Development Level

Tbio 11 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

abnormal behavior 2 | 298
abnormal tooth morphology 1 | 24
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
tremors 1 | 39

Disease

glioblastoma 12 | 5,792
adult high grade glioma 11 | 3,801
atypical teratoid / rhabdoid tumor 11 | 5,112
medulloblastoma, large-cell 11 | 6,241
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 9 | 3,081
Carcinoma 9 | 11,493
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
Epilepsy 8 | 792
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
subependymal giant cell astrocytoma 5 | 2,287
Malignant glioma 4 | 26
Schizophrenia 4 | 1,160
pituitary cancer 3 | 1,972
Amyotrophic lateral sclerosis 2 | 451
Autistic Disorder 2 | 364
Autosomal recessive nonsyndromic deafness 98 2 | 4
Bipolar Disorder 2 | 666
Childhood absence epilepsy 2 | 8
Depressive disorder 2 | 409
Encephalitis 2 | 64
Intellectual disability 2 | 1,016
Mental Depression 2 | 333
Type 2 diabetes mellitus 2 | 272
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
interstitial cystitis 2 | 2,312
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
Alzheimer's disease 1 | 658
Amnestic disorder 1 | 35
Anemia 1 | 365
Aphasia 1 | 26
Atopic dermatitis 1 | 952
Auditory auras 1 | 2
Autism Spectrum Disorders 1 | 75
Autism spectrum disorder 1 | 101
Brain Ischemia 1 | 110
Bruxism 1 | 18
Cerebrovascular disease 1 | 238
Choreatic disease 1 | 52
Colitis 1 | 54
Complex partial seizure with impairment of consciousness 1 | 9
Complex partial seizures 1 | 9
Decreased antibody level in blood 1 | 35
Dementia 1 | 175
Diarrhea 1 | 253
EPILEPSY, LATERAL TEMPORAL LOBE, AUTOSOMAL DOMINANT 1 | 3
Epilepsy, Familial Temporal Lobe, 1 1 | 3
Exocrine pancreatic insufficiency 1 | 32
Familial temporal lobe epilepsy 1 1 | 4
Fragile X syndrome 1 | 34
Glioma 1 | 74
Huntington's disease 1 | 76
Hypogammaglobulinemia 1 | 35
Immunologic Deficiency Syndromes 1 | 113
Kidney Failure 1 | 111
Listeriosis 1 | 18
MENTAL RETARDATION, AUTOSOMAL DOMINANT 10 1 | 1
Major Depressive Disorder 1 | 301
Malabsorption 1 | 82
Melanoma 1 | 711
Mood Disorders 1 | 184
Neurodevelopmental Disorders 1 | 70
Nuclear senile cataract 1 | 2
Partial seizures with secondary generalisation 1 | 4
Polycystic ovary syndrome 1 | 360
Pulmonary Fibrosis 1 | 106
Recurrent respiratory infections 1 | 141
Simple Partial Seizures 1 | 2
Skin cancer 1 | 469
Spinocerebellar ataxia type 2 1 | 23
Stiff-Person syndrome 1 | 12
Toxic encephalopathy 1 | 141
Unipolar Depression 1 | 250
Usher syndrome type 3 1 | 5
Williams-Beuren syndrome 1 | 50
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
cystic fibrosis 1 | 1,696
fibroadenoma 1 | 559
juvenile dermatomyositis 1 | 1,187
mucosa-associated lymphoid tissue lymphoma 1 | 484
ovarian cancer 1 | 8,520
pancreatic cancer 1 | 2,398
pancreatic carcinoma 1 | 562
pediatric high grade glioma 1 | 1,064
severe Alzheimer's disease 1 | 47
urothelial carcinoma 1 | 318

Tissue

Endocrine System 13 | 18,159
Nervous System 13 | 16,725
Blood and immune system 12 | 16,909
Digestive Tract 12 | 17,369
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Skin and soft tissues 11 | 17,230
Respiratory system 10 | 16,393
Urinary Tract 10 | 16,678
Cardiovascular System 9 | 15,192

Target Family

Non-IDG 7 | 12,091
Ion Channel 4 | 344
Enzyme 2 | 4,145

Reactome Pathway

LGI-ADAM interactions 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leucine-rich glioma-inactivated protein 1 LGI1 Tbio Non-IDG -2.52790 342.7 207
Leucine-rich repeat LGI family member 4 LGI4 Tbio Non-IDG -0.95884 8.52 114
Leucine-rich repeat LGI family member 3 LGI3 Tbio Non-IDG -0.95263 12.8 119
Voltage-dependent calcium channel gamma-8 subunit CACNG8 Tdark Ion Channel -0.25756 2.01 67
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
Syntaxin-1B STX1B Tbio Non-IDG -1.76579 55.3 27
Disintegrin and metalloproteinase domain-containing protein 23 ADAM23 Tbio Enzyme -1.33824 21.0 193
Disks large homolog 4 DLG4 Tchem Non-IDG -2.98766 883.9 559
Voltage-dependent calcium channel gamma-4 subunit CACNG4 Tbio Ion Channel -0.64900 4.02 117
Leucine-rich repeat LGI family member 2 LGI2 Tbio Non-IDG -0.88890 5.84 94