development 2 | 112
Dull intelligence 2 | 645
Dystonia 2 | 164
Dystonic disease 2 | 106
Electroencephalogram abnormal 2 | 101
Encephalopathies 2 | 43
Hypoglycemia 2 | 152
Intellectual disability 2 | 1,016
Language Delay 2 | 112
Little's Disease 2 | 14
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Movement Disorders 2 | 55
Orotic aciduria 2 | 18
Poor school performance 2 | 645
Seizures 2 | 596
Short stature 2 | 531
Speech Delay 2 | 112
Speech impairment 2 | 112
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
cystic fibrosis 2 | 1,696
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
nephrosclerosis 2 | 333
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
Abnormality of metabolism/homeostasis 1 | 134
Ankylosing spondylitis 1 | 140
Big calvaria 1 | 147
Citrullinemia 1 | 14
Coloboma 1 | 51
Corneal dystrophy 1 | 24
Cystinuria 1 | 18
Death in childhood 1 | 14
Delayed myelination 1 | 22
Dilation of lateral ventricles 1 | 4
Ectopia Lentis 1 | 17
Epilepsies, Myoclonic 1 | 32
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Facioscapulohumeral muscular dystrophy 1 | 26
Generalized myoclonic seizures 1 | 30
Hyperactive behavior 1 | 91
Hypertrophic Cardiomyopathy 1 | 117
Impotence 1 | 42
Increased head circumference 1 | 147
Increased serum lactate 1 | 60
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Irritation - emotion 1 | 68
Ketonemia 1 | 11
Ketosis 1 | 11
Leigh disease 1 | 100
Lethargy 1 | 77
Mild Mental Retardation 1 | 70
Muscle Rigidity 1 | 49
Myoclonic Epilepsies, Progressive 1 | 44
Nicotine dependence 1 | 54
Nonsyndromic deafness 1 | 142
Organic acidemia 1 | 4
Ornithine translocase deficiency 1 | 7
Osteoporosis 1 | 363
Pseudoxanthoma elasticum 1 | 18
Psoriatic arthritis 1 | 86
Respiratory Distress Syndrome 1 | 15
Respiratory distress 1 | 43
Reye syndrome 1 | 11
Sensorineural Hearing Loss (disorder) 1 | 284
Succinic semialdehyde dehydrogenase deficiency 1 | 16
Tonic - clonic seizures 1 | 44
Wernicke-Korsakoff syndrome 1 | 10
sarcoidosis 1 | 370

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Enzyme 10 | 4,145
Transporter 1 | 473

Reactome Pathway

Lysine catabolism 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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