Development Level

Tbio 15 | 11,651
Tchem 2 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal startle reflex 1 | 15
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 15 | 11,493
ovarian cancer 14 | 8,520
osteosarcoma 13 | 7,950
medulloblastoma, large-cell 11 | 6,241
glioblastoma 10 | 5,792
psoriasis 10 | 6,694
Cancer 9 | 2,499
atypical teratoid / rhabdoid tumor 8 | 5,112
primitive neuroectodermal tumor 8 | 3,035
lung cancer 7 | 4,740
non-small cell lung cancer 7 | 2,890
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
ependymoma 6 | 4,679
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
invasive ductal carcinoma 5 | 2,951
tuberculosis 5 | 2,010
Breast cancer 4 | 3,578
Kidney cancer 4 | 2,613
Neoplasm Invasiveness 4 | 161
Stomach Neoplasms 4 | 300
breast carcinoma 4 | 1,638
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
hepatocellular carcinoma 4 | 547
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung carcinoma 4 | 2,843
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
Breast Neoplasms 3 | 445
Colonic Neoplasms 3 | 142
Colorectal Neoplasms 3 | 243
Endometrial cancer 3 | 311
Kidney disease 3 | 430
Liver Neoplasms, Experimental 3 | 59
Mammary Neoplasms 3 | 425
Neoplasm Metastasis 3 | 168
Ovarian Neoplasms 3 | 102
Pick disease 3 | 1,894
Renal Cell Carcinoma 3 | 214
Schizophrenia 3 | 1,160
Stomach cancer 3 | 30
acute myeloid leukemia 3 | 783
gastric carcinoma 3 | 807
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
ovarian neoplasm 3 | 99
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Abnormality of metabolism/homeostasis 2 | 134
Adenocarcinoma 2 | 122
Adenoma 2 | 167
Alzheimer's disease 2 | 658
Anemia 2 | 365
Bladder Neoplasm 2 | 112
Carcinoma of colon 2 | 32
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Squamous Cell 2 | 110
Disease Progression 2 | 136
Dysgerminoma 2 | 11
ENSP00000256078 2 | 30
Increased hepatocellular carcinoma risk 2 | 27
Increased incidence of hepatocellular carcinoma 2 | 27
Inflammatory bowel disease 2 | 151
Large intestine cancer 2 | 126
Leiomyosarcoma of uterus 2 | 13
Leukemia, Myelocytic, Acute 2 | 120
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Liver disease 2 | 237
Lobular neoplasia 2 | 15
Lung Neoplasms 2 | 232
Mesothelioma, Malignant 2 | 105
Micronodular cirrhosis 2 | 12
Multiple Sclerosis 2 | 540
Multiple myeloma 2 | 1,332
Nerve Degeneration 2 | 121
Osteoporosis 2 | 363
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Pick's disease 2 | 15
Prostatic Neoplasms 2 | 495
Rheumatoid arthritis 2 | 1,191
Somatic mutation 2 | 61
Spinocerebellar ataxia type 2 2 | 23
Squamous cell carcinoma 2 | 129
Transitional cell carcinoma of bladder 2 | 17
Urinary Bladder Neoplasms 2 | 114
Vascular disease 2 | 319
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Cardiovascular System 17 | 15,192
Liver and Pancreas 17 | 16,750

Target Family

Non-IDG 14 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

Reactome Pathway

Listeria monocytogenes entry i... 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Endophilin-A3 SH3GL3 Tbio Non-IDG -1.03962 9.87 97
Epidermal growth factor receptor substrate 15 EPS15 Tbio Non-IDG -2.28374 174.5 164
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Hepatocyte growth factor-regulated tyrosine kinase substrate HGS Tbio Enzyme -2.76643 560.1 379
SH3 domain-containing kinase-binding protein 1 SH3KBP1 Tbio Enzyme -1.80960 71.1 152
Signal transducing adapter molecule 2 STAM2 Tbio Non-IDG -1.25883 21.3 252
Signal transducing adapter molecule 1 STAM Tbio Non-IDG -1.09796 12.9 238