Development Level

Tbio 14 | 10,625
Tchem 4 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to o... 3 | 148
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal pharyngeal arch morph... 1 | 2
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64

Disease

malignant mesothelioma 14 | 3,163
group 3 medulloblastoma 12 | 2,254
medulloblastoma, large-cell 11 | 6,234
non-small cell lung cancer 11 | 2,798
ovarian cancer 11 | 8,492
lung cancer 10 | 4,473
primitive neuroectodermal tumor 10 | 3,031
osteosarcoma 8 | 7,933
psoriasis 8 | 6,685
glioblastoma 7 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
nasopharyngeal carcinoma 6 | 1,056
Breast cancer 5 | 3,099
Waldenstrons macroglobulinemia 5 | 765
colon cancer 5 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
pediatric high grade glioma 5 | 2,712
adrenocortical carcinoma 4 | 1,427
atypical teratoid / rhabdoid tumor 4 | 4,369
atypical teratoid/rhabdoid tumor 4 | 1,095
lung adenocarcinoma 4 | 2,714
Carcinoma 3 | 2,147
Colorectal Neoplasms 3 | 217
Xeroderma pigmentosum 3 | 41
ductal carcinoma in situ 3 | 1,745
oligodendroglioma 3 | 2,849
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Ataxia telangiectasia 2 | 32
Cockayne syndrome 2 | 54
Colonic Neoplasms 2 | 126
Endometriosis 2 | 535
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Seckel syndrome 2 | 35
Werner syndrome 2 | 29
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
chronic lymphocytic leukemia 2 | 244
dermatomyositis 2 | 967
diabetes mellitus 2 | 1,663
ependymoma 2 | 2,514
invasive ductal carcinoma 2 | 2,950
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 789
sonic hedgehog group medulloblastoma 2 | 1,482
Adenocarcinoma 1 | 115
Age related macular degeneration 1 | 84
Alzheimer's disease 1 | 644
Bipolar Disorder 1 | 266
Bladder Neoplasm 1 | 109
Bloom syndrome 1 | 30
Brain Neoplasms 1 | 23
Cancer 1 | 2,346
Cerebrovascular disease 1 | 231
Chloracne 1 | 32
Chronic progressive external ophthalmoplegia 1 | 18
Colorectal Cancer 1 | 62
Deafness 1 | 18
Disease of metabolism 1 | 15
Endometrial Neoplasms 1 | 50
Familial adenomatous polyposis 1 | 33
Fanconi's anemia 1 | 50
Focal glomerulosclerosis 1 | 22
Gaucher disease type 1 1 | 171
Hepatoblastoma 1 | 17
Hypogonadism 1 | 70
IGA Glomerulonephritis 1 | 454
Ischemia 1 | 27
Kidney cancer 1 | 121
Leukodystrophy 1 | 30
Lung Neoplasms 1 | 171
Lynch syndrome 1 | 35
Menopause present (finding) 1 | 20
Mitochondrial myopathy 1 | 24
Neoplasms, Experimental 1 | 33
Neurodegenerative disease 1 | 383
Nijmegen breakage syndrome 1 | 23
Ocular melanoma 1 | 4
Parkinson's disease 1 | 364
Syphilis 1 | 18
Typhoid fever 1 | 22
Vaccinia 1 | 37
Vitelliform macular dystrophy 1 | 14
Williams Syndrome 1 | 10
Williams-Beuren syndrome 1 | 45
acute myeloid leukemia 1 | 785
acute quadriplegic myopathy 1 | 1,157
blepharophimosis, ptosis, and epicanthus inversus syndrome 1 | 8
breast carcinoma 1 | 1,614
glioblastoma multiforme 1 | 347
non-small cell lung carcinoma 1 | 413
subependymal giant cell astrocytoma 1 | 2,287
triple-A syndrome 1 | 18
tuberculosis 1 | 1,563

Tissue

Blood and immune system 20 | 17,995
Cardiovascular System 20 | 17,958
Digestive Tract 20 | 18,473
Endocrine System 20 | 18,512
Female tissues 20 | 18,647
Liver and Pancreas 20 | 18,136
Male tissues 20 | 17,969
Nervous System 20 | 18,561
Respiratory system 20 | 17,484
Skin and soft tissues 20 | 18,115
Urinary Tract 20 | 18,444

Target Family

Enzyme 11 | 4,146
Non-IDG 9 | 11,969

Reactome Pathway

Lagging Strand Synthesis 20 | 20
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.46324 281.9 299
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.94524 8.32 110
Flap endonuclease 1 FEN1 Tchem Enzyme -2.77484 533.8 332
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 16
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.08531 11.5 1277
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.27943 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.04495 11.1 64
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 8.05 121
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76